Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 19 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 19 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Η Μεταανάλυση ως Χρήσιμο Εργαλείο Εκτίμησης στη Φαρμακολογία

Use of Meta-analysis in Pharmacological Research

Συγγραφέας – Author

Στέφανος Μπονόβας1,2, Νικόλαος Μ. Σιταράς1

1Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Πανεπιστήμιο Αθήνας, Αθήνα, Ελλάς
2Τμήμα Επιδημιολογικής Επιτήρησης και Παρέμβασης, Κέντρο Ελέγχου και Πρόληψης Νοσημάτων, Υπουργείο Υγείας και Κοινωνικής Αλληλεγγύης, Αθήνα, Ελλάς

Stefanos Bonovas1,2, Nikolaos M. Sitaras1

1Department of Pharmacology, School of Medicine, University of Athens, M. Asias 75, 11527 Athens, Hellas
2Department of Epidemiological Surveillance and Intervention, Center for Diseases Control and Prevention, Ministry of Health and Social Solidarity, Hellas

Παραπομπή – Citation
Μπονόβας,Σ., Σιταράς,Ν. : Η Μεταανάλυση ως Χρήσιμο Εργαλείο Εκτίμησης στη Φαρμακολογία, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 61-63 (2009)

Bonovas,S., Sitaras,N. : Use of Meta-analysis in Pharmacological Research, Epitheorese Klin. Farmakol. Farmakokinet. 27: 61-63 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Φαρμακολογία, μεταανάλυση, στατίνες, καρκίνος
Pharmacology, meta-analysis, statins, cancer
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. In this review, we present the results of research conducted in the Department of Pharmacology, School of Medicine, University of Athens, using meta-analytic methods in order to evaluate statins for cancer chemoprevention.

Αναφορές – References
1. Hedges L.V., Olkin I.: Statistical methods for meta-analysis. Orlando, FL: Academic Press, 1985

2. Petitti D.: Meta-analysis, decision analysis and cost-effectiveness analysis. New York, NY: Oxford University Press; 1994

3. Dickersin K., Berlin J.A.: Meta-analysis: State-of-the-science. Epidemiol. Rev. 14: 155-176 (1992)

4. L’Abbe K.A., Detsky A.S., O’Rourke K.: Meta-analysis in clinical research. Ann. Intern. Med. 107: 224-233 (1987)

5. Olkin I.: Meta-analysis: reconciling the results of independent studies. Stat. Med. 14: 457-472 (1995)

6. Mantel N., Haenszel W.: Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22: 719-748 (1959)

7. DerSimonian R., Laird N.: Meta-analysis in clinical trials. Control Clin. Trials 7: 177-188 (1986)

8. Thompson S.G., Higgins J.P.: How should meta-regression analyses be undertaken and interpreted? Stat. Med. 21: 1559-1573 (2002)

9. Begg C.B., Mazumdar M.: Operating characteristics of a rank correlation test for publication bias. Biometrics 50: 1088-1101 (1994)

10. Egger M., Davey Smith G., Schneider M., Minder C.: Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634 (1997)

11. Cochran W.G.: The combination of estimates from different experiments. Biometrics 8: 101-129 (1954)

12. Higgins J.P., Thompson S.G.: Quantifying heterogeneity in a meta-analysis. Stat. Med. 21: 1539-1558 (2002)

13. Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G.: Measuring inconsistency in meta-analyses. BMJ 327: 557-560 (2003)

14. Sporn M.: Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res. 36: 2699-2702 (1976)

15. Bonovas S., Tsantes A., Drosos T., Sitaras N.M.: Cancer chemoprevention: a summary of the current evidence. Anticancer Res. 28: 1857-1866 (2008)

16. Bonovas S., Filioussi K., Tsavaris N., Sitaras N.M.: Statins and cancer risk: a literature-based meta-analysis and meta-regression analysis of 35 randomized controlled trials. J. Clin. Oncol. 24: 4808-4817 (2006)

17. Bonovas S., Filioussi K., Flordellis C., Sitaras N.M.: Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million subjects. J. Clin. Oncol. 25: 3462-3468 (2007)

18. Bonovas S., Filioussi K., Tsavaris N., Sitaras N.M.: Use of Statins and breast cancer: a meta-analysis of seven randomized clinical trials and nine observational studies. J. Clin. Oncol. 23: 8606-8612 (2005)

19. Bonovas S., Filioussi K., Tsavaris N., Sitaras N.M.: A call for clinical trials: lipophilic statins may prove effective in treatment and prevention of particular breast cancer subtypes – Reply. J. Clin. Oncol. 24: 2127-2128 (2006)

20. Bonovas S., Filioussi K., Tsavaris N., Sitaras N.M.: Lipophilic statins merit additional study for breast cancer chemoprevention – Reply. J. Clin. Oncol. 24: 2129 (2006)

21. Bonovas S., Filioussi K., Tsavaris N., Sitaras N.M.: Statins and breast cancer prevention: time for randomized controlled trials – Reply. J. Clin. Oncol. 24: 2130-2131 (2006)

22. Bonovas S., Filioussi K., Sitaras N.M.: Statin use and the risk of prostate cancer: a meta-analysis of 6 randomized clinical trials and 13 observational studies. Int. J. Cancer 123: 899-904 (2008)

23. Bonovas S., Filioussi K., Tsantes A., Sitaras N.M.: Use of statins and risk of haematological malignancies: a meta-analysis of six randomized clinical trials and eight observational studies. Br. J. Clin. Pharmacol. 64: 255-262 (2007)

24. Bonovas S., Filioussi K., Sitaras N.M.: Statins are not associated with a reduced risk of pancreatic cancer at the population level, when taken at low doses for managing hypercholesterolemia: evidence from a meta-analysis of 12 studies. Am. J. Gastroenterol. 103: 2646-26451 (2008)

25. Bonovas S., Sitaras N.M.: Statins and pancreatic cancer. Are all statins the same? – Response. Am. J. Gastroenterol. 104: 525 (2009)

26. Bonovas S., Sitaras N.M.: Does pravastatin promote cancer in elderly patients? A meta-analysis. CMAJ 176: 649-654 (2007)

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
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Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

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