Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 20 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 20 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Δυνητικοί Φαρμακολογικοί Στόχοι στη Νόσο του Πάρκινσον: Εστιάζοντας στο Σύστημα Ουβικουιτίνης-πρωτεασώματος

Potential Pharmacological Targets in Parkinson’s Disease: Focusing on Ubiquitin-proteasome System

Συγγραφέας – Author

Μαρία Μυρωνίδου-Τζουβελέκη και Στέργιος Τσαρτσάλης

Α’ Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάδα

Maria Mironidou-Tzouveleki and Stergios Tsartsalis

A’ Laboratory of Pharmacology, Medical School, Aristotle University, Thessaloniki, Hellas

Παραπομπή – Citation
Μυρωνίδου-Τζουβελέκη,Μ., Τσαρτσάλης,Σ. : Δυνητικοί Φαρμακολογικοί Στόχοι στη Νόσο του Πάρκινσον: Εστιάζοντας στο Σύστημα Ουβικουιτίνης-πρωτεασώματος, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 64-67 (2009)

Mironidou-Tzouveleki,M., Tsartsalis,S. : Potential Pharmacological Targets in Parkinson’s Disease: Focusing on Ubiquitin-proteasome System, Epitheorese Klin. Farmakol. Farmakokinet. 27: 64-67 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Νόσος Πάρκινσον, πρωτεάσωμα, ουβικουιτίνη, σύστημα ουβικουιτίνης-πρωτεασώματος
Parkinson’s disease, proteasome, ubiquitin, ubiquitin-proteasome system
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Parkinsons’s disease (PD) is one the most common neurodegenerative conditions in which prominent and severe symptoms including tremor, bradykinesia and even dementia and depression. Death of neurons mainly in substancia nigra pars compacta, formation of eosinophilic inclusions called Lewy bodies and disrution of dopaminergic system are the prominent pathological and pathophysiological features of PD. Interestingly, neuronal malfunction and death are associated with a reduction in proteasomal activity in affected areas. Proteasomes are enzymatic complexes participating in the elimination of misfolded or otherwise useless proteins in cells. Whether this reduction is causative for the other features of the disease, or just a dowstream effect of its progression, remains elusive. However, research in this domain may offer novel therapeutic aproaches for the treatment of PD.

Αναφορές – References
1. Dickson D.: Neuropathology of Parkinsonism. Handbook of Parkinson’s Disease. 3rd Ed., pp. 217-234, Marcel Dekker, Inc., 2003

2. Horowski R., Horowski L., Vogel S., Poewe W., Kielhorm F.-W.: An essay on Wilhelm von Humbolt and the shaking palsy. Neurology 45: 565-568 (1995)

3. Ropper A., Brown R.: Parkinson’s Disease. In: Adam’s and Victor’s Principles of Neurology. 8th Ed., pp. 915-925, McGraw Hill, 2005

4. McAuley J.: The physiological basis of clinical deficits in Parkinson’s disease. Prog. Neurobiol. 69: 27-48 (2003)

5. Guyton A, Hall J.: Basal ganglia-their motor functions. In: Textbook of Medical Physiology. 11th Ed., pp. 707-711, Elsevier Saunders, 2006

6. Galvan A., Wichmann T.: Pathophysiology of Parkinsonism. Clin. Neurophysiol. In Press (2008)

7. Purves D., Augustine G., Fitzpatrick D., Hall W., La Mantia A.-S., McNamara J., Williams S.M.: Modulation of movement by the basal ganglia. In: Neuroscience. 3rd Ed., pp. 417-433, Sinauer Associates Inc, 2004

8. Jung T., Grune T.: The proteasome and its role in the degradation of oxidized proteins. IUBMB Life 60: 743-752 (2008)

9. McNaught K., Olanow W.: Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson’s Disease. Ann. Neurol. 53(Suppl 3): S73-S84 (2003)

10. Konstantinova I.M., Tsimokha A.S., Mittenberg A.G.: Role of proteasomes in cellular regulation. Int. Rev. Cell Mol. Biol. 267: 59-124 (2008)

11. Lim K.-L., Tan J.: Role of the ubiquitin proteasome system in Parkinson’s disease. BMC Biochem. 8(Suppl 1): S13 (2007)

12. Olanow W., McNaught K.: Ubiquitin-proteasome system and Parkinson’s disease. Mov. Disord. 21: 1806-1823 (2006)

13. Belin A., Westerlund M.: Parkinson’s disease: a genetic perspective. FEBS J. 275: 1377-1383 (2008)

14. Schapira A., Cleeter M., Muddle J, Workman J., Cooper M., King R.: Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons. Ann. Neurol. 60: 253-255 (2006)

15. Sun F., Anantharam V., Zhang D., Latchoumycandane C., Kanthasamy A., Kanthasamy A.: Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology 27: 807-815 (2006)

16. Wang X.-F., Li S., Chou A., Bronstein J.: Inhibitory effects of pesticides on proteasome activity: implication in Parkinson’s disease. Neurobiol. Dis. 23: 198-205 (2006)

17. Henn I., Bouman L., Schlehe J., Schlierf A., Schram J., Wegener E., Nakaso K., Culmsee C., Berninger B., Krappmann D., Tatzelt J., Winklholfer K.: Parkin mediates neuroprotection through activation of IκΒ Kinase/Nuclear Factor-κΒ signalling. J. Neurosci. 21: 1868-1878 (2007)

18. Tan E., Puong K., Chan D., Yew K., Fook-Chong S., Shen H., Ng P., Woo J., Yuen Y., Pavanni R., Wong M., Puvan K., Zhao Y.: Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association. Hum. Gen. 118: 484-488 (2005)

19. Gandhi S., Wood N.: Molecular pathogenesis of Parkinson’s disease. Hum. Mol. Gen. 14: 2749-55 (2005)

20. McNaught K., Belizaire R., Isacson O., Jenner P., Olanow W.: Altered proteasomal function in sporadic Parkinson’s disease. Exp. Neurol. 179: 38-46 (2003)

21. Peng Z., Chen M., Yap Y., Manikandan J., Melendez A., Choy M., Moore P., Cheung N.: Proteasome inhibition: an early or late event in nitric oxide-induced cell death? Nitric Oxide 18: 136-145 (2008)

22. Yoshimoto Y., Nakaso K., Nakashima K.: L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells. FEBS Lett. 579: 1197-1202 (2005)

23. Lee J., Wheeler T., Li L., Chin L.-S.: Ubiquitination of α-synuclein by Siah-1 promotes α-synuclein aggregation and apoptotic cell death. Hum. Mol. Gen. 17: 906-917 (2008)

24. Kyratzi E., Pavlaki M., Kontostavlaki D., Rideout H., Stefanis L.: Differential effects of parkin and its mutants on protein aggregation, the ubiquitin-proteasome system, and neuronal cell death in human neuroblastoma cells. J. Neurochem. 102: 1292-1303 (2007)

25. Snyder H., Mensah K., Theisler C., Lee J., Matouschek A., Wolozin B.: Aggregated and monomeric α-synuclein bin to the S6΄ proteasomal protein and inhibit proteasomal function. J. Biol. Chem. 278: 11753-11759 (2003)

26. Pan T., Kondo S., Zhu W., Xie W., Jankovich J., Le W.: Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via aytophagy enhancement. Neurobiol. Dis. 32: 16-25 (2008)

27. Du Y., Li X., Yang D., Zhang X., Chen S., Huang K., Le W.: Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. Exp. Biol. Med. (Maywood) 233: 881-890 (2008)

28. Naoi M., Maruyama W., Yi H., Akao Y., Yamaoka Y., Shamoto-Nagai M.: Neuroprotection by by propargylamines in Parkinson’s disease: intracellularmechanism underlying the anti-apoptotic function and search for clinical markers. J. Neural. Transm. Suppl. 72: 121-131 (2007)

Online ISSN 1011-6575

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Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
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