Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 22 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 22 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Αθανάσιος Χατζησωτηρίου - Athanasios Hatzisotiriou, Αλίκη Ξωχέλλη,Aliki Xohelli, Αναστάσιος Κουρκουτέλης,Anastasios Kourkoutselis, Δωροθέα Καπουκρανίδου - Dorothea Kapoukranidou, Μαρία Αλμπάνη - Maria Albani, Μαρία Κριτσέπη-Κωνσταντίνου,Maria Kritsepi-Constantinou, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek, Στατιστική μελέτη - Statistical study, Τάσος Γερολυμάτος,Tasos Gerolymatos
Τίτλος – Title

Ο μη Συναγωνιστικός ΝΜDA Ανταγωνιστής MK-801 δεν Επηρεάζει τις Αιματολογικές Παραμέτρους σε Επίμυες

Non-competitive NMDA Antagonist MK-801 has no Affect on normal Hematologic Values in Wistar Rats
Συγγραφέας – Author

Αλίκη Ξωχέλλη1, Δωροθέα Καπουκρανίδου1, Μαρία Κριτσέπη-Κωνσταντίνου2, Τάσος Γερολυμάτος1, Αναστάσιος Κουρκουτέλης3, Θανάσης Χατζησωτηρίου1, Μαρία Αλμπάνη1

1Εργαστήριο Φυσιολογίας, Ιατρική Σχολή, 2Διαγνωστικό Εργαστήριο, Κτηνιατρική Σχολή Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς
3Diagnostics Division Thessaloniki, Ελλάς

Aliki Xohelli1, Dorothea Kapoukranidou1, Maria Kritsepi-Constantinou2, Tasos Gerolymatos1, Anastasios Kourkoutselis3, Athanasios Chatzisotiriou1, Maria Albani1

1Dep. Physiology, Medical School, 2Diagnostic Laboratories, Veterinary School, Aristotelian University, Thessaloniki, Hellas, 3Diagnostics Division Thessaloniki, Hellas
Παραπομπή – Citation
 Ξωχέλλη,Α., Καπουκρανίδου,Δ., Κριτσέπη – Κωνσταντίνου,Μ., Γερολυμάτος,Τ., Κουρκουτέλης,Α., Χατζησωτηρίου,Θ., Αλμπάνη,Μ. : Ο μη Συναγωνιστικός ΝΜDA Ανταγωνιστής MK-801 δεν Επηρεάζει τις Αιματολογικές Παραμέτρους σε Επίμυες, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 71-73 (2009)

Xohelli,A., Kapoukranidou,D., Kritsepi-Constantinou,M., Gerolymatos,T., Kourkoutselis,A., Chatzisotiriou,A., Albani,M. : Non-competitive NMDA Antagonist MK-801 has no Affect on normal Hematologic Values in Wistar Rats, Epitheorese Klin. Farmakol. Farmakokinet. 27: 71-73 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords
Γλουταμικό, MK-801, NMDA, αίμα, επίμυες
Glutamate, MK-801, NMDA, blood, rats
Λοιποί Όροι – Other Terms

Στατιστική Μελέτη

Statistical Study
Περίληψη – Summary

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Glutamate is one of the primary endogenous amino acids of the Central Nervous System (CNS). Research over the last years has proven the existence of glutamic acid subunit receptors in additional non-neuronal tissues outside CNS such as the haematopoietic system. The purpose of this paper is to define the possible affect of non-competitive NMDA antagonist MK-801 in routine medical exams such as full blood count and glow cytometry. Materials and methods: MK-801 was administrated intravenously in male wistar rats (250-350 g). Animals treated with MK-801 were compared with a group of controls. The following parameters were evaluated: Full blood count with differential plus CD3, CD54 and CD49a. Results: Initially descriptive statistics (mean and standard deviation). Comparisons were performed by using non-parametric test for two independent samples (Mann-Whitney). Differences were regarded as significant if p<0.01. From the results, one can easily conclude that no difference between the two groups reached the level of significance. Conclusion Further research is needed in order to define the iv affect of glutamate acid‘s and it’s receptors on heamatopoietic system either as a toxic agent or as a therapeutical one.
Αναφορές – References
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12. Ganor Y., Besser M., Ben-Zakay N., Unger T., Levite M.: Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers intergrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J. Immunol. 170: 4362-4372 (2003)

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