| Τίτλος – Title | Τοπικά Αναισθητικά στην Οδοντιατρική
Local anaesthetics in dentistry |
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| Συγγραφέας – Author | Γκυ Μπρις
Guy Briche |
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| Παραπομπή – Citation | Μπρις, Γ.: Τοπικά Αναισθητικά στην Οδοντιατρική, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 1: 28-41 (1983)
Briche, G.: Local anaesthetics in dentistry, Epitheorese Klin. Farmakol. Farmakokinet. 1: 28-41 (1983)
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| Ημερομηνία Δημοσιευσης – Publication Date | Απρίλιος – 1983 – April 1983 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language |
Ελληνικά – Greek | |
| Παραγγελία – Αγορά – Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) – Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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| Λέξεις κλειδιά – Keywords | Οδοντιατρική, τοπική αναισθησία, αντίδραση
Dentistry, local anaesthesia, reaction |
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| Λοιποί Όροι – Other Terms | Άρθρο Article |
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| Περίληψη – Summary | Pain is one of the most commonly symptoms in dentistry. This sensory information travels to brain along nerves by a local flow of sodium ions into, and potassium out, of the axon. Local anaesthetic drugs injected into the tissues can cause a temporary, localised and reversible block to conduction by reducing the permeability of the neural membrane to sodium ions. The practicing dendist should have to choose between a wide variety of local anaesthetics the most convenient one for the particular patient and his needs. But the clinical use of these drugs depends upon Knowledge of their clinical pharmacological and pharmacokinetic properties and the physiological basis of neural blockade. Local anaesthetic drugs are weak bases with pka’s between 7.5 and 8.9. Changes in the pit of infected areas may interfere by changing the ratio of ionised to unionised lipid soluble drug. This fact in correlation to lipid solubility of the drug and the characteristics of the nerve (type and size) can influece the penetration of the drugs into the nerve before conduction is interrupted and local anaesthesia develops. The ester type local anaesthetics are at least partially metabolised by plasma cholinesterase and the amide type agents are extensively metabolised in the liver. But for all type agents the hepatic metabolism is important for their elimination. Other factors — properties to be considered: rapid onset and sufficient duration (equal to the time of intervention), allergies, concentration of the vasoconstrictor (greatly affecting the duration of the anaesthesia) and the absolute and relative toxicity depending of the absolute potency. It should be kept in mind that local anaesthetics are eventually absorbed into the general circulation and can have toxic manifestations. | |
| Αναφορές – References | 1. Hove, G.L, Whitehead, F.I.H.: Local Anaesthesia in Dentistrv. Wright, Bristol, 1972
2. Jacquot, C-, Rapin, J.R., Viellefosse, R.: Pharmacologie dentaire pratique. Julien Prélat, Paris, 1978 3. de Jong, R.H.: Toxic effects of local anesthetics. JAMA. 239:1 166 (1978) 4. Alper, M.H.: Toxicity of local anesthetics. N. Engl. J. Med. 295·. 1432 (1976) 5. Goth, A.: Medical Pharmacology. 9th Ed„ pp. 367-376, The C.V. Mosby Co„ Saint Louis, 1978 6. Strichartz, B.: The chemistry of local anaesthetic agents: Classification of blocking agents. Br. J. Anaesth. 47 (Suppl.):V83 (1975) 7. Mather, L.E., Cousins, M.J.: Local anaesthetics and their current clinical use. Drugs 18′. 185 (1979) 8. Scott, D.B., Jebson, P.J.R., Braid, D.P., Ortengren, B., Frisch, P.: Factors affecting plasma levels of lignocaine and pritocaine. Br. J. Anaesthes. 44:1040 (1972) 9. Routledge, P.A., Stargel, W.W., Kitchell, B.B., Barchowsky, A., Shand, D.G.: Sex related differences in the plasma protein binding of lignocaine and diazepam. Br. J.CUn. Pharmacol. 11:245 (1981) 10. Roberts, D.H., Sonwray, J.H.: Local Analgesia in Dentristy. 2nd Ed, Wright, Bristol, 1979 11. Winter, C.A.: The Physiology and Pharmacology of pain. In «Analgésies» (G. De Stevens, ed). Academic Press Inc., New York, 1965 12. Bonica, J.J.: International Symposium on pain. Advances in Neurology, vol. 4, Raven Press, New York 1974 13. Bonica, J.J., Albefessaid, D.G. (eds): Advances in pain research and therapy. Proceedings of the First World Congress on Pain, Vol. 1, Raven Press, New York, 1976 14. Bonica, J.J., Liebeskind, J.C., Albe—fessaid, D.G. (eds): Advances in pain research and therapy. Proceedings of the Second World Congress on Pain, Vol. 3, Raven Press, New York, 1979 15. Bonica, J.J.: The management of pain. Lea and Febiger, Philadelphia, 1953 16. Gross, E.G., Schriffrin, M.J.: Clinical analgetics. Charles C Thomas Publisher, Springfield, III., 1955 17. Katz, J.: Pain Theory and management. In «Schentific Foundations of Anaesthetics» (Scurr, Feldman eds), p. 266, Heineman, London, 1970 18. Halpern, L.M.: Treating pain with- drugs. Minn.. Med. 57:176 (1974) 19. Ritchie, J.M., Greengard, P.: On the mode of action of local anesthetics. Ann. Rev. Pharmacol. 6:405 (1966) 20. de Jong, R.H.: Physiology and Pharmacology of Local Anaesthesia. Charles C. Thomas, Chicago, 1970 21. Ritchie, J.M.: The mechanism of action of local anaesthetic agents. In «Encyclopedia pharmacoi. Ther.» 6:131 (1971) 22. Πλεσσας, X.T.: Βιοφαρμακευτική. Εκδόσεις Λίτσα, Αθήνα 1978 23. Tucker, G.T., Mather, L.E.: Pharmacokinetics of local anaesthetic agents. Br. J. Anaesthes. 47:213 (1975) 24. Cousins, M.J., Bridenbaugh, P.0. (Eds): Neural Blockade in Clinical Anaesthesia and Pain Management. Lippincott, Philadelphia, 1980 25. Shanes, A.M.: Drugs and nerve conduction. Ann. Ray. Pharmacol. 3:185 (1963) 26. Franz, D.N., Perry, R.S.: Mechanisms for differential block among single myelinated and non—myelinated axons by procaine. J. Physiol. (Lond.) 236:193 (1974) 27. Hodgkin, A.L., Huxley, A.F.: A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117:500 (1952) 28. Bruguerolle, B., Isnardon, R., Zemmour, C., Valli, M., Jadot, G.: Taux plasmatiques de lidocaine en anesthésie dentaire. Thérapie 36:594 (1981) 29. Bruguerolle, B., Isnardon, R.. Valli, M., Jadot, G.: inftuence du sexe sur les taux plasmatiques de lidocalne en anesthésie dentaire. Thérapie 37:593 (1982) 30. Braun, R.D., L1 anesthésie locale dans les affections stomatologîques aiguës. Méd. Hyg. 40:3442 (1982) 31. Various Authors: Proceedings of a symposium on local anaesthesia. Br. J. Anaesthes. 47:163 (1975) 32. Covîno, B.G.: Local anesthesia. New Engl. J. Med. 286:975, 1035 (1972) 33. Luduena, F.P.: Duration of local anesthesia. Ann. Rey. Pharmacol. 9:503 (1969) 34. Boyes, R.N.: A review of the metabolism of amide local anaesthetic agents. Br. J. Anaesthes. 47:225 (1975) 35. Moore, D.C., Bridenbaugh, L.D., Thompson, G.E., Balfour, R.I., Horton, W.C.: Factors determining dosages of amide—type local anaesthetic drug. Anesthesiology 47:263 (1977) 36. Artusio, J.F.: Anesthetics. In «Drugs of Choise 1980-1981» (W. Modell, ed), pp. 238-256, The C.V. Mosby CO., St. Louis, 1 980 37. Adrîani, J.: The pharmacology of anesthetic drugs. 5th Ed. pp. 131-145, Charles C. Thomas Publisher, Springfield, Illinois, 1973 |
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1983 – ANNUAL SUBSCRIPTION 1983 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language |
Ελληνικά – Greek |
| Παραγγελία – Αγορά – Order – Buy |
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