Τόμος 1 (1983) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 1– Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title Υποδοχείς Στεροειδών Ορμονών: Μόρια-κλειδιά για τη Βιοχημεία και Φαρμακολογία των Ορμονικών Στεροειδών

Steroid Hormone Receptors: Macromolecules indued with a key-role in the Biochemistry and Pharmacology of steroid
Hormones

Συγγραφέας – Author Μιχάλης Ν. Αλέξης και Κώστας Ε. Σεκερης

Κέντρο Βιολογικών Ερευνών, Εθνικό Ίδρυμα Ερευνών, Διευθυντής Καθηγ. Κ.Ε. Σέκερης

Μ. N. Alexis and C. Sekeris

Biological Research Center; National Hellenic Research Foundation 48, Vas. Constantinou Ave. Athens, Greece

Παραπομπή – Citation Αλέξης, Μ.Ν. και Σέκερης, Κ.Ε.: Υποδοχείς Στεροειδών Ορμονών: Μόρια-κλειδιά για τη Βιοχημεία και Φαρμακολογία των Ορμονικών Στεροειδών, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 1: 5-14 (1983)

Alexis, M.N. and Sekeris, C. : Steroid Hormone Receptors: Macromolecules indued with a key-role in the Biochemistry and Pharmacology of steroid

Hormones, Epitheorese Klin. Farmakol. Farmakokinet. 1: 5-14 (1983)

Ημερομηνία Δημοσιευσης – Publication Date Απρίλιος – 1983 – April 1983
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Full Text Language
Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords Στεροειδείς ορμόνες,  μόρια-κλειδιά, βιολογία

 

Steroid Hormones, molecular, biology

Λοιποί Όροι – Other Terms Άρθρο
Article
Περίληψη – Summary The mechanism of steroid hormone action is central to Molecular Biology and Pharmacology, since steroids are active in the therapy of a number of clinical cases from simple infections to cancer. Steroid hormones are involved in the regulation of gene expression and metabolic state of the eucaryotic cell. Most of their effects are excerted through specific protein receptor molecules. Steroid hormone—receptor mechanisms underlying the physiology and pathology of cells and known target tissues, e.g. the uterus and the control of menstrual cycle, breast cancer and antiestrogen resistance, leukemias and glucocorticoid resistance, brain and neural behavioral plasticity are examined in detail. A consensus on future trends of steroid receptor research is finally presented, relating to the use of antibodies to receptor proteins and receptor regulated proteins in cancer therapy prognosis.
Αναφορές – References 1.         Karlson, P., Sekeris, C.E.: Biochemical mechanism of hormone action. Acta Endocrin. 53: 505 (1966).

2.         Jensen, E.V. et al.: A two-step mechanism for the interaction of estradiol with rat uterus. Proc. Nat. Acad. Sci. 59: 632 (1968).

3.         Voigt, J. et al.: Influence of the adrenal gland on uptake, retention, metabolism and binding to cytoplasmic proteins of l3H) cortisol by the rat liver. Hoppe-Seylers Z. Physiol. Chem. 363: 159 (1982).

4.         Munck, A„ Foley, R.: Activated and non-activated qlucocorticoid receptor complexes in rat thymus cells: Kinetics of formation and relation to steroid structure. J. Steroid Biochem. 12: 225 (1980).

5.         Smith, R.D., Dana, R.C.: Characteristics of dexamethasone binding to Hippocampal cytosol receptors. J. Steroid Biochem. 10: 147 (1979).

6.         Stumpf, W.E., Sar, M.: The differential distribution of estrogen, progetin, androgen and qlucocorticoid. J. Steroid Biochem. 7: 1170 (1979).

7.         M.N Alexis et al.: Glucocorticoid receptors in rat brain and pituitary. In Cell Function and Differentiation (Evangelopoulos Ed.) (Part A) pp. 207-217, ALAN R. LISS, INC, N.Y. 10011, USA (1983).

8.         Horwitz, K.B., Horwitz, LD,: Canine vascular tissues are targets for androgens, estrogens, progestins and qlucocorticoids. J. Clinical invest. 69: 750 (1982).

9.         Homo, F. et al.: Glucocorticoid receptors and their functions in lymphocytes. J. Steroid Biochem. 12: 433 (1980).

10.       Claire, M. et al.: Effects of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney. J. Biol. Chem. 256: 142 (1981).

11.        Moguilewsky, M„ Raynaud, J. P.: Evidence for a specific mineralocorticoid receptor in rat pituitary and brain. J. Steroid Biochem. 12: 309 (1980).

12.       Traish, A.N. et al.: A new procedure for the quantitation of nuclear and cytoplasmic androgen receptors. J. Bioi.Chem. 256, 12028 (1981).

13.       A ardi, B., Ohno S.: Physical properties of androgen receptors in brain cytosol from normal and testicular feminized mice. Endocrinology 103: 760 (1978).

14.       Pajune, A.E.I. et al.: Androgenic requlation of ornithine decarboxylase activity in mouse kidney and its relationship to changes in cytosol and nuclear androgen receptor concentrations. J. Biol. Chem. 257 8190 (1982).

15.       Tsai, Y.H. et al.: Effect of sodium molybdate on the binding of androgen receptor complexes to germ cell and Sertoli cell chromatin. J. Steroid Biochem. 17: 131(1982).

16.       Chang, C. H. et al.: Purification and characterization of androgen receptor ftom steer seminal vesicle. Biochemistry 21: 4102 (1982).

17.       King, R. J. B. et al.: Intracellular Estradiol, Estrone and Estrogen receptor levels in Endometria from postmenopausal women receiving estrogens and progestins. J. Steroid Biochem. 13: 377 (1980).

18.       King, R. J. B. et al.: Regulation of estrogen and progesterone receptor levels in epithelium and stroma from preand postmenopausal endometria. J. Steroid Biochem. 16: 21 (1982).

19.       Leibl, H., Spona, J.: Differential stimulation by 178- Estradiol and synthetic estrogens of progesterone — receptor and of translocation of estrogen receptor in rat pituitary and uterus. Endocrinology 110: 265 (1982).

20.      Eldied, M.R., Andersen, R. N.: The effect of leupeptin on Progestin Receptors of Human Uterine Tissues. J. Clin.Endocrin. Metab. 55: 1007 (1982).

21.       Ogle, T.F., Beyer, B.K.: Steroid — Binding specificity of the progesterone receptor from rat placenta. J. Steroid Biochem. 16: 147 (1982).

22.       Braunsberg, H., Hammand, K.D.: Methods of Steroid Receptor Calculation: An Interlaboratory study. J. Steroid Biochem. 11: 1561 (1979).

23.       Papamichail, M. et al.: Immunocytochemical demonstration of  qlucocorticoid receptors in different cell types and their translocation from the cytoplasm to the cell nucleus in the presence of dexamethasone. Exper, Cell Research 125: 490 (1980).

24.       Jensen, E.J. et al.: Receptors Reconsidered: A 20 — Year Perspective. In Recent Progress in Hormone Research. 38, p. 1, Academic Press, N.Y., USA, (1982).

25.       Kisling, S. et al.: The existence of specific receptors for glucocorticoids on the plasma membrane of the rat liver. Biokhimiya {English Edition) 44: 1600 (1979).

26.       Nenci, I. et al.: Cytochemical Evidence for steroid Bindings Sites in the Plasma Membrane of Target Cells. In Perpectives in Steroid Receptor Research p. 61, Raven Press, N.Y. U.S.A., 1980.

27.       Muldoon, T.G.: Molecular and Functional Anomalies in the Mechanism of the Estrogenic Action of 4-Mercuri-176-Estradiol. J. Biol. Chem. 255: 1358 (1980).

28.      Gehring, U. et al.: Different states of Glucocorticoid Receptors in intact cells and cytosol preparations. Biochem. Biophys. Res. Commun. 108:627 (1982).

29.       Payvar, F. et al.: Purified glucocorticoid bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoid in vivo. Proc. Nat. Acad. Sci 78: 6628 (1981).

30.      Taylor, R.N., Smith, R.G.: Effects of highly purified Estrogen Receptors on Gene Transcription in Isolated Nuclei. Biochemistry 21: 1781 (1982).

31.       Alexis, M.N. et ai.: Activation and changes in the sedimentation properties of rat liver glucocorticoid receptor. J. Steroid Bloc hem. (1983), un6 exTUmvcrri.

32.       Ohl, V. S. et al.: Receptor properties of Corticosteroid Binder IB. Archives Biochem. Biophys. 217: 162 (1982).

33.       Marco’vie’, R.D., Litwack, G.: Activation of Liver and Kidney Glucocorticoid — Receptor complexes occurs in vivo. Archives Biochem. Biophys. 202: 374 (1980).

34.       Isohashi F. et al.: A low — molecular — weight translocation modulator and its interaction with a macromolecular translocation inhibitor of the activated receptor-glucocorticoid complex. J. Biochem. (Tokyo) 88: 775 (1980).

35.       Kanazir, D., et al.: The structure and regulatory function (s) of Cortisol Receptor — 1: Extragenomic effects dependent on the Cortisol Receptor activation. J. Steroid Biochem. 11: 389 (1979).

36.       Cake, M.H., Litwack, G.: Effect of Methylxanthines on binding of the glucocorticoid receptor to DNA — cellulose and nuclei. Eur. J, Biochem. 82: 97 (1978).

37.       Mednieks, M.l. et al.: Cyclic adenosine 3′: 5 — monophosphate dependent protein phosphorylation and the control of Leukemia L1210 cell growth. Cancer Research 42: 2742 (1982).

38.      Bloom, E. et al.: Nuclear binding of glucocorticoid receptors: Relation between cytosol binding, activation and the biological response. J. Steroid Biochem. 12: 175 (1980).

39.       Eckert, R.L., Katzenellenbogen, B.S.: Effects of estrogens and antiestrogens on estrogen receptor dymanics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Research 42: 139 (1982).

40.      Fliggins, S.J., Gehring, U.: Molecular mechanisms of steroid hormone action. Advances in Cancer Research 28: 313 (1978).

41.       McEwen, 8.S. et al.: Steroid Hormones: Humoral signals which alter brain cell properties and functions. In Recent Progress in Hormone Research 38, p. 41, Academic Press, N.Y. USA, 1982.

42.       Simons, S.S. et al.: Interactions of glucocorticoid receptor — steroid complexes with acceptor sites. J. Biol. Chem. 251: 334 (1976).

43.       Senior, M.B., Frankel, F.R.: Evidence for two kinds of chromatin binding sites for the Estradiol — receptor complex. Celt 14: 857 (1978).

44.       Buller, R.E. et al.: Progesterone — binding components of Chick Oviduct. IX The kinetics of Nuclear Binding. J. Biol. Chem. 250: 809 (1975).

45.       Cidlowski, J.A., Munck, A.: Multiple forms of nuclear binding of glucocorticoid receptor complexes in rat thymocytes. J. Steroid Biochem 13: 105 (1980).

46.       Yammamoto, K.R., Alberts, B.: The interaction of estradiol receptor protein with the genome: an argument for the existence of undetected specific sites. Cell 4: 301 (1975).

47.       Sekeris, C.E.: Steroid hormone-receptor interactions and possible molecular effects. Biological characterization of Human Tumors, p. 306, Excerpta Medtca, Amsterdam, 1979.

48.      Hansen, E.R., Brooks, S.C.: Estrogen receptor formation during the processing of estradiol — receptor complex in MCF — 7 cells. Cancer research 42: 1967 (1982).

49.       Edwards, D.P. et al.: Estrogen and progesterone receptor proteins in breast cancer, Biochim. Biophys. Acta 560: 457 (1979).

50.       Erans, E. et al.: Estrogen receptor — DNA interaction. Difference between activation by estrogen and antiestrogen. Eur. J. Biochem. 128: 185(1982).

51.       Sibley, C.H., Tomkins, G.M.: Isolation of lymphoma cell variants resistant to killing by glucocorticoids. Cell2:213 (1974).

52.       Tomkins, T. et al.: Control of specitic gene expression in higher organisms. Science 166: 1474 (1969).

53.       Cidlowski, J.A., Cidlowski, N.B.: Glucocorticoid receptors and the cell cycle. Evidence that the accumulation of glucocorticoid receptors during the S phase of the cell cycle is dependent on ribonucleic acid and protein synthesis. Endocrinology HO: 1653 (1982).

54.       Schmidt, T.J. et al.: Correlation between the activities of DNA polymerase a and the glucocorticoid receptor. Proc. Nat. Acad. Set 79: 4555 (1982).

55.       Stevens, J. et al.: Immunochemical differences between glucocorticoid receptors from corticoid — sensitive and resistant malignant lymphocytes. Cancer Research 41: 134 (1981).

56.       Boyd-Leinen, P.A. et al.: Nonfunctioning progesterone receptors in the developed oviducts from estrogen — withdrawn immature chicks and in aged nonlaying hens. Endocrinology 111: 30 (1982).

57.       Brown, T.R. et al.: Human complete androgen insensitivity with normal dihydrotestosterone receptor binding capacity in cultured genital skin fibroblasts. Evidence for a qualitative abnormality of the receptor J. C/in. Endocrinol. Metab. 55:61 (1982)

58.       Kernel’, L. et al.: Studies on high affinity binding of mineralo — and glucocorticoids in rabbit aorta cytosol. J. Steroid Biochem. 16:245 (1982)

59.       Eckert, R.L., Katzenellenbogen, B.S.: Human endometrial cells in primary tissue culture: Modulation of the progesterone receptor level by natural and synthetic estrogens in vivo. J. CUn. Endocrinol Metab. 52:699 (1981)

60.      Clarke, C.L. et al.: Induction of estrogen sulfotransferase in the human endometrium by progesterone in organ culture. J. CUn. Endocrin. Metab. 55:70 (1982)

61.       Bayard, F. et al.: Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium. J, Clin. Endocrin. Metab. 46:635 (1978)

62.       Tsibris, J.C.M. et al.: The uneven distribution of estrogen and progesterone receptors in human endometrium. Steroid Biochem. 74:997 (1981)

63.       Edwards, D.P. et al.: Subcelluiar compartmentalization of estrogen receptors in human breast cancer cells. Exper. Cet! Research 727:197 (1980)

64.       Galili, U. et al.: Metabolic and ultrastructural aspects of the in vivo lysis of chronic lymphocytic leucemia cells by glucocorticoids. Cancer Research 42:1433 (1982)

65.       Bloomfield, C.D. et al.: In vitro glucocorticoid studies in human lymphoma: clinical and biologic significance. J. Steroid Biochem. 75:275 (1981)

66.       Nanni, P. et al.: Glucocorticoid receptor an in vitro sensitivity to steroid hostrones in human lymphoproliferative diseases and myeloid leukemia. Cancer 49:623 (1982)

67.       Costlow, M.E. et al.: Glucocorticoid receptors in childhood acute lymphocytic Leukemia. Cancer Research 42:4801 (1982)

68.      Smith, R.G.: Quality control in steroid hormone receptor assay. Cancer 46:2946 (1980)

69.       Hoogstraten, B. et al.: Tamoxiten and oophorectomy in the treatment of recurrent breast cancer. A southwest oncology group study. Cancer Research 42:4788 (1982)

70.       Pegoraro, RJ. et al.: Cytoplasmic and nuclear estrogen and progesterone receptors in male breast cancer. Cancer Research 42:4812 (1982)

71.       DeWys et al.: A proposed model for the prediction of responce to endocrine therapy in breast cancer from the estrogen receptor status on one site and the number of metastatic sites. Cancer Research 40:2423 (1980)

72.       Friedman, H.M., Gläubiger, D.L.: Assessment of in vitro drug sensitivity of human tumor cells using pH] thymidine incorporation in a modified human tumor stem cell assay. Cancer Research 42:4683 (1982)

73.       Ciocca, D.R. et al.: Immunohistochemical detection of an estrogen — regulated protein by monoclonal antibodies. Cancer Research 42:4256 (1982)

74.       Capony, F. et al.: Antibodies to the estrogen induced 52K protein released by human breast cancer cells. Biochem. Biophys. Res. Comm. 108:8 (1982)

75.       McEwen, B.S. et al.: Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macr’omolecules from rat brain regions and pituiraty. Brain Research 705:129 (1976)

76.       Jones, M.T. et al.: Dynamics and mechanics of costicosteroid feedback at the hypothalamus and anterior pituitary gland. J. Endocrinology 73:405 11977)

77.       Phillips, M., Tachjion, A.H.: Characterization of an early inhibitory effect of glucocorticoids on stimulated adrenocorticotropin and endorphin release from a clonal strain of mouse pituitary cells. Endocrinology 7 70:892 (1982)

78.       McLennan, I.S. et al.: Glucocorticoids modulate transmitter choice in developing superior cervical ganglion. Nature 283:206 (1980)

79.       Parsons et al.: The temporal relationship between estrogeninducible progestin receptors in the female rat brain and the time course of estrogen activation of mating behavior. Endocrinology 707:774 (1980)

80.      McGinnis, J.F., DeVellis, J.: Glucocorticoid regulation in rat brain cell cultures: Hydrocortisone increases the rate of synthesis of glucerol phosphate dehydrogenase in C6 glioma cells. J. Biol. Chem. 253:8483 (1978)

81.       Nestler, E.J. et al.: Corticosterone increases the amount of protein 1, a neuron — specific phosphoprotein in rat Hippocampus. Science 272:1162 (1981)

82.      Jonakait, G.M. et al: Maternal glucocorticoid hormones influence neurotransmitter phenotypic expression in embryos. Science 270:551 (1980)

83.      McEwen, B.S. et al.: Aromatization: important for sexual differentiation ot the neonatal rat brain. Horm. Behav. 9:249 (1977)

84.      Reddy, V.V. et al.: Conversion of androstenedione to estrone by neural tissues from fetal and neonatal rats. Endocrinology 94:117(1974)

85.       Morali, G. et al: Inhibition of testosterone — induced sexual behavior in the casrated male rat by aromatase blockers. Horm. Behav. 9:203 (1977)

86.      Tsawdaroglou, N. et al.: Dexamethasone binding proteins in cytosol and nucleus of rat thymocytes. Purification of three receptor proteins. Eur. J. Biochem. 174:305 (1981)

87.       Papamichail, M. et al.: The detection of glucocorticoid receptors in Breast cancer by immunocytochemical and biochemical methods. Int. J. Cancer 29:147 (1982)

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