Τίτλος – Title | Κυτταροστατικά: Αλκυλιωτικές Ουσίες
Cytostatics: Alkylating Agents |
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Συγγραφέας – Author | Αθανάσιος Δ. Παπαγεωργίου
Συμεωνίδειο Ερευνητικό Κέντρο, Θεαγένειο Ιατρικό Ινστιτούτο Θεσσαλονίκης Athanassios D. Papageorgiou Theagenion Medical Institut, Thessaloniki |
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Παραπομπή – Citation | Παπαγεωργίου, Α.: Κυτταροστατικά: Αλκυλιωτικές Ουσίες, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 2(1): 53-66 (1984)
Papageorgiou, A.: Cytostatics: Alkylating Agents, Epitheorese Klin. Farmakol. Farmakokinet. 2(1): 53-66 (1984) |
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Ημερομηνία Δημοσιευσης – Publication Date | Απρίλιος 1984 – April 1984 | |
Γλώσσα Πλήρους Κειμένου – Full Text Language |
Ελληνικά – Greek | |
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Λέξεις κλειδιά – Keywords | Αλκυλιωτικές ουσίες
Alkylating Agents |
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Λοιποί Όροι – Other Terms | Άρθρο Article |
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Περίληψη – Summary | The literature on alkylating agents is very extensive, partly because of their wide range of clinical applications and partly because of their basic scientific interest. Several review articles are available that are included in the reference section. The purpose of this review is: to outline our knowledge of the alkylating agents, and to present certain areas of active research in greater detail. It is tempting to try to pull the maximum number of these observations together in some theoretical framework, and we have done this here by focusing on: 1. The classification of alkylating agents; 2. The mechanism of action. Alkylating agents have been shown to react with a wide range of cellular components (nucleophylic sites). Thus, cellular proteins and nucleic acids are alkylated as well as most of the low-molecular wheight compounds. DNA is the primary target of the alkylation and some details of these interactions are described here; 3. The distribution and cellular uptake of alkylating agents; and 4. Their clinical applications. | |
Αναφορές – References | 1. Gilman, A., Philips, F.S.: The biological actions and therapeutic applications of the b-chloroethylamines and sulfides. Science 103: 409 (1946)
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