Τόμος 25 (2007) – Τεύχος 1 – Άρθρο 17 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 25 (2007) – Issue 1– Article 17 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Α. Ζάρρος,A. Zarros, Άρθρο - Article, Β. Στολάκης,V. Stolakis, Διονύσιος Β. Κόκκινος - Dionisios V. Kokkinos, Διονύσιος Κόκκινος,Dennis V. Cokkinos, Ιορδάνης Μουρούζης,Iordanis Mourouzis, Κωνσταντίνος Πάντος,Constantinos Pantos, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek, Σ. Τσακίρης,S. Tsakiris, Χ. Καραγεωργίου,H. Carageorgiou
Τίτλος – Title

Επίδραση του Πειραματικού Υπερ- και Υπο-θυρεοειδισμού επί της Δραστικότητος της Ακετυλχολινεστεράσης, της (Na+,K+)- και της Mg2+-ATPάσης Εγκεφαλικών Δομών Ενηλίκων Επιμύων

Effect of Experimental Hyper- and Hypothyroidism on Acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase Activities of Adult Rat Brain Regions
Συγγραφέας – Author

Χ. Καραγεωργίου1, Κ. Πάντος1, Α. Ζάρρος1,2, Β. Στολάκης3, Ι. Μουρούζης1, Δ. Κόκκινος4 και Σ. Τσακίρης2

1Εργαστήριο Πειραματικής Φαρμακολογίας και 2Εργαστήριο Πειραματικής Φυσιολογίας, Ιατρική Σχολή Πανεπιστημίου Αθηνών, Αθήνα, Ελλάς, 3Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών, Πανεπιστήμιο Ιωαννίνων, Ιωάννινα, Ελλάς, Ελλάς, 4Ωνάσειο Καρδιοχειρουργικό Κέντρο, Α΄ Καρδιολογική Κλινική, Αθήνα, Ελλάς

H. Carageorgiou1, C. Pantos1, A. Zarros1,2, V. Stolakis3, I. Mourouzis1, D. Cokkinos4 and S. Tsakiris2

1Department of Experimental Pharmacology, and 2Department of Experimental Physiology, Medi­cal School, University of Athens, Athens, Greece, 3Department of Biological Applications and Technology, Science and Technology School, University of Ioannina, Ioannina, Greece, 4Onassis Cardiac Surgery Center, First Cardiology Department, Athens, Greece
Παραπομπή – Citation
Καραγεωργίου,Χ.,  Πάντος,Κ., Ζάρρος,Α.,  Στολάκης,Β., Μουρούζης,Ι., Κόκκινος,Δ., Τσακίρης,Σ.  : Επίδραση του Πειραματικού Υπερ- και Υπο-θυρεοειδισμού επί της Δραστικότητος της Ακετυλχολινεστεράσης, της (Na+,K+)- και της Mg2+-ATPάσης Εγκεφαλικών Δομών Ενηλίκων Επιμύων, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 25: 52-54 (2007)
Carageorgiou,H., Pantos,C., Zarros,A., Stolakis,V., Mourouzis,I., Cokkinos,D., Tsakiris,S. : Effect of Experimental Hyper- and Hypothyroidism on Acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase Activities of Adult Rat Brain Regions, Epitheorese Klin. Farmakol. Farmakokinet. 25: 52-54 (2007)
Ημερομηνία Δημοσιευσης – Publication Date
2007 – 2007
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords
–
AChE, (Na+,K+)-ATPase, Mg2+-ATPase, rat, brain, hyperthyroidism, hypothy­roidism
Λοιποί Όροι – Other Terms

Άρθρο

Article
Περίληψη – Summary
–

The aim of this work was to investigate how the metabolic reactions could affect the activities of acetylcholinesterase (AChE), (Na+,K+)-ATPase and Mg2+-ATPase in the brain regions (frontal cortex, hippo­campus, hypothalamus and cerebellum) of hyper- and hypothyroid adult male rats. Hyperthyroidism was induced in rats by subcutaneous administration of thyroxine (25μg/100g body weight) once daily for 14 days, while hypothyroidism was induced by oral admini­stration of propylthiouracil (0.05%) for 21 days. The enzyme activities were evaluated spectrophotometri­cally in the homogenated brain re­gions of 10 three-animal pools. In hyperthyroidism, AChE activity was found significantly increased in the hippocampus (+22%), decreased in the cerebellum (-23%) and re­mained unchanged in the frontal cortex and the hypo­thalamus. (Na+,K+)-ATPase was signifi­cantly inhibited in the hyperthyroid rat hippocampus (-47%) and cerebel­lum (-26%), with no significant changes in the hypothalamus and the frontal cortex. In hypothyroid­ism, AChE activity was found significantly increased in the hippocampus (+21%), decreased in the frontal cortex (-23%) and cerebellum (-17%), while it re­mained unchanged in the hypothalamus. (Na+,K+)-ATPase was significantly inhibited in the hypothyroid rat frontal cortex (-35%), hippocampus (-43%) and cerebellum (-27%), while no significant changes were recorded in the hypothalamus. Mg2+-ATPase was found unaltered in all regions of both hyper- and hypothy­roid rat brains. Our data revealed that thyroid hormones affect the examined adult rat brain parame­ters, in a region- and state-specific way. Frontal cortex was affected only by hypothyroidism, while hippocam­pal and cerebellar enzymes were affected in a similar way by hyper- and hypothyroidism. The examined rat hypothalamic enzymes do not seem to be affected (at least under the experimental procedures followed).
Αναφορές – References
 1. Pantos C.I., Cokkinos D.D., Tzeis S.M., Malliopoulou V., Mourouzis I.S., Carageorgiou H.C., Limas C., Varonos D., Cokkinos D.V.: Hyperthyroidism is associated with pre­served preconditioning capacity but intensified and acceler­ated ischemic contracture in rat heart. Basic Res. Cardiol. 94: 254-260 (1999)

2. Pantos C., Malliopoulou V., Mourouzis I., Sfakianoudis K., Tzeis S., Doumba P., Xinaris C., Cokkinos A.D., Cara­georgiou H., Varonos D.D., Cokkinos D.V.: Propyl­thiouracil-induced hypothyroidism is associated with in­creased tolerance of the isolated rat heart to ischaemia-reperfusion. J. Endocrinol. 178: 427-435 (2003)

3. Carageorgiou H., Tzotzes V., Pantos C., Mourouzis C., Zarros A., Tsakiris S.: In vivo and in vitro effects of cad­mium on adult rat brain total antioxidant status, acetylcholi­nesterase, (Na+,K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine. Basic Clin. Pharmacol. Toxicol. 94: 112-118 (2004)

4. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275 (1951)

5. Ellman G.L., Courtney K.D., Andres V.Jr., Featherstone R.M.: A new and rapid colorimetric determination of acetylcho­linesterase activity. Biochem. Pharmacol. 7: 88-95 (1961)

6. Bowler K., Tirri R.: The temperature characteristics of synaptic membrane ATPases from immature and adult rat brain. J. Neurochem. 23: 611-613 (1974)

7. Carageorgiou H., Pantos C., Zarros A., Mourouzis I., Varonos D., Cokkinos D., Tsakiris S.: Changes in antioxi­dant status, protein concentration, acetylcholinesterase, (Na+,K+)-, and Mg2+-ATPase activities in the brain of hy­per- and hypothyroid adult rats. Metab. Brain Dis. 20: 129-139 (2005)

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