Τόμος 34 (2016) – Τεύχος 2 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 34 (2016) – Issue 2 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title
Νεότερα Δεδομένα στη Φαρμακευτική Αντιμετώπιση της Παχυσαρκίας

New Aspects in the Pharmaceutical Treatment of Obesity

Συγγραφέας – Author

Παναγιώτα Καράτση1, Ελένη Κίντζιου2

1Αισθητικός Κοσμητολόγος MSc, 2Φαρμακοποιός, Καθηγήτρια Τμήματος Αισθητικής και Κοσμητολογίας, Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, ΤΕΙ Αθήνας, Αγ. Σπυρίδωνος, GR-12243, Αιγάλεω, Ελλάς

Panagiota Karatsi1, Eleni Kintziou2

1Aesthetician Cosmetologist MSc, 2Pharmacist, Professor of Aesthetics and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Egaleo, Athens, Hellas

Παραπομπή – Citation
Καράτση,Π., Κίντζιου,Ε.  : Νεότερα Δεδομένα στη Φαρμακευτική Αντιμετώπιση της Παχυσαρκίας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 34: 75-83 (2016)
Karatsi,P., Kintziou,E. : New Aspects in the Pharmaceutical Treatment of Obesity, Epitheorese Klin. Farmakol. Farmakokinet. 34: 75-83 (2016)
Ημερομηνία Δημοσιευσης – Publication Date
18 Ιανουαρίου 2016 – 2016-01-18
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Λέξεις κλειδιά – Keywords
Παχυσαρκία, Θεραπεία, φαρμακευτικές ουσίες
Λοιποί Όροι – Other Terms

Στατιστική Μελέτη

Statistical Study

Περίληψη – Summary
Η παχυσαρκία αποτελεί μια σύγχρονη μάστιγα που τείνει να πάρει διαστάσεις παγκόσμιας επιδημίας. Aυτή αποτελεί ένα πολύ σύνθετο πρόβλημα, καθώς είναι το αποτέλεσμα ψυχολογικών, περιβαλλοντικών, γενετικών και συμπεριφορικών παραγόντων. Εκτός από τις κακές διατροφικές συνήθειες, την έλλειψη σωματικής δραστηριότητας, άλλοι παράγοντες που συνευθύνονται για την εμφάνιση της παχυσαρκίας είναι γενετικοί (γονίδια), μεταβολικοί, ενδοκρινολογικοί, οικογε-νειακοί, κοινωνικοί και ψυχολογικοί. Ως κύρια αιτία πρόκλησης της παχυσαρκίας θεωρείται η αύξηση της ενεργειακής πρόσληψης σε σχέση με την ενεργειακή κατάνάλωση. Η απώλεια βάρους και η σωματική άσκηση εξακολουθούν να αποτελούν τα σημαντικότερα όπλα ενάντια στην παχυσαρκία. Ωστόσο, όταν η δίαιτα και η αύξηση της φυσικής δραστηριότητας δεν έχουν τα επιθυμητά αποτελέσματα, η χορήγηση φαρμακευτικής αγωγής αποτελεί τα επόμενο βήμα για την αντιμετώπιση της παχυσαρκίας. Σήμερα, έχουν πλέον αναπτυχθεί αρκετές νέες ουσίες για να καταπολεμήσουν την παχυσαρκία. Μερικές από αυτές είναι η λορκασερίνη, ο συνδυασμός φεντερμίνης/τοπιραμάτης, ο συνδυασμός βουπροπριόνης/ναλτρεξόνης κ.α. Σκοπός της παρούσας εργασίας είναι η βραχεία ανασκόπηση της βιβλιογραφίας σχετικά με τα νεότερα δεδομένα για τη φαρμα-κευτική αντιμετώπιση της παχυσαρκίας.
Obesity is a modern scourge that tends to become a global blast. It is a very complex problem as it is the result of psychological, environmental, genetic and behavioral factors. In addition to poor nutrition habits, the lack of physical activity, there are some other factors that are responsible for obesity, such as genetic (genes), metabolic, endocrine, family, social and psychological factors. The main cause of obesity is considered to be the increase of energy intake in relation to the energy consumption. Weight loss and exercise still remains the most important weapons against obesity. If diet and exercise don’t have the desired result, medication is the next step in the treatment of obesity. They have been developed nowadays several new substances in order to confront obesity. Some of these are lorcaserin, the combination of phentermine and topiramate, the combination of bupropion and naltrexone etc. The main purpose of this study is a short review of the literature that deals with the newest data in treating obesity using medications.
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