Τόμος 20 (2002) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 20 (2002) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Ρευματοειδής Αρθρίτις: Παθογένεια και Νέες Θεραπευτικές Προσεγγίσεις

Rheumatoid Arthritis: Patho­genesis and New Therapeutic Ap­proaches

Συγγραφέας – Author

Φραγκίσκη Ανθούλη-Αναγνωστοπούλου

Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, Τεχνολογικό Εκπαιδευτικό Ίδρυμα (ΤΕΙ), Αθήνα, Ελλάς

F. A. Anthouli-Anagnostopoulou

General Department of Essential Medical Sub­jects, Faculty of Health and Caring Professions, Technological Educational Institution, Athens, Greece

Παραπομπή – Citation

Ανθούλη-Αναγνωστοπούλου,Φ. : Ρευματοειδής Αρθρίτις: Παθογένεια και Νέες Θεραπευτικές Προσεγγίσεις, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 20: 11-24 (2002)

Anthouli-Anagnostopoulou,F. : Rheumatoid Arthritis: Patho­genesis and New Therapeutic Ap­proaches, Epitheorese Klin. Farmakol. Farmakokinet. 20: 11-24 (2002)

Ημερομηνία Δημοσιευσης – Publication Date
10 Ιανουαρίου 2002 – 2002-01-10
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Ρευματοειδής αρθρίτις, παθοφυσιολογικές οδοί, θεραπεία με  τροποποιημένα αντιρρευματικά φάρμάκα, συνδυαστική θεραπεία, TNF-τροποποιητές της βιολογικής απάντησης, παθογένεια
Rheumatoid arthritis, pathophysiological pathways, DRMADs monotherapy, combination therapy, TΝF biological-response modifiers, pathogenesis
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

H ρευματοειδής αρθρίτις (ΡΑ) είναι ακρωτηριαστική αυτοάνοσος νόσος χαρακτηριζόμενη από φλεγμονή και καταστροφή του αρθρικού ιστού. Αποτελεί τη συχνότερη μορφή φλεγμονώδους αρθρίτιδας, με ουσιαστική κοινωνική επίδραση όσον αφορά το βαθμό της αναπηρίας, την απώλεια της λειτουργικότητας και την οικονομική επιβάρυνση. Αν και η παθογένεια της ρευματοειδούς αρθρίτιδας δεν έχει πλήρως διευκρινισθεί, κατά την τελευταία δεκαετία, πρόοδοι στην κατανόηση της παθογένειας της νόσου, όπως και η ανάπτυξη της βιοτεχνολογίας, έχουν καταστήσει δυνατή την επιλεκτική στόχευση των παθογενετικών στοιχείων της νόσου. Νέες θεραπευτικές προσεγγίσεις, βασιζόμενες στους μηχανισμούς αυτούς, έχουν αποδείξει την αποτελεσματικότητα της επιθετικής θεραπευτικής αντιμετώπισης σε ασθενείς με ενεργό νόσο. Στην ανασκόπηση αυτή περιγράφονται αφ’ ενός μεν νέες απόψεις σχετικές με την κατανόηση της παθοφυσιολογίας της ρευματοειδούς αρθρίτιδος, αφ’ ετέρου δε νέες θεραπευτικές αγωγές της νόσου. Οι μελλοντικές έρευνες αποσκοπούν στην πρώιμη θεραπευτική παρέμβαση της νόσου και στην ελάττωση της μακροχρόνιας ανικανότητας και καταστροφής της άρθρωσης. Η καταλληλότερη αντιμετώπιση φαίνεται να είναι η έγκαιρη διάγνωση και αναγνώριση των πασχόντων με ενεργό νόσο και η βελτίωση των τροποποιημένων αντιρρευματικών φαρμάκων (DMARDs). Οι νέες εφαρμοζόμενες βιολογικές θεραπείες υπόσχονται ουσιαστική βελτίωση στην κλινική συμπτωματολογία και στην εξέλιξη της πορείας της νόσου.

Rheumatoid arthritis (RA) is a crippling, autoimmune disease, and is characterized by in­flammation and destruction of joint tissue. It is the most common form of inflammatory arthritis, and has a substantial societal effect in terms of cost, disability, and lost of productivity. Although the pathogenesis of rheumatoid arthritis remains incom­pletely understood, the past decade, advances in the understanding of the pathogenesis of the dis­ease as well as improved biotechnology has en­abled selective targeting of the pathogenic elements of disease. New therapies, based on the cellular and molecular mechanisms involved have shown the efficacy of aggressive treatment of patients with active disease. In this review, are discussed on the one hand new considerations in the understanding of the pathophysiology of inflammatory synovitis in rheumatoid arthritis, and on the other hand new therapy modalities of the disease. Future studies will be directed at early therapeutic intervention in the disease process and in the reduction of long–term disability and joint damage. Optimal management appears to be the early diagnosis and identification of patients with active disease and the improvement of disease-modifying drugs (DMARDs). Newly ap­plied biologic agents in the treatment of rheumatoid arthritis are promising substantial improvement in signs and symptoms as well as in disease progres­sion.

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