Τόμος 20 (2002) – Τεύχος 3+3Σ – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 20 (2002) – Issue 3+3Σ – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Ταχείες μη Γενωμικές Δράσεις των Γλυκοκορτικοειδών Ορμονών

Rapid non Genomic Effects of Glucocorticoid Hormones

Συγγραφέας – Author

Αμαλία Τσολακίδου, Παρασκευή Μουτσάτσου

Εργαστήριο Βιολογικής Χημείας, Ιατρική Σχολή, Πανεπιστήμιο Αθηνών, Αθήνα – Ελλάς

A. Tsolakidou, P. Moutsatsou

Laboratory of Biological Chemistry, Medical School, University of Athens, M. Asias 75, Goudi, 115 27 Athens, Greece
Παραπομπή – Citation

Τσολακίδου,Α., Μουτσάτσου,Π. : Ταχείες μη Γενωμικές Δράσεις των Γλυκοκορτικοειδών Ορμονών, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 20: 165-172 (2002)

Tsolakidou,A., Moutsatsou,P. : Rapid non Genomic Effects of Glucocorticoid Hormones, Epis­temological and Psycho­dynamic Aspects, Epitheorese Klin. Farmakol. Farmakokinet. 20: 165-172 (2002)

Ημερομηνία Δημοσιευσης – Publication Date
10 Αυγούστου 2002 – 2002-08-10
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords
Γλυκοκορτικοειδή, υποδοχέας γλυκοκορτικοειδών, μη γενωμικές δράσεις στεροειδών, ταχείες δράσεις στεροειδών
Glucocorticoids, glucocorticoid receptor, non genomic effects of steroids, rapid effects of steroids
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Μέχρι σήμερα, η δράση των στεροειδών ορμονών απεδίδετο κυρίως στην πρόσδεσή τους με τον ενδοκυτταρικό υποδοχέα και την ενεργοποίηση της μεταγραφής γονιδίων στον πυρήνα, με αποτέλεσμα αλλαγές στη σύνθεση νέων πρωτεϊνών.  Η γενωμική θεωρία της δράσης των στεροειδών ορμονών, μπορεί να εξηγήσει ικανοποιητικά αλλαγές σε αργές μεταβολικές και αναπτυξιακές διαδικασίες, όμως συναντά δυσκολίες στην εξήγηση ταχέων δράσεων των στεροειδών ορμονών στον οργανισμό που δεν παρεμποδίζονται από αναστολείς της βιοσύνθεσης RNA. Οι ταχείες δράσεις των γλυκοκορτικοειδών εμφανίζονται στο Κεντρικό Νευρικό Σύστημα, στο Περιφερικό Νευρικό Σύστημα, στην υπόφυση, καθώς και σε άλλα όργανα και κυτταρικά συστήματα. Ο νέος αυτός μηχανισμός δράσης των στεροειδών ορμονών και η φύση του εμπλεκόμενου μεμβρανικού υποδοχέα αξίζουν περαιτέρω διερεύνησης.

According to the traditional model, glu­cocorticoid hormones exert their phenotypic effects by way of binding to intracellular receptors, modula­tion of gene transcription and of protein synthesis. These effects are delayed and are blocked by in­hibitors of RNA and protein synthesis. Therefore, this classic theory can not explain sufficiently the rapid effects of glucocorticoids presented in the central nervous system, the peripheral nervous system and other organs and cell systems. This novel mechanism of action of the glucocorticoids and the nature of the involved membrane receptor warrants further investigation.

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