Τίτλος – Title
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Ταχείες μη Γενωμικές Δράσεις των Γλυκοκορτικοειδών Ορμονών Rapid non Genomic Effects of Glucocorticoid Hormones |
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Συγγραφέας – Author
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Αμαλία Τσολακίδου, Παρασκευή Μουτσάτσου Εργαστήριο Βιολογικής Χημείας, Ιατρική Σχολή, Πανεπιστήμιο Αθηνών, Αθήνα – Ελλάς A. Tsolakidou, P. Moutsatsou Laboratory of Biological Chemistry, Medical School, University of Athens, M. Asias 75, Goudi, 115 27 Athens, Greece
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Παραπομπή – Citation
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Τσολακίδου,Α., Μουτσάτσου,Π. : Ταχείες μη Γενωμικές Δράσεις των Γλυκοκορτικοειδών Ορμονών, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 20: 165-172 (2002) Tsolakidou,A., Moutsatsou,P. : Rapid non Genomic Effects of Glucocorticoid Hormones, Epistemological and Psychodynamic Aspects, Epitheorese Klin. Farmakol. Farmakokinet. 20: 165-172 (2002) |
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Ημερομηνία Δημοσιευσης – Publication Date
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10 Αυγούστου 2002 – 2002-08-10
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Γλυκοκορτικοειδή, υποδοχέας γλυκοκορτικοειδών, μη γενωμικές δράσεις στεροειδών, ταχείες δράσεις στεροειδών
Glucocorticoids, glucocorticoid receptor, non genomic effects of steroids, rapid effects of steroids
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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Μέχρι σήμερα, η δράση των στεροειδών ορμονών απεδίδετο κυρίως στην πρόσδεσή τους με τον ενδοκυτταρικό υποδοχέα και την ενεργοποίηση της μεταγραφής γονιδίων στον πυρήνα, με αποτέλεσμα αλλαγές στη σύνθεση νέων πρωτεϊνών. Η γενωμική θεωρία της δράσης των στεροειδών ορμονών, μπορεί να εξηγήσει ικανοποιητικά αλλαγές σε αργές μεταβολικές και αναπτυξιακές διαδικασίες, όμως συναντά δυσκολίες στην εξήγηση ταχέων δράσεων των στεροειδών ορμονών στον οργανισμό που δεν παρεμποδίζονται από αναστολείς της βιοσύνθεσης RNA. Οι ταχείες δράσεις των γλυκοκορτικοειδών εμφανίζονται στο Κεντρικό Νευρικό Σύστημα, στο Περιφερικό Νευρικό Σύστημα, στην υπόφυση, καθώς και σε άλλα όργανα και κυτταρικά συστήματα. Ο νέος αυτός μηχανισμός δράσης των στεροειδών ορμονών και η φύση του εμπλεκόμενου μεμβρανικού υποδοχέα αξίζουν περαιτέρω διερεύνησης. According to the traditional model, glucocorticoid hormones exert their phenotypic effects by way of binding to intracellular receptors, modulation of gene transcription and of protein synthesis. These effects are delayed and are blocked by inhibitors of RNA and protein synthesis. Therefore, this classic theory can not explain sufficiently the rapid effects of glucocorticoids presented in the central nervous system, the peripheral nervous system and other organs and cell systems. This novel mechanism of action of the glucocorticoids and the nature of the involved membrane receptor warrants further investigation. |
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Αναφορές – References
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