Τόμος 17 (1999) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 17 (1999) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Γενετική της Σχιζοφρενείας

The Genetics of Schizophrenia

Συγγραφέας – Author

Ευμορφία Κούκια, Σταύρος Τ. Πλέσσας

Τμήμα Νοσηλευτικής, Πανεπιστήμιο Αθηνών, Αθήνα, Ελλάς

Evmorfia Koukia, Stavros T. Plessas

Department of Nursing, University of Athens, Athens, Greece

Παραπομπή – Citation

Κούκια,Ε., Πλέσσας,Σ.Τ.,  : Γενετική της Σχιζοφρενείας , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 17 : 5-12 (1999)

Koukia,E., Plessas,S.T., : The Genetics of Schizophrenia, Epitheorese Klin. Farmakol. Farmakokinet. 17: 5-12 (1999)

Ημερομηνία Δημοσιευσης – Publication Date
05-03-1999-03-05
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €)
Digital Type: pdf (15 )
pharmakonpress[at]pharmakonpress[.]gr
Λέξεις κλειδιά – Keywords

Σχιζοφρένεια, χρωμόσωμα, γονίδιο, γενετικός τόπος, μελέτες ανάλυσης, μελέτες συσχέτισης, μελέτες με διδύμους, μελέτες με οικογένειες, μελέτες υιοθετημένων ατόμων, υποδοχέας ντοπαμίνης

Schizophrenia, chromosome, gene, locus, linkage studies, association studies, twin studies, family studies, adoption studies, dopamine receptor
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Η γενετική της σχιζοφρενείας αποτελεί αντικείμενο πολλών ερευνών. Πρόσφατες μελέτες μοριακής γενετικής, όπως οι μελέτες ανάλυσης και συσχέτισης, εξετάζουν την ύπαρξη γονιδίων πιθανόν σχετιζόμενων με τη σχιζοφρένεια. Αυτές οι μελέτες, αν και ανέδειξαν αρκετούς πιθανούς παράγοντες, δεν απέδειξαν τα ακριβή γονίδια τα οποία ευθύνονται για την εμφάνιση της ασθενείας. Εξ άλλου, μελέτες με διδύμους, με οικογένειες και με υιοθετημένα άτομα, παρέχουν αρκετές αποδείξεις για το γενετικό ρόλο της σχιζοφρενείας. Επίσης, οι μελέτες αυτές έδειξαν ότι ορισμένοι περιβαλλοντικοί παράγοντες διαδραματίζουν σημαντικό ρόλο στη γένεση της σχιζοφρενείας. Η έρευνα η οποία αφορά στα γονίδια τα υπεύθυνα για τη σχιζοφρένεια και ο τρόπος της κληρονομικότητάς τους, αποτελούν προκλήσεις που καλούνται να αντιμετωπίσουν οι επιστήμονες οι οποίοι ασχολούνται με τη γενετική της σχιζοφρενείας.

Recent molecular genetic studies such as linkage studies and association studies search for schizophrenia susceptibility genes. Although these studies have identified several potential factors, they have until now, been unable to demonstrate the genes responsible for schizophrenia. On the other hand, twin, family and adoption studies have provided strong evi­dence for the role of genetic factors in schizo­phrenia. Additionally, they have shown that environmental factors have an important role in the origin of schizophrenia. The search for genes predisposing to schizophrenia and the mode of inheritance constitute the many chal­lenges facing scientist, who undertake schizo­phrenia genetics research.

Αναφορές – References
1. Kendler K.S., Diehl S.R.: The Genetics of Schizophre­nia: A current Genetic-Epidemiological Perspective. Schizophr. Bull. 19(2): 261-284 (1993)

2. Basset A.S., McGillivray B.C., Jones B.D. Pantzar J.T.: Partial trisomy of chromosome 5 cosegregating with schizophrenia. Lancet I: 799-801 (1988)

3. Sherrington R., Brynjolfsson J., Pertusson H., et al: localization of a susceptibility locus of schizophrenia on chromosome 5. Nature 336: 164-167 (1988)

4. Kaufman C.A., Delise E., Lehner T., Gillian T.C.: Physical mapping, linkage analysis of the putative schizophrenia locus on chromosome5q. Schizophr. Bull. 15: 441-452 (1989)

5. Aschauer H.N., Aschauer-Trieber G., Isenberg K.E., et al: No evidence for linkage between chromosome 5 markers and schizophrenia. Hum. Hered. 40: 109-115 (1990)

6. Datera-Wadleigh S.D., Goldin L.R., Sherrington R., et al: Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders. Nature 340: 391-393 (1989)

7. Lander E., Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11: 241-247 (1995)

8. Wang S., Sun C.E., Walczak C.A., Ziegle J.C., et al: Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature Genet. 10: 41-46 (1995)

9. Schwab S.G., Albus M., Hallmayer J., et al: Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sibpair linkage analysis. Nature Genet. 11: 325-327 (1995)

10. Straub R.E., McLean C.J., et al: A potential vulnerabil­ity locus of schizophrenia on chromosome 6pter-p22: evidence for genetic heterogeneity. Nature Genet. 11: 267-293 (1995)

11. Garner C., Kelly M., et al: Linkage analyses of schizo­phrenia to chromosome 6p24-22: An attempt to replicate. Am. J. Med. Gen. 67: 595-610 (1996)

12. Riley B.P., Rajagopalan S., Mogudi-Carter M., Jenkins T., Williamson R.: No evidence for linkage of chromosome 6p markers to schizophrenia in Southern African Bantu-speaking families. Psych. Gen. 6: 41-49 (1996)

13. Pulver A.E., Lasseret V.K., Kasch L., et al: Schizo­phre­nia: A genome scan targets chromosome 3p and 8p as potential sites for susceptibility genes. Am. J. Med. Gen. 60: 252-260 (1995)

14. Kender K.S., McLean C.J., et al: Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am. J. Psych. 153: 1534-1540 (1996)

15. Moises H.W., Yang L., Kristbjarnarson H., et al: An international two-stage genome-wide search for schizo­phre­nia susceptibility genes. Nature Genet. 11: 321-324 (1995)

16. Coon H., Holik J., Hoff M., et al: Analysis of chromo­some 22 markers in 9 schizophrenia pedigrees. Am. J. Med. Genet. Neuropsychiat. Genet. 54: 72-79 (1994)

17. Vallada H.P., Collier D., et al: Linkage studies on chromosome 22 in familial schizophrenia. Am. J. Med. Genet. 60(2): 139-146 (1995)

18. Kalsi G., Brynjolfsson J., et al: Linkage analysis of chromosome 22q12-13 in a United Kingdom / Icelandic sample of 23 multiplex schizophrenia families. Am. J. Med. Gen. 60: 298-301 (1995)

19. Riley B.P., Mogudi-Carter M., Jenkins T., Williamson R.: No evidence for linkage of chromosome 22p markers to schizophrenia in Southern African Bantu-speaking families. Am. J. Med. Gen. 67: 515-522 (1998)

20. Levinson D.F., Mantani M.M., et al: Genome scan of schizophrenia. Am. J. Psychiatry 155(6): 741-750 (1998)

21. Crow D.J., Delisi L.E., Johnstone E.C.: Concordance by sex in sibling pairs with schizophrenia is paternally inherited: Evidence for a pseudoautosomal locus. Br. J. Psychiatry 155: 92-97 (1998)

22. Crow D.J., Delisi L.E., et al: An examination of linkage of schizophrenia and schizoaffective disorder to the pseu­doautosomal region (Xp22.3). Br. J. Psych.: 159-164 (1994)

23. Nonomura Y., Yoneda H., et al: A study of pseu­doautosomal region in sib-pairs with schizophrenia. Psychiatric Gen. 2: 89 (1991)

24. Ascherson P., Parfitt E., et al: No evidence for a pseudoautosomal locus for schizophrenia linkage analysis of multiply affected families. Br. J. Psychiatry 161: 63-68 (1992)

25. Mowry B.J., Nancarrow D.J., Levinson D.F.: The molecular genetics of schizophrenia: an update. Aust. N. Z. J. Psychiatry 31(5): 704-713 (1997)

26. Coon H., Jensen S., Holik J., et al: Genomic scan for genes predisposing to schizophrenia. Am. J. Med. Genet. 54: 59-71 (1994)

27. McGuffin P., Sturt E.: Genetic markers in schizophre­nia. Hum. Hered. 36: 65-88 (1986)

28. Wright P., Donaldson P.T., et al: Immunogenetic markers in schizophrenia: HLA A9 revisited. Schizophr. Res. 15: 50 (1995)

29. Campion D., Leboyer M., et al: Relationship of HLA to schizophrenia not supported in multiplex families. Psychiatric Res. 41: 99-105 (1992)

30. Wright P., Donaldson P.T., Underhill J., et al: Schizo­phrenia is negatively associated with HLA DR4 in probands and their mothers. Schizophr. Res. 15: 103 (1995)

31. Nimgaonkar V.L., Ganguli R., Washington S.S., et al: Schizophrenia and porphobilinogen: an association study. Schizophr. Res. 8: 51-58 (1992)

32. Owen M.J., Mant R., Parfitt E., et al: No association between RFLP’s at the porphobilinogen deaminase gene and schizophrenia. Hum. Genet. 90: 131-132 (1992)

33. Karayiorgou M., Kasch L., Lasseter V.K., et al: Report from the Maryland epidemiology schizophrenia linkage study: no evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model. Am. J. Med. Genet. 54: 345-353 (1994)

34. Nanco S., Fukuda R., Hattori M., et al: No evidence of linkage or allelic association of schizophrenia with DNA markers at pericentric region of chromosome 9. Biol. Psych. 36: 589-594 (1994)

35. Byerly W., Plaetke R., et al: Linkage analysis of six schizophrenia pedigrees with ISO DNA markers. Schizophr. Res. 4: 274-275 (1991)

36. Jensen S., Plaetke R., et al: Linkage analysis of schizophrenia, the D1 dopamine receptor gene and several flanking DNA markers. Hum. Hered. 43: 58-62 (1993)

37. Hellmayer J., Maier W., et al: No evidence of linkage between the dopamine D2 receptor gene of schizophrenia. Psychiatr. Res. 53: 203-215 (1994)

38. Su Y., Burke J., et al: Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families. Arch. Gen. Psychiatry 50: 205-211 (1993)

39. Mant R., Williams J., et al: Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. Am. J. Med. Genet. 54: 21-26 (1994)

40. Owen M.J., Williams J., et al: Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Am. J. Med. Genet. 30: 708-709 (1993)

41. Maier W., Schwab S., et al: Absence of linkage between schizophrenia and the dopamine D4 receptor gene. Psychiatr. Res. 53: 77-86 (1994)

42. Shaikh S., Gill M., Owen M., et al: Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. Am. J. Med. Gen. 54: 8-11 (1994)

43. Prescott C.A., Gottesman I.I.: Genetically mediated vulnerability to schizophrenia. Psychiatric Clin. North America 16: 245-267 (1993)

44. Onstad S., Skre I., Torgersen S., Kringlen E.: Twin concordance for DSM-III-R schizophrenia. Acta Psych. Scan. 83: 395-401 (1991)

45. Stabenau J.R., Pollin W.: Heredity and environment in schizophrenia, revisited: the contribution of twin and high-risk studies. J. Nerv. Ment. Dis. 181: 29-297 (1993)

46. Gottesman I.I., Bertelsen A.: Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fisher’s Danish identical and fraternal twins. Arch. Gen. Psychiatry 46: 867-872 (1989)

47. Kringlen E., Cramer G.: Offspring of monozygotic twins discordant for schizophrenia. Arch. Gen. Psychiatry 46: 867-872 (1989)

48. Kendler K.S., McGuire M., Gruenberg A.M., et al: The Roscommon family study. I. Methods, diagnosis of probands and risk of schizophrenia in relatives. Arch. Gen. Psychiatry 50: 527-540 (1993)

49. Gottesman I.I.: Origins of schizophrenia: past and prologue. In: (Plomin R., McClearn G.E., eds) Nature, Nurture and Psychology. Washington, D.C.: Am. Psych. Ass.: 231-244 (1993)

50. Kringlen E.: Genetic aspects of schizophrenia with special emphasis on twin research. In: (Kringlen et al, eds) Etiology of Mental Disorders. Oslo: Department of Psychia­try, University of Oslo: 63-79 (1990)

51. Tienari P., Wynne L.C., Moring J., et al: Genetic vulnerability or family environment? Implications from Finnish adoptive family study of schizophrenia. Psychiatr. Fenn. 24: 23-41 (1993)

52. Tienari P., Wynne L.C., Moring J., et al: The Finnish adoptive family study of schizophrenia. Implications for family research. Br. J. Psychiatr. 164(Sup. 23): 20-26 (1994)

53. Kety S.S.: Mental illness in the biological and adoptive relatives of schizophrenic adoptees, findings relevant to genetic and environmental factors in etiology. Am. J. Psychiatry 140: 720-727

54. Kety S.S., Wender P.H., Jacobson B., et al: Mental ill­ness in the biological and adoptive relatives of schizo­phrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Arch. Gen. Psychiatry 51: 442-455 (1994)

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
Chemical Abstracts

Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
Γλώσσα Πλήρους Κειμένου –
Full Text Language
Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (70 €) –
Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr
Έντυπη Μορφή (70 € + έξοδα αποστολής)
Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr

 

Προσθέστε στους σελιδοδείκτες το μόνιμο σύνδεσμο.

Τα σχόλια είναι απενεργοποιημένα.