Τόμος 16 (1998) – Τεύχος 2+2Σ – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 16 (1998) – Issue 2+2Σ – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Αθανάσιος Δ. Καλδής, Στέλιος Μ. Πιπεράκης

Ινστιτούτο Βιολογίας Ε.Κ.Ε.Φ.Ε Δημόκριτος, 153 10 Αγία Παρασκευή, Αθήνα, Ελλάς

A.D. Kaldis, S.M. Piperakis

Institute of Biology, NCSR Demokritos, Agia Paraskevi, Athens, Greece

2. Halliwell B.: Free radicals and antioxidants: a personal view. Nutr. Rev. 52: 253-265 (1994)

3. Ames B.N.: Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221: 1256-1264 (1983)

4. Demple B., Harrison L.: Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63: 915-948 (1994)

5. Totter J.R.: Spontaneous cancer and its possible relationship to oxygen metabolism. Proc. Natl. Acad. Sci. USA 77: 1763-1767 (1980)

6. Halliwell B., Gutteridge J.M.C.: The antioxidants of human extracellular fluids. Arch. Biochem. Biophys. 280: 1-8 (1990)

7. Bolann B.J., Ulvik R.J.: On the limited ability of superoxide to release iron from ferritin. Eur. J. Biochem. 193: 899-904 (1990)

8. Gutteridge J.M.C.: Iron promoters of the Fenton reaction and lipid peroxidation can be released from heamoglobin by peroxides. FEBS Lett. 201: 291-295 (1986)

9. Halliwell B., Aruoma O.I.: DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett. 281: 9-19 (1991)

10. Van den Akker E., Lutgerink J.T., Lafleur M.V.M., Joenje H., Retel J.: The formation of one-G deletions as a consequence of single-oxygen-induced DNA damage. Mutat. Res. 309: 45-52 (1994)

11. Hruszkewycz A.M.: Lipid peroxidation and mt DNA degeneration. A hypothesis. Mutat. Res. 275: 234-248 (1992)

12. Wagner J.R., Hu C.C., Ames B.N.: Endogenous oxidative damage of deoxycytidine in DNA. Proc. Natl. Acad. Sci. USA 89: 3380-3384 (1992)

13. Stadtman E.R.: Protein oxidation and aging. Science 257: 1220-1224 (1992)

14. Stadtman E.R.: Oxidation of free amino acids residues in proteins by radiolysis and by metal-catalysed reactions. Annu. Rev. Biochem. 62: 797-821 (1993)

15. Mazdak C., Sarasin A.: Mutation spectrum following transfection of ultraviolet-irradiated single-stranded or double-stranded shuttle vector DNA into monkey cells. J. Mol. Biol. 218: 667-673 (1991)

16. Wood R.D.: DNA repair in eukaryotes. Annu. Rev. Biochem. 65: 135-167 (1996)

17. Kamiya H., Ueda T., Ohgi T., Matsukage A., Kasai H.: Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res. 23: 761-766 (1995)

18. Maccabee M., Evans J.S., Glackin M., Hatahet Z., Wallace S.S.: Pyrimidine ring fragmentation products. Effects of lesion structure and sequence context on mutagenesis. J. Mol. Biol. 236: 514-530 (1994)

19. Ribeiro D.T., Costa de Oliveira R., Di Mascio P., Menck C.F.M.: Singlet oxygen induces predominantly G to T transversions on a single-stranded shuttle vector replicated in monkey cells. Free Radical Res. 21: 75-83 (1994)

20. Feig D.I., Loeb L.A.: Mechanismes of mutations by oxidative DNA damage: reduced fidelity of mammalian DNA polymerase beta. Biochemistry 32: 4466-4473 (1993)

21. Weinberg R.A.: How cancer arises. Sci. Am. 275: 32-40 (1996)

22. Malinow M.R., Bardana E.J., Pirofsky B., Craig S., McLaughlin P.: Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid. Science 216: 415-417 (1982)

23. Tamura G., Gold C., Ferro-Luzzi A., Ames B.N.: Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. Proc. Natl. Acad. Sci. USA 77: 4961-4965 (1980)

24. Levin D.E., Hollstein M., Christman M.F., Schwiers E., Ames B.N.: A new Salmonela tester strain (TA 102) with A X T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. USA 79: 7445-7449 (1982)

25. Hendricks J.D., Sinnhuber R.O., Loveland P.M., Pawlowski N.E., Nixon J.E.: Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii). Science 208: 309-311 (1980)

26. Bird R.P., Draper H.H., Basrur P.K.: Effect of malonaldehyde and acetaldehyde on cultured mammalian cells. Production of micronuclei and chromosomal aberrations. Mutat. Res. 101: 237-246 (1982)

27. Kritchevsky D., Fink D.J.: Introduction to the workshop on fat and cancer. Cancer Res. 41: 3684 (1981)

28. Jones D.P., Eklow L., Thor H., Orrenius S.: Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2. Arch. Biochem. Biophys. 210: 505-516 (1981)

29. Williamson J.M., Boettcher B., Meister A.: Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Proc. Natl. Acad. Sci. USA 79: 6246-6249 (1982)

30. Novi A.M.: Regression of aflatoxin B1-induced hepatocellular carcinomas by reduced glutathione. Science 212: 541-542 (1981)

31. Ames B.N., Cathcart R., Schwiers E., Hochstein P.: Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc. Natl. Acad. Sci. USA 78: 6858-6862 (1981)

32. Willett W.C.: Diet and health: what should we eat? Science 264: 532-537 (1994)

33. Smith A.G., Francis J.E., Carthew P.: Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah-responsive C57BL/10ScSn mice. Carcinogenesis 11: 437-444 (1990)

34. Harman D.: Free radical theory of aging: history. Mutat. Res. 275: 257-266 (1992)

35. Arnheim N., Cortopassi G.: Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat. Res. 275: 157-167 (1992)