Τόμος 15 (1997) – Τεύχος 3 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 15 (1997) – Issue 3 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Στοιχεία Χρονοφαρμακολογίας

Elementary Chronopharmacology

Συγγραφέας – Author

Βασίλης Κόκκας* και M. Τσολάκη**

*Ερ­γα­στή­ριο Φαρ­μα­κο­λο­γί­ας και **Γ’ Νευ­ρο­λο­γι­κή Κλι­νι­κή, Ια­τρι­κό Τμή­μα, Α­ρι­στο­τέ­λει­ο Πα­νε­πι­στή­μιο Θεσ­σα­­λο­νί­κης, Ελ­λάς

B. Kokkas1 and M. Tsolaki2

1 Laboratory of Pharmacology and 2 Third Neu­rologi­cal Clinic, School of Medicine, Aristotelian Univer­sity of Thessaloniki, Greece

Παραπομπή – Citation

Κόκκας,Β., Τσολάκη,Μ.  : Στοιχεία Χρονοφαρμακολογίας , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 15 :  (1997)

Kokkas,B., Tsolaki,M. : Elementary Chronopharmacology, Epitheorese Klin. Farmakol. Farmakokinet. 15 :  (1997)

Ημερομηνία Δημοσιευσης – Publication Date
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords

Χρο­νο­βιο­λο­γί­α, χρο­νο­φαρ­μα­κο­κι­νη­τι­κή, χρο­νο­φαρ­μα­κολογία, χρο­νο­θε­ρα­πευ­τι­κή

Chronobiology, chronopharmacology, chronopharmacokinetics, chronothera­peutics
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Οι βιο­ρυθ­μοί κά­θε ορ­γα­νι­σμού α­ντι­κα­το­πτρί­ζουν μί­α πε­ριο­δι­κό­τη­τα των λει­τουρ­γιών του με α­πώ­τε­ρα ση­μεί­α την α­κρό­φα­ση και τη βα­θύ­φα­ση. Η χρο­νο­φαρ­μα­κο­λο­γί­α με­λε­τά τις πρό­σκαι­ρες με­τα­βο­λές που α­φο­ρούν την κι­νη­τι­κή, τις ε­νέρ­γει­ες και την το­ξι­κό­τη­τα των φαρ­μά­κων στις διά­φο­ρες φά­σεις των βιο­ρυθ­μών. Α­σχο­λεί­ται, ό­μως, και με τις ε­πι­δρά­σεις των φαρ­μά­κων στους βιο­ρυθ­μούς που εμ­φα­νί­ζει κά­θε ορ­γα­νι­σμός. Οι με­λέ­τες αυ­τές έ­χουν δύ­ο σκο­πούς, την ε­πι­λο­γή της κα­λύ­τε­ρης ώ­ρας για τη χο­ρή­γη­ση ε­νός φαρ­μά­κου ώ­στε να εί­ναι α­πο­τε­λε­σμα­τι­κότερο και την α­να­κά­λυ­ψη φαρ­μά­κων που θα δίδουν τη δυ­να­τό­τη­τα πα­ρέμ­βα­σης στους βιο­ρυθ­μούς, ό­ταν αυ­τοί δια­τα­ράσ­σο­νται πρό­σκαι­ρα ή μό­νι­μα.

Cicardian or circannual biological rythms of endogenous origin constitute a temporal structure of organism in all animals species includ­ing man. Chronopharmacology consists the study of temporal variations of the activity, toxicity and kinetics of drugs according to their time of admini­stration. Chronopharmacology also concerns the study of possible alterations of the temporal struc­ture of the organism receiving the drug. The aim of this section of pharmacology is to documentize qualitive and quantitive temporal changes of the efficiency of drugs which lead to a better use of them in the treatment of disease. Another aim is to find substances that will be able to influence such cicardian biological rythms.

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