Τόμος 15 (1997) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 15 (1997) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Μοριακή Φαρμακολογία των G-Πρωτεϊνών

Molecular Pharmacology of G-Proteins

Συγγραφέας – Author

Α. Μακρυγιαννάκης και Α. Γραβάνης

Εργαστήριο Φαρμακολογίας, Τμήμα Ιατρικής, Πανεπιστήμιο Κρήτης, 711 10 Ηράκλειο, Ελλάς

A. Makrygiannakhs and A. Gravanis

Laboratory of Pharmacology, School  of Medicine, University of Kreta, Iraklion 711 10, Greece

Παραπομπή – Citation

Μακρυγιαννάκης,Α., Γραβάνης,Α.  : Μοριακή Φαρμακολογία των G-Πρωτεϊνών , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 15 :  17-28 (1997)

Makrygiannakhs,A., Gravanis,A. : Molecular Pharmacology of G-Proteins, Epitheorese Klin. Farmakol. Farmakokinet. 15 : 17-28 (1997)

Ημερομηνία Δημοσιευσης – Publication Date
10-02-1997
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords

G-πρωτεΐνες, υποδοχείς, μοριακή φαρμακολογία, παθοφυσιολογία

G-proteins, receptors, molecular pharmacology, pathophysiology
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Ο ρό­λος των ε­τε­ρο­τρι­με­ρών GTP-συν­δε­ου­σών πρω­τε­ϊ­νών (G-πρω­τε­ϊ­νών) έ­χει α­πο­κτή­σει ση­μα­ντι­κό εν­δια­φέ­ρον τα τε­λευ­ταί­α χρό­νια. Ο α­ριθ­μός των G-πρω­τε­ϊ­νών που ταυ­το­ποι­ή­θη­σαν στα διά­φο­ρα εί­δη κα­θώς και ο α­ριθ­μός των κυτ­τα­ρι­κών λει­τουρ­γιών οι ο­ποίες ρυθ­μί­ζο­νται α­πό αυ­τές έ­χει πολ­λα­πλα­σια­σθεί. Η α­να­σκό­πη­ση αυ­τή πα­ρου­σιά­ζει πρό­σφα­τα δε­δο­μέ­να σχε­τι­κά με τη δο­μή, τη λει­τουρ­γί­α και την ποι­κι­λί­α των G-πρω­τε­ϊ­νών. Ι­δια­ί­τε­ρη έμ­φα­ση δί­δε­ται στα προ­βλή­μα­τα ε­ξει­δί­κευ­σης της σύν­δε­σης των υ­πο­δο­χέ­ων με τις διά­φο­ρες G-πρω­τε­ΐ­νες και στη συμ­με­το­χή των α­νώ­μα­λων G-πρω­τε­ϊ­νών στις αν­θρώ­πι­νες α­σθέ­νει­ες.

The role of eterotrimeric guanine nucleotide binding proteins (G-proteins) is becom­ing increasingly interesting the last years. Multiple G-proteins have been identified in mammalians, intervertebrates, plants and single-celled eykaryotes and the number of cellular functions shown to be regulated by G-proteins has been increased correspondingly. This review summa­rizes recent progress in our understanding  of G-proteins structure, function and diversity. Particu­lar emphasis is given to the problem of defining specificity in coupling of receptors to various G-proteins and the involvement of abnormal G-pro­teins in human disease.

Αναφορές – References1.
  1. Bourne H.R., Sanders D.A., McCormick F.: The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348: 125-132 (1990)
  2. Bourne H.R., Sanders D.A., McCormick F.: The GTPase superfamily: conserved structure and molecular mechanism. Nature 349: 117-127 (1991)
  3. Simon M.I., Strathmann M.P., Gautam N.: Diversity of G proteins in signal transduction. Science 252: 802-808 (1991)
  4. Kaziro Y., Itoh H., Kozasa T., Nakafuku M., Satoh T.: Structure and function of signal-transducing GTP-binding proteins. Annu Rev Biochem 60: 349-400 (1991)
  5. Kikkawa S., Takahashi K., Takahashi K., Shimada N., Ui M., Kimura N., Katada T.: Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins. J. Biol. Chem. 265: 21536-21540 (1990)
  6. Randazzo P.A., Northup J.K., Kahn R.A.: Activation of a small GTP-binding protein by nucleoside diphosphate kinase [see comments]. Science 254: 850-853 (1991)
  7. Kikkawa S., Takahashi K., Takahashi K., Shimada N., Ui M., Kimura N., Katada T.: Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins [published erratum appears in J. Biol. Chem. 266: 12795, 5 Jul. 1991]. J. Biol. Chem. 265: 21536-21540 (1990)
  8. Linder M.E., Ewald D.A., Miller R.J., Gilman A.G.: Purifi­cation and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J. Biol. Chem. 265: 8243-8251 (1990)
  9. Casey P.J., Fong H.K., Simon M.I., Gilman A.G.: Gz, a guanine nucleotide-binding protein with unique biochemical properties. J. Biol. Chem. 265: 383-390 (1990)
  10. Carty D.J., Padrell E., Codina J., Birnbaumer L., Hilde­brandt J.D., Iyengar R.: Distinct guanine nucleotide binding and release properties of the three Gi proteins. J. Biol. Chem. 265: 6268-6273 (1990)
  11. Lee E., Taussig R., Gilman A.G.: The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits. J. Biol. Chem. 267: 1212-1218 (1992)
  12. Katada T., Kusakabe K., Oinuma M., Ui M.: A novel mechanism for the inhibition of adenylate cyclase via inhibi­tory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins. J. Biol. Chem. 262: 11897-11900 (1987)
  13. Tang W.J., Gilman A.G.: Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits., Science 254: 1500-1503 (1991)
  14. Federman A.D., Conklin B.R., Schrader K.A., Reed R.R., Bourne H.R.: Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature 356: 159-161 (1992)
  15. Axelrod J., Burch R.M, Jelsema C.L.: Receptor-medi­ated activation of phospholipase A2 via GTP-binding pro­teins: arachidonic acid and its metabolites as second mes­sengers. Trends Neurosci 11: 117-123 (1988)
  16. Kim D., Lewis D.L., Graziadei L., Neer E.J., Bar-Sagi D., Clapham D.E.: G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature 337: 557-560 (1989)
  17. Fung B.K.: Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits. J. Biol. Chem. 258: 10495-10502 (1983)
  18. Cerione R.A.: Reconstitution of receptor/GTP-binding protein interactions. Biochim. Biophys. Acta 1071: 473-501 (1991)
  19. Masters S.B., Stroud R.M., Bourne H.R.: Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng. 1: 47-54 (1986)
  20. Johnson G.L., Dhanasekaran N., Gupta S.K., Lowndes J.M., Vaillancourt R.R., Ruoho A.E.: Genetic and structural analysis of G protein alpha subunit regulatory domains. J. Cell Biochem. 47: 136-146 (1991)
  21. Masters S.B., Miller R.T., Chi M.H., Chang F.H., Beider­man B., Lopez N.G., Bourne H.R.: Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J. Biol. Chem. 264: 15467-15474 (1989)
  22. Graziano M.P., Gilman A.G.: Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. J. Biol. Chem. 264: 15475-15482 (1989)
  23. Woon C.W., Heasley L., Osawa S., Johnson G.L.: Mutation of glycine 49 to valine in the alpha subunit of GS results in the constitutive elevation of cyclic AMP synthesis. Biochemistry 28: 4547-4551 (1989)
  24. Navon S.E., Fung B.K.: Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction. J. Biol. Chem. 262: 15746-15751 (1987)
  25. Neer E.J., Pulsifer L., Wolf L.G.: The amino terminus of G protein alpha subunits is required for interaction with beta gamma. J. Biol. Chem. 263: 8966-8970 (1988)
  26. Higashijima T., Ross E.M.: Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go. J. Biol. Chem. 266: 12655-12661 (1991)
  27. Lee R.H., Lieberman B.S., Lolley R.N.: A novel complex from bovine visual cells of a 33,000-dalton phosphoprotein with beta- and gamma-transducin: purification and subunit structure. Biochemistry 26: 3983-3990 (1987)
  28. Reig J.A., Yu L., Klein D.C.: Pineal transduction. Adren­ergic-cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds beta gamma-complex of transducin. J. Biol. Chem. 265: 5816-5824 (1990)
  29. Fukada Y., Takao T., Ohguro H., Yoshizawa T., Akino T., Shimonishi Y.: Farnesylated gamma-subunit of photore­ceptor G protein indispensable for GTP-binding. Nature 346: 658-660 (1990)
  30. Ohguro H., Fukada Y., Takao T., Shimonishi Y., Yoshi­zawa T., Akino T.: Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II. EMBO J. 10: 3669-3674 (1991)
  31. Nakamura F., Ogata K., Shiozaki K., Kameyama K., Ohara K., Haga T., Nukada T.: Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. J. Biol. Chem. 266: 12676-12681 (1991)
  32. Jiang M., Pandey S., Tran V.T., Fong H.K.: Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. Proc. Natl. Acad. Sci. USA 88: 3907-3911 (1991)
  33. Olate J., Martinez S., Purcell P., Jorquera H., Codina J., Birnbaumer L., Allende J.: Molecular cloning and sequence determination of four different cDNA species coding for alpha-subunits of G proteins from Xenopus laevis oocytes. FEBS Lett 268: 27-31 (1990)
  34. Parks S., Wieschaus E.: The Drosophila gastrulation gene concertina encodes a G alpha-like protein. Cell 64: 447-458 (1991)
  35. Pottinger J.D., Ryba N.J., Keen J.N., Findlay J.B.: The identification and purification of the heterotrimeric GTP-binding protein from squid (Loligo forbesi) photoreceptors. Biochem. J. 279 (Pt 1): 323-326 (1991)
  36. Whiteway M., Hougan L., Dignard D., Bell L., Saari G., Grant F., O’Hara P., MacKay V.L, Thomas D.Y.: Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol 53 Pt 2: 585-590 (1988)
  37. Ma H., Yanofsky M.F., Meyerowitz E.M.: Molecular cloning and characterization of GPA1, a G protein alpha subunit gene from Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 87: 3821-3825 (1990)
  38. Warpeha K.M., Hamm H.E., Rasenick M.M., Kaufman L.S.: A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas. Proc. Natl. Acad. Sci. USA 88: 8925-8929 (1991)
  39. Ma H., Yanofsky M.F., Huang H.: Isolation and se­quence analysis of TGA1 cDNAs encoding a tomato G protein alpha subunit. Gene 107: 189-195 (1991)
  40. Spiegel A.M., Backlund P.S.,Jr, Butrynski J.E., Jones T.L., Simonds W.F.: The G protein connection: molecular basis of membrane association [published erratum appears in: Trends Biochem. Sci. 17(5):177 (1992)]. Trends Biochem. Sci. 16: 338-341 (1991)
  41. Nakamura S., Rodbell M.: Glucagon induces disaggrega­tion of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes polymerization domains. Biochemistry 30: 10957-10965 (1991)
  42. Wang N., Rasenick M.M.: Tubulin-G protein interactions involve microtubule polymerization domains. Biochemistry 30: 10957-10965 (1991)
  43. Stow J.L., de Almeida J.B., Narula N., Holtzman E.J., Ercolani L., Ausiello D.A.: A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J. Cell Biol. 114: 1113-1124 (1991)
  44. Dohlman H.G., Thorner J., Caron M.G., Lefkowitz R.J.: Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60: 653-688 (1991)
  45. Probst W.C., Snyder L.A., Schuster D.I., Brosius J., Sealfon S.C.: Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 11: 1-20 (1992)
  46. Okamoto T., Murayama Y., Hayashi Y., Inagaki M., Ogata E., Nishimoto I.: Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell 67: 723-730 (1991)
  47. Wong Y.H., Conklin B.R., Bourne H.R.: Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science 255: 339-342 (1992)
  48. McClue S.J., Milligan G.: Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera. Mol. Pharmacol. 40: 627-632 (1991)
  49. McFadzean I., Mullaney I., Brown D.A., Milligan G.: Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells. Neuron 3: 177-182 (1989)
  50. Schmidt A., Hescheler J., Offermanns S., Spicher K., Hinsch K.D., Klinz F.J., Codina J., Birnbaumer L., Gause­pohl H., Frank R., et al.: Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihy­dropyridine-sensitive Ca2+currents in an insulin-secreting cell line (RINm5F). J. Biol. Chem. 266: 18025-18033 (1991)
  51. Senogles S.E., Spiegel A.M., Padrell E., Iyengar R., Caron M.G.: Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. J. Biol. Chem. 265: 4507-4514 (1990)
  52. Freissmuth M., Schutz W., Linder M.E.: Interactions of the bovine brain A1-adenosine receptor with recombinant G protein alpha-subunits. Selectivity for rGi alpha-3. J. Biol. Chem. 266: 17778-17783 (1991)
  53. Graber S.G., Figler R.A., Garrison J.C.: Expression and purification of functional G protein alpha subunits using a baculovirus expression system. J. Biol. Chem. 267: 1271-1278 (1992)
  54. Fargin A., Yamamoto K., Cotecchia S., Goldsmith P.K., Spiegel A.M., Lapetina E.G., Caron M.G., Lefkowitz R.J.: Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cell Signal 3: 547-557 (1991)
  55. Cerione R.A., Kroll S., Rajaram R., Unson C., Goldsmith P., Spiegel A.M.: An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function. J. Biol. Chem. 263: 9345-9352 (1988)
  56. Kleuss C., Hescheler J., Ewel C., Rosenthal W., Schultz G., Wittig B.: Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353: 43-48 (1991)
  57. Okamoto T., Katada T., Murayama Y., Ui M., Ogata E., Nishimoto I.: A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell 62: 709-717 (1990)
  58. Murayama Y., Okamoto T., Ogata E., Asano T., Iiri T., Katada T., Ui M., Grubb J.H., Sly W.S., Nishimoto I.: Dis­tinctive regulation of the functional linkage between the hu­man cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate. J. Biol. Chem. 265: 17456-17462 (1990)
  59. Rothenberg P.L., Kahn C.R,: Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins. J. Biol. Chem. 263: 15546-15552 (1988)
  60. Liang M.N., Garrison J.C.: The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. J. Biol. Chem. 266: 13342-13349 (1991)
  61. Teitelbaum I.: The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells. J. Biol. Chem. 265: 4218-4222 (1990)
  62. Altman A., Coggeshall K.M., Mustelin T.: Molecular events mediating T cell activation. Adv. Immunol. 48: 227-360 (1990)
  63. Gukovskaya A.S.: G proteins in T cell signal transduc­tion. Immunol. Lett. 31: 1-9 (1992)
  64. Klaus G.G., Harnett M.M., Rigley K.P.: G-protein regula­tion of polyphosphoinositide breakdown in B cells. Adv. Exp. Med. Biol. 254: 95-100 (1989)
  65. DeFranco A.L., Gold M.R.: Signal transduction via the B cell antigen receptor: involvement of a G protein and regula­tion of signaling. Adv. Exp. Med. Biol. 254: 101-112 (1989)
  66. Hide M., Ali H., Price S.R., Moss J., Beaven M.A.: GTP-binding protein G alpha Z: its down-regulation by dex­amethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells. Mol. Pharmacol. 40: 473-479 (1991)
  67. Strittmatter S.M., Valenzuela D., Kennedy T.E., Neer E.J., Fishman M.C.: Go is a major growth cone protein subject to regulation by GAP-43. Nature 344: 836-841 (1990)
  68. Hynes R.O.: Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25 (1992)
  69. Yatani A., Okabe K., Polakis P., Halenbeck R., McCor­mick F., Brown A.M.: ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+channels. Cell 61: 769-776 (1990)
  70. Thompson N.T., Bonser R.W., Garland L.G.: Receptor-coupled phospholipase D and its inhibition. Trends Pharma­col. Sci. 12: 404-408 (1991)
  71. Traynor-Kaplan A.E., Thompson B.L., Harris A.L., Taylor P., Omann G.M., Sklar L.A.: Transient increase in phos­phatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. J. Biol. Chem. 264: 15668-15673 (1989)
  72. Stracke M.L., Guirguis R., Liotta L.A., Schiffmann E.: Pertussis toxin inhibitsstimulated motility independently of the adenylate cyclase pathway in human melanoma cells. Biochem. Biophys. Res. Commun. 146: 339-345 (1987)
  73. Bengtsson T., Sarndahl E., Stendahl O., Andersson T.: Involvement of GTP-binding proteins in actin polymerization in human neutrophils. Proc. Natl. Acad. Sci. USA 87: 2921-2925 (1990)
  74. Birnbaumer L., Abramowitz J., Brown A.M.: Receptor-effector coupling by G proteins. Biochim. Biophys. Acta 1031: 163-224 (1990)
  75. Katada T., Ui M.: Perfusion of the pancreas isolated from pertussis-sensitized rats: potentiation of insulin secre­tory responses due to beta-adrenergic stimulation. Endocri­nology 101: 1247-1255 (1977)
  76. Vallar L., Spada A., Giannattasio G.: Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330: 566-568 (1987)
  77. Landis C.A., Masters S.B., Spada A., Pace A.M., Bourne H.R., Vallar L.: GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340: 692-696 (1989)
  78. Lyons J., Landis C.A., Harsh G., Vallar L., Grunewald K., Feichtinger H., Duh Q.Y., Clark O.H., Kawasaki E., Bourne H.R., et al.: Two G protein oncogenes in human endocrine tumors. Science 249: 655-659 (1990)
  79. O’Sullivan C., Barton C.M., Staddon S.L., Brown C.L., Lemoine N.R.: Activating point mutations of the gsp onco­gene in human thyroid adenomas. Mol. Carcinog. 4: 345-349 (1991)
  80. McCune D.J.: Osteitis fibrosa cystica. Am. J. Dis. Child. 52:743 (1936)
  81. Weinstein L.S., Shenker A., Gejman P.V., Merino M.J., Friedman E., Spiegel A.M.: Activating mutations of the stimulatory G protein in the McCune-Albright syndrome [see comments]. N. Engl. J. Med. 325: 1688-1695 (1991)
  82. Magovcevic I., Ang S.L., Seidman J.G., Tolman C.J., Neer E.J., Morton C.C.: Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. Genomics 12: 125-129 (1992)
  83. Levine M.A.: Laboratory investigation of disorders of the parathyroid glands. Clin. Endocrinol. Metab. 14: 257-272 (1985)
  84. Patten J.L., Johns D.R., Valle D., Eil C., Gruppuso P.A., Steele G., Smallwood P.M., Levine M.A.: Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright’s hereditary osteodystrophy [see com­ments]. N. Engl. J. Med. 322: 1412-1419 (1990)
  85. Sullivan K.A., Miller R.T., Masters S.B., Beiderman B., Heideman W., Bourne H.R: Identification of receptor contact site involved in receptor-G protein coupling. Nature 330: 758-760 (1987)
  86. Hildebrandt J.D., Day R., Farnsworth C.L., Feig L.A.: A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors. Mol. Cell Biol. 11: 4830-4838 (1991)
  87. Milligan G., Green A.: Agonist control of G-protein levels [see comments]. Trends Pharmacol. Sci. 12: 207-209 (1991)
  88. Lazar-Wesley E., Hadcock J.R., Malbon C.C., Kunos G., Ishac E.J.: Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat. Endocrinology 129: 1116-1118 (1991)
  89. Bilezikian J.P., Loeb J.N.: Mechanisms altered beta-adrenergic responsiveness in the hyperthyroid and hypothy­roid turkey erythrocyte. Life Sci. 30: 663-673 (1982)
  90. Bilezikian J.P., Loeb J.N.: The influence of hyperthyroid­ism and hypothyroidism on alpha- and beta-adrenergic receptor systems and adrenergic responsiveness. Endocr. Rev. 4: 378-388, Fall (1983)
  91. Bilezikian J.P., Loeb J.N., Gammon D.E.: The influence of hyperthyroidism and hypothyroidism on the beta-adrener­gic responsiveness of the turkey erythrocyte. J. Clin. Invest. 63: 184-192 (1979)
  92. Malbon C.C., Gill D.M.: ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats. Biochim. Biophys. Acta 586: 518-527 (1979)
  93. Milligan G., Spiegel A.M., Unson C.G., Saggerson E.D.: Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins. Biochem. J. 247: 223-227 (1987)
  94. Ohisalo J.J., Milligan G.: Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects. Biochem. J. 260: 843-847 (1989)
  95. Kauman A.J.: Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle. Nauynyn Schmiedebergs Arch. Pharmacol. 273: 134 (1972)
  96. Rodan S.B., Rodan G.A.: Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells. Endocrinology 118: 2510-2518 (1986)
  97. Saito N., Guitart X., Hayward M., Tallman J.F, Duman R.S., Nestler E.J.: Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 86: 3906-3910 (1989)
  98. Kirchick H.J., Birnbaumer L.: Effects of estradiol treat­ment on rabbit luteal adenylyl cyclase: loss of luteinizing hormone receptors and attenuation of the regulatory N component activity. Endocrinology 113: 1629-1637 (1983)
  99. Maus M., Homburger V., Bockaert J., Glowinski J., Premont J.: Pretreatment of mouse striatal neurons in primary culture with 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha o,i protein subunits. J. Neurochem. 55: 1244-1251 (1990)
  100. Allard W.J., Vicario P.P., Saperstein R., Slater E.E., Strout H.V.: The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes. Endocrinology 129: 169-175 (1991)
  101. Palmer T.M., Houslay M.D.: Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice., Biochim. Biophys. Acta 1097: 193-204 (1991)
  102. Livingstone C., McLellan A.R., McGregor M.A., Wilson A., Connell J.M., Small M., Milligan G., Paterson K.R., Houslay M.D.: Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects., Biochim Biophys Acta 1096: 2, 127-33, Feb 22, 1991.
  103. Lester BR, McCarthy JB, Sun ZQ, Smith RS, Furcht LT, Spiegel AM, G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones. Cancer Res. 49: 5940-5948 (1989)
  104. Lester B.R., Weinstein L.S., McCarthy J.B., Sun Z.Q., Smith R.S., Furcht L.T.: The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells. Int. J. Cancer 48: 113-120 (1991)
  105. Feldman A.M.: Experimental issues in assessment of G protein function in cardiac disease. Circulation 84: 1852-1861 (1991)
  106. Longabaugh J.P., Vatner D.E., Vatner S.F., Homcy C.J.: Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure-overload left ventricular failure. J. Clin. Invest. 81: 420-424 (1988)
  107. Flavahan N.A., Vanhoutte P.M.: G-proteins and endo­thelial responses. Blood Vessels 27: 218-229 (1990)
  108. Wand G.S., Levine M.A.: Hormonal tolerance to ethanol is associated with decreased expression of the GTP-binding protein, Gs alpha, and adenylyl cyclase activity in ethanol-treated LS mice. Alcohol Clin. Exp. Res. 15: 705-710 (1991)
  109. Hoffman P.L., Tabakoff B.: Ethanol and guanine nu­cleotide binding proteins: a selective interaction. FASEB J. 4: 2612-2622 (1990)
  110. Attali B., Vogel Z.: Long-term opiate exposure leads to reduction of the alpha i-1 subunit of GTP-binding proteins. J. Neurochem. 53: 1636-1639 (1989)
  111. Nestler E.J., Terwilliger R.Z., Walker J.R., Sevarino K.A., Duman R.S.: Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain. J. Neurochem. 55: 1079-1082 (1990)

Online ISSN 1011-6575

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