Τόμος 15 (1997) – Τεύχος 2 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 15 (1997) – Issue 2 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Επιπτώσεις των Γεωργικών Φαρμάκων (κυρίως Εντομοκτόνων) στο Γενετικό Υλικό (DNA)

Effects of Pesticides (mainly Insecti­cides) to the Genetic Material (DNA)

Συγγραφέας – Author

Σ. Ζαχαριουδάκης και Σ.Μ. Πιπεράκης

Ινστιτούτο Βιολογίας, Ε.Κ.Ε.Φ.Ε. Δημόκριτος’, Αγία Παρασκευή, Αθήνα, Ελλάς

S. Zacharioudakis and S. M. Piperakis

Institute of Biology, N.C.S.R. Demokritos’, Agia Paraskevi, Athens, Greece

Παραπομπή – Citation

Ζαχαριουδάκης,Σ., Πιπεράκης,Σ.Μ. : Επιπτώσεις των Γεωργικών Φαρμάκων (κυρίως Εντομοκτόνων) στο Γενετικό Υλικό (DNA) , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 15 :  143-150 (1997)

Zacharioudakis,S., Piperakis,S.M. : Effects of Pesticides (mainly Insecti­cides) to the Genetic Material (DNA), Epitheorese Klin. Farmakol. Farmakokinet. 15 : 143-150 (1997)

Ημερομηνία Δημοσιευσης – Publication Date
20-10-1997
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €)
Digital Type: pdf (15 )
pharmakonpress[at]pharmakonpress[.]gr
Λέξεις κλειδιά – Keywords

Γεωργικά φάρμακα, DNA, βλάβες, επιδιόρθωση, καρκίνος, άνθρωποι

Pesticides, DNA, damage, repair, cancer, humans
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Η χρή­ση των γε­ωρ­γι­κών φαρ­μά­κων εί­ναι ευ­ρύ­τα­τη εξ αι­τί­ας του με­γά­λου α­ριθ­μού των πα­ρα­σι­τι­κών ορ­γα­νι­σμών ζω­ι­κών και φυ­τι­κών. Μί­α κύ­ρια κα­τη­γο­ρί­α γε­ωρ­γι­κών φαρ­μά­κων εί­ναι τα ε­ντο­μο­κτό­να τα οποί­α χρη­σι­μο­ποι­ο­ύ­νται για την κα­τα­πο­λέ­μη­ση των ε­ντό­μων και προ­κα­λούν με­γά­λες κα­τα­στρο­φές στις γε­ωρ­γι­κές καλ­λιέρ­γει­ες. Στην πα­ρού­σα με­λέ­τη γί­νε­ται α­να­σκό­πη­ση των ε­πι­πτώ­σε­ων των ε­ντο­μο­κτό­νων στο γε­νε­τι­κό υ­λι­κό (DNA) των α­νώ­τε­ρων ορ­γα­νι­σμών (θη­λα­στι­κών) με έμ­φα­ση στον άν­θρω­πο. Πε­ριγρά­φε­ται ο ρό­λος που παί­ζει η πα­ρου­σί­α ή μη συ­γκε­κρι­μέ­νων δρα­στι­κών ομά­δων στα μό­ρια των ε­ντο­μο­κτό­νων, ανα­λύ­ο­νται οι ε­πι­πτώ­σεις στο γε­νε­τι­κό υ­λι­κό προ­σβε­βλη­μέ­νων πλη­θυ­σμών και συ­γκρί­νο­νται τα α­πο­τε­λέ­σμα­τα α­πό δια­φο­ρετι­κές με­λέ­τες. Συ­μπε­ρα­σμα­τι­κά, η πο­λύ­χρο­νη χρή­ση ε­ντο­μο­κτό­νων ευρέ­θη να αυ­ξά­νει το πο­σό των γε­νε­τι­κών βλα­βών σε ε­κτε­θει­μέ­νους πλη­θυ­σμούς.

The use of pesticides is widespread due to the large number of parasitic organisms. One major category of pesticides the insecticides is used to treat insects that cause significant damage in crops. In this study a review of the ef­fects of pesticides in the genetic material (DNA) of mammals and in particular the man has been undertaken. The role of certain groups in the in­secticide molecules is been described. The geno­toxic effects in pesticides-exposed polulations are presented comparing results from different stud­ies. In conclusion the long time use of insecticides has found to cause genetic damage in exposed populations.

Αναφορές – References1.
  1. Venkat J.A., Shami S., Davis K., Nayak M., Plimmer J.R., Pfeil R., Nair P.P.: Relative Genotoxic Activities of Pesticides Evaluated by a Modified SOS Microplate Assay. Env. Mol. Mutagenesis 25: 67-76 (1995)
  2. Herrera L.A., Ostrosky-Wegman P., Schiffman D., Chen Q.Y., Ziegler-Skylakakis K., Andrae U.: The insecti­cide bufoprezin induces morphological tranformation and ki­netochore – positive micronuclei in cultured Syrian hamster embryo cells in the absence of detectable DNA damage. Mut. Res. 303: 121-125 (1993)
  3. Bolognesi C., Parrini M., Bonassi S., Ianello G., Salanitto A.: Cytogenetic analysis of a human population occupatinally exposed to pesticides. Mut. Res. 285: 239-249 (1993)
  4. Paldy A., Puskas N., Vinceze K., Handhazi M.: Cyto­genetic studies on rural populations exposed to pesticides. Mut. Res. 187: 127-132 (1987)
  5. Klopman G., Contreras R., Rosenkranz H.S., Waters M.D.: Structure – genotoxic activity relationships of peesti­cides: comparison of the results from several short – term assays. Mut. Res. 147:  343-356  (1985)
  6. Rudek Z., Rozek M.: Induction of micronuclei in tadpoles of Rana temporaria and Xenopus laevis by the pyrethroid Fastac 10 EC. Mut. Res. 298: 25-29 (1992)
  7. Braun R., Schoneich J., Weissflog L., Dedek W. et al: Activity of organophosphorous insecticides in bacterial tests for mutagenicity and DNA repair – Direct alkylation vs. metabolic activation and breakdown. I. Butonate, Vinylbuto­nate, Trichlorfon, Dichlorvos, Demethyl Dichlorvos and De­methyl Vinylbutonate. Chem. Biol. Interactions 39: 339-350 (1982)
  8. Ruiz M.J., Marzin D.: Toxicity of six pesticides by Sal­monella mutagenicity test and SOS chromotest. Mut. Res. 390: 245-255 (1997)
  9. Braun R. Schoneich J., Weissflog L., Dedek W.: Activ­ity of organophosphorous insecticides in bacterial tests for mutagenicity and DNA repair – Direct alkylation versus metabolic activation and breakdown. II. O,O-Dimethyl-O-(1.2,-dibromo-2,2-dichloroethyl)-phosphate and two O-ether derivatives of Trichlorfon. Chem. Biol. Interactions 43: 361-370 (1983)
  10. Ahmed F.E., Hart R. W., Lewis N.J.: Pesticide induced DNA damage and its repair in cultured human cells. Mut. Res. 42: 161-174 (1977)
  11. Creizel A.E.: Phenotypic and cytogenetic studies in self-poisoned patients. Mut. Res. 313: 175-181 (1994)
  12. Scarpato R., Migliore L., Angotzi G., Fedi A., Migli L., Loprieno N.: Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesti­cide exposure. Mut. Res. 367: 73-82 (1996)
  13. Bagchi D., Bagchi M., Hassoun E.A., Stohs S.J.: In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage be selected pesticides. Toxicology 104(1-3): 129-140 (1995)
  14. Matioli F., Robbiano L., Adamo D., Federa R., Martelli A., Brambilla G.: Genotoxic effects of alpha-hexachlorocy­clohexane in primary cultures of rodent and human hepato­cytes. Mutagenesis 11(1): 79-83 (1996) 15. Vasudev, V., Krishnamurthy, N.B.: In vivo cytogenetic analyses of the carbamate pesticides Dithane M-45 and Baygon in mice. Mut. Res.323: 133-135 (1994)
  15. Topakta Υ.M., Rencázo-ullar E.: Chromosomal aberra­tions in cultured human lymphocytes treated with Marshal and its effective ingredient Carbosulfan. Mut. Res. 310: 103-111 (1993)
  16. Amer S., Aboul-ela E.: Cytogenetic effects of pesti­cides. III. Induction of micronuclei in mouse bone marrow by the insecticides cypermethrin and rotenone. Mut. Res. 155: 135-142 (1985)
  17. Tripathy N.K., Majhi B., Dey L., Patnaik K., Das C.C.: Mutagenicity of dimecron studied in 3 mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. Mut. Res. (189): 277-283 (1987)
  18. Cid Gon­zalez M., Matos E.: Chromosomal aberrations in cultured human lympocytes treated with aldicarb, a carbamate pesti­cide. Mut. Res. 191: 99-103 (1987)
  19. Dulout F.N., Pastori M.C., Cid Gonzalez M., Matos E., von Guradze H. N., Maderna C.R., Loria D., Sainz L., Albiano L., Sobel N.: Cytogenetic analysis in plant breed­ers. Mut. Res. 189: 381-386 (1987)
  20. Bhunya S.P., Jena G.B.: Genotoxic potential of the organochlorine lindane (n-BHC): an in vivo study in chicks. Mut. Res. 272: 175-181 (1992)
  21. Bianchi L., Zannoli A., Pizzala R., Stivala L.A., Chie­sara E.: Genotoxicity assay of five pesticides and their mix­tures in Saccharomyces cerevisiae D7. Mut. Res. 321: 203-211 (1994)
  22. Vijayaraghavan M., Nagarajan B.: Mutagenic potential of acute exposure to organophosphorous and organohlorine compounds. Mut. Res.321: 103-111 (1994)
  23. Balaji M., Sasikala K.: Cytogenetic effect of malathion in in vivo culture of human peripheral blood. Mut. Res. 301: 13-17 (1993)
  24. Amer S.M., Aly F.A.E.: Cytogenetic effects of pesti­cides. IV. Cytogenetic effects of the insecticides Gardona and Dursban. Mut. Res. 279: 165-170 (1992)
  25. Tripathy N.K., Patnaik K.K.: Studies on the genotoxic­ity of monocrotophos in somatic and germ-line cells of Dro­sophila. Mut.Res. 279: 23-29 (1992)
  26. Bhunya S.P., Jena G.B.: Studies on the genotoxicity of monocrotophos, an organophosphate insecticide, in the chick in vivo test system. Mut. Res. 292: 231-239 (1993)
  27. Jayashree I. V., Vijayalaxmi K.K., Rahiman M.A.: The genotoxicity of Hinosan, an organophosphorous pesticide in the in vivo mouse. Mut. Res. 322: 77-85 (1994)
  28. Agarwal D.K., Chauchan L.K.S., Gupta S.K., Sunda­raraman V.: Cytogenetic effects of deltamethrin on rat bone marrow. Mut. Res. 311: 133-138 (1994)
  29. Grover I.S., Malhi P.K.: Genotoxic effects of some or­ganophosphorous pesticides. I. Induction of micronuclei in bone marrow cells in rat. Mut. Res. 155: 131-134 (1985)
  30. Malhi P.K., Grover I.S.: Genotoxic effects of some or­ganophosphorous pesticides. II. In vivo chromosomal aber­ration bioassay in bone marrow cells in rat. Mut. Res. 188: 45-51 (1987)
  31. Lin M.F., Wu C.L., Wang T.C.: Pesticide clastogenicity in Chinese hamster ovary cells. Mut. Res. 188: 241-250 (1987)
  32. Cid Gonzalez M., Loria D., Matos E.: Genotoxicity of the pesticide propoxur and itsnitroso derivative, NO-pro­poxur, on human lymphocytes in vitro. Mut. Res. 232: 45-48 (1990)
  33. Patnaik K.K., Tripathy N.K.: Farm-grade chlorpyrifos (Durmet) is genotoxic in somatic and germ-line cells of Dro­sophila. Mut. Res. 279: 15-20 (1992)
  34. Vigfusson N.V., Vyse E.R., Pernsteiner C.A., Daw­son R.J.: In vivo inducttion of sister-chromatide exchange in Umbra limi by the insecticides endrin, chlordane, diazinon and guthion. Mut. Res. 118: 61-68 (1983)
  35. De Ferrari M., Artuso M., Bonassi S., Bonatti S., Cavalieri Z., Pescatore D., Marchini E., Pisano V., Ab­bondandolo A.: Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes. Mut. Res. 260: 105-113 (1991)
  36. Kourakis A., Mouratidou M., Kokkinos G., Barbouti A., Kotsis A., Mourelatos D., Dozi-Vassiliades J.: Fre­quences of chromosomal aberrations in pesticide sprayers working in plasic green houses. Mut. Res. 279: 145-148 (1992)
  37. Rupa D.S., Reddy P.P., Reddi O.S.: Clastogenic effect of pesticides in peripheral lymphocytes of cotton-field work­ers. Mut. Res. 261: 177-180 (1991)
  38. Garett N. E., Frank Stack H., Waters M.D.: Evaluation of the genetic activity profiles of 65 pesticides. Mut. Res. 168: 301-325 (1986)
  39. Piatti E., Marabini L., Chiesara E.: Increase of micro­nucleus frequency in cultured rat hepatocytes treated in vi­tro with benomyl and pirimiphos-methyl separately and in mixture. Mut. Res. 324: 59-64 (1994)
  40. Kappas A., Vachkova R., Lalchev S., Tzoneva M., Markaki M.: Genotoxicity studies on the organophosphorous insecticide chloracetophone. Mut. Res. 240: 203-208 (1990)
  41. Tzoneva M., Kappas A., Georgieva V., Vachkova R., Tziolas V.: On the genotoxity of the pesticides Endodan and Kilacar in 6 different test systems. Mut. Res. 157: 13-22 (1985)
  42. Lebailly P., Godard T., Belhomme P., Sichel F., Gauduchon P.: Analysis of DNA strand breaks induced by pesticides in human cells using the comet assay. Second International Conference on Environmental Mutagens in Hu­man Populations: Prague (August 1995)
  43. Miadokova E., Vlckova V., Duhova V., Trebaticka M., Garajova M., Grolmus J., Podstavkova S., Vlcek D.: Ef­fects of supercypermethrin, a synthetic developmental pyre­throid, on four biological test systems. Mut. Res. 280: 161-168 (1992)
  44. Vlckova V., Miadokova E., Podstavkova S., Vlcek D.: Mutagenic activity of phosmet, the acive component of the organophopshorous insecticide Decemtione EK 20 in Salmonella and Saccharomyces assays. Mut. Res. 302: 153-156 (1993)
  45. Gomez-Arroyo S., Noriega-Aldana N., Osorio A., Galicia F., Ling S., Villalobos-Petrini R.: Sister-chromatid exchange analysis in a rural population of Mexico exposed to pesticides. Mut. Res. 281: 173-179 (1992)
  46. Eto M.: Organophosphorous Pesticides: Organic and Biological Chemistry, p. 387, CRC Press, Cleveland OH, 1974
  47. O’ Brien R.D.: Insecticides: Action and Metabolism, p. 55, p. 164, p.168, p.185, Academic Press, New York and London, 1967

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
Chemical Abstracts

Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
Γλώσσα Πλήρους Κειμένου –
Full Text Language
Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (70 €) –
Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr
Έντυπη Μορφή (70 € + έξοδα αποστολής)
Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr

 

Προσθέστε στους σελιδοδείκτες το μόνιμο σύνδεσμο.

Τα σχόλια είναι απενεργοποιημένα.