Τόμος 5 (1987) – Τεύχος 4 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 5 (1987) – Issue 4 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title
Σκλήρυνση κατά Πλάκας (Ι)
Σύγχρονη Θεώρηση και Αντιμετώπιση της Νόσου

Multiple Sclerosis (I) Current Concepts and Treatment

Συγγραφέας – Author

Ιωάννης Ε. Αναστασόπουλος

Νευρολογική Κλινική Νοσοκομείου “Παμμακάριστος”, Αθήνα

I.E. Anastasopoulos

Neurological Clinic of “Pammakaristos” Hospital, Athens, Greece

Παραπομπή – Citation
Ιωάννης Ε. Αναστασόπουλος,
Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 5(6): 253-259 (1987)
I.E. Anastasopoulos,
Epitheorese Klin. Farmakol. Farmakokinet. 5(6): 253-259 (1987)
Ημερομηνία Δημοσιευσης – Publication Date
Δεκέμβριος 1987  – 1987-12
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (20 €)
Digital Type: pdf (20 €)
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Λέξεις κλειδιά – Keywords
Σκλήρυνση κατά Πλάκας
Multiple Sclerosis
Λοιποί Όροι – Other Terms

Άρθρο Επισκόπησης

Review Article

Περίληψη – Summary
Στην ανασκόπηση αυτή αναπτύσσεται η νόσος σκλήρυνση κατά πλάκας (Σ. Κ. Π., Multiple Sclerosis, M.S.) με ιδιαίτερη έμφαση στο άλυτο ακόμη πρόβλημα της αιτιολογίας της και στο ερώτημα ποιοι παράγοντες έχουν το προβάδισμα, οι εξωγενείς (π.χ. ιοί) ή οι ενδογενείς (π.χ. αντιγόνα του συμπλέγματος μείζονος ιστοσυμβατότητας). Δίνονται αρκετά στοιχεία από την ανοσοβιολογία της νόσου και τη διαταραχή της ισορροπίας των λεμφοκυτταρικών κλώνων, έτσι ώστε να μπορέσει να γίνει κατανοητό το σκεπτικό με το οποίο χορηγείται κάθε φορά ένα θεραπευτικό μέσο και να αξιολογηθούν τα αποτελέσματά του. Εκτίθενται ακόμη οι δυσκολίες που παρουσιάζουν στην πράξη οι κλινικές φαρμακολογικές μελέτες, λόγω της ποικιλομορφίας της νόσου, καθώς και το θέμα της επιλογής των ασθενών, του χρόνου παρακολούθησής τους και της αξιολόγησης των αποτελεσμάτων με αντικειμενικά κριτήρια. Τα χορηγούμενα θεραπευτικά μέσα εξετάζονται το καθένα χωριστά, ανάλογα αν προκαλούν καταστολή ή ενίσχυση του αυτορυθμιζόμενου ανοσοβιολογικού μηχανισμού. Τέλος, συμπεραίνεται πως τη μεγαλύτερη αποτελεσματικότητα, με τις λιγότερες παρενέργειες, έχουν επιτύχει φαρμακευτικά μέσα που δρουν ανοσοκατασταλτικά.

 

Observations from a considerable number of uncontrolled and controlled trials indicate that treatment with immunosuppressive or immunostimulatory agents can alter the clinical course of M.S. Better progress has been made in the field of immunosuppressive therapy. Much effort is concentrated on the detection of a multiple sclerosis susceptibility gene. Should this research be successfulf then antibodies directed against distinct MHC products may supress immune responses which produce demyelination. Both immunosuppresive and immunostimulatorytreatments have been found to be most effective in the early stages of M.S. It is therefore recommended that new studies should distinguish patients in early stages from those in advanced. Finally, since ΗLΑ antigens seems to influence sensitivity to therapeutic agents the stratification of patients according to their HLA type may further increase treatment efficacy.
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