Τόμος 2 (1984) – Τεύχος 3 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 2 (1984) – Issue 3 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Anticoagulant Drugs

M. N. SECHAS

^{Β’ Χειρουργική Προπαιδευτική Κλινική, Πανεπιστήμιο Αθηνών}

2: 179-189 (1984)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

2: 179-189 (1984)

Anticoagulant Drugs

In the past forty years the anticoagulants have acquired unprecedented popularity, although the exact mechanism, by which they interfere with blood coagulation, has not been as yet fully elucidated. Heparin continues to remain the drug of choice for practically every anticoagulation regime, espe­cially when an instant antithrombotic effect is required. The introduction of the calcium salt, allowing subcutaneous administration, haw been a great progress. The coumarin derivates are used for long-term anticoagulation treat­ment with excellent results and minimal com­plications. The antiplatelet agents and parti­cularly aspirin and dipyridamole, have been studied extensively both clinically and experi­mentally. While it does not seem that they may play a significant role in the treatment of thrombosis, they might contribute to the pre­vention of several forms of it. The fibrinolytic agents are theoretically the ideal anticoagu­lants. However, their serious complications and their high cost, have limited their use to a number of selected serious thrombotic cases.

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