Τόμος 4 (1986) – Τεύχος 1 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 4 (1986) – Issue 1 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

^{Πανεπιστήμιο Τουρίνου, Ιταλία*, Επιστημονικό Τμήμα Laboratoires OM, SA, Γενεύη, Ελβετία**}

3: 253-258 (1986)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 253-258 (1986)

Platelet-Activating Factor, PAF

Platelet activating factor (PAF) is a newly discovered mediator which is libera­ted by stimulated cells like the platelets, the neutrophils and the endothelial cells. PAF e­xerts a variety of biological effects including: a potent increase in platelet aggregation, vascu­lar permeability, cell migration and broncho­spasm. Its chemical structure, biosynthesis, ori­gin and pharmacological actions are discussed. Research studies suggest that PAF may be implicated in the pathogenesis of diabetic mi­croangiopathy. So, agents that interfere with PAF-mediated effects may be of potential inte­rest. Among other drugs, calcium dobesilate (Doxium) a vascular protector with antiplatelet effects, was also found to strikingly inhibit PAF production in a dose and time-dependent way. The use of this drug as a PAF antagonist may present a new therapeutic approach.

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