Τόμος 41 (2023) – Τεύχος 1 – Άρθρο 8 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 41 (2023) – Issue 1 – Article 8 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Ατοπική δερματίτιδα και νερό: Υπάρχει το βέλτιστο επίπεδο πρόσληψης νερού για τη βελτίωση του ατοπικού δέρματος;

Atopic Dermatitis and Water: Is There an Optimum Water Intake Level for Improving Atopic Skin?

Συγγραφέας – Author

Νικόλαος Δουλαδίρης, Ευστράτιος Βακιρλής, Αιμιλία Βασιλοπούλου

Αλλεργιολογική Μονάδα, 2η Παιδιατρική Κλινική, Πανεπιστήμιο Αθηνών, 11527 Αθήνα, Ελλάδα
Α’ Τμήμα Δερματολογίας και Αφροδισιολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, 54124 Θεσσαλονίκη, Ελλάδα
Τμήμα Επιστημών Διατροφής και Διαιτολογίας, Διεθνές Πανεπιστήμιο, 57400 Θεσσαλονίκη, Ελλάδα

Nikolaos Douladiris, Efstratios Vakirlis, Emilia Vassilopoulou

Allergy Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, 11527 Athens, Greece
First Department of Dermatology and Venereology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece

Παραπομπή – Citation

N. Douladiris, E. Vakirlis, E. Vassilopoulou. Atopic Dermatitis and Water: Is There an Optimum Water Intake Level for Improving Atopic Skin?  Epitheorese Klin. Farmakol. Farmakokinet. 2023, 41, 1, 55-71

Ημερομηνία Δημοσιευσης – Publication Date
10-03-2023
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Λέξεις κλειδιά – Keywords
ατοπική δερματίτιδα, ατοπικό δέρμα, στοματική ενυδάτωση, νερό

atopic dermatitis, atopic skin, oral hydration, water

Λοιποί Όροι – Other Terms

Μελέτη
Αrticle

Περίληψη – Summary
Το νερό είναι ένα ζωτικής σημασίας θρεπτικό συστατικό με αναρίθμητες λειτουργίες για κάθε ζωντανό κύτταρο. Οι λειτουργίες του ανθρώπινου δέρματος περιλαμβάνουν προστασία από την αφυδάτωση του σώματος. Η ατοπική δερματίτιδα (AD) είναι χρόνια κνησμώδης φλεγμονώδης δερματική νόσος που εκδηλώνεται με ξηροδερμία, ερυθηματώδεις και εκζεματώδεις αλλοιώσεις και λειχηνοποίηση. Αυτό το άρθρο συζητά το ερώτημα εάν η πρόσθετη πρόσληψη νερού σε παιδιά με ατοπική δερματίτιδα επηρεάζει την ενυδάτωση του δέρματος και τη λειτουργία του δερματικού φραγμού. Μεταξύ των μεθόδων που χρησιμοποιούνται για τη θεραπεία του ξηρού δέρματος,τα προϊόντα τοπικής χρήσης είναι η θεραπεία πρώτης γραμμής, που αποσκοπεί στη βελτίωση της ενυδάτωσης και τη λειτουργία δερματικού φραγμού. Η αποτελεσματικότητα της επαρκούς πρόσληψης νερού ως μέτρο για την αντιμετώπιση της ξηροδερμίας είναι ακόμη υπο συζήτηση. Η κανονική ενυδάτωση του δέρματος αυξάνεται με τη διαιτητική πρόσληψη νερού, ιδιαίτερα σε αυτούς που είχαν χαμηλότερη κατανάλωση νερού. Η ξηρότητα του δέρματος στην ατοπική δερματίτιδα είναι καθοριστική για τον κύκλο του κνησμού και της φλεγμονής, συμβάλλοντας στη μείωση του φραγμού και στην επιδείνωση της σοβαρότητας και των εξάρσεων της νόσου. Ορισμένα μαλακτικά παρέχουν σημαντική ενυδάτωση στο δέρμα με ατοπική δερματίτιδα, με ανακούφιση από την ξηρότητα και μείωση της βλάβης του φραγμού, της σοβαρότητας της νόσου και τις εξάρσεις. Απαιτούνται περαιτέρω έρευνες για την αξιολόγηση των βέλτιστων επιπέδων πρόσληψης νερού σε παιδιά με ετοπική δερματίτιδα, καθώς σημαντικά ερωτήματα παραμένουν αναπάντητα, δηλαδή, παρέχει η στοματική ενυδάτωση ανακούφιση από την ξηρότητα του δέρματος και μειώνει την εξασθένιση του φραγμού, τη σοβαρότητα της νόσου και τις εξάρσεις; Υπάρχει καθόλου πρόσθετο όφελος από τη χρήση μεταλλικού ή νερού ιαματικής πηγής; Υπάρχει ανάγκη ειδικής μελέτης για τους περιορισμούς της πρόσληψης υγρών/νερού σε παιδιά με ατοπική δερματίτιδα και τροφική αλλεργία;Water is a vital nutrient with innumerable functions for every living cell. The functions of human skin include protection against dehydration of the body. Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease that presents with dry skin, erythematous and eczematous lesions, and lichenification. This paper discusses the question of whether extra water intake in children with AD affects skin hydration and the skin barrier function. Among the methods used to treat dry skin, topical leave-on products are the first-line treatment, intended to improve hydration and the skin barrier function. The effectiveness of adequate water intake as a measure to treat dry skin is still under debate. Normal skin hydration increases with dietary water intake, particularly in those with prior lower water consumption. Skin dryness in AD is instrumental to the itch and inflammation cycle, contributing to barrier impairment and aggravating disease severity and flares. Certain emollients provide significant hydration to AD skin, with relief of dryness and reduction in barrier impairment, disease severity, and flares. Further investigations are needed to evaluate the optimum water intake levels in children with AD, as important questions remain unanswered, namely, does oral hydration provide relief of skin dryness and reduce barrier impairment, disease severity, and flares; is there any additional benefit from using mineral or thermal spring water; or is there a need to specifically study the fluid/water intake in children with AD and food allergy (FA) restrictions?
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