Τόμος 42 (2024) – Τεύχος 2-3 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 2-3 – Article 1 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

Background: The papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, while Hashimoto’s thyroiditis (HT) is the most common inflam¬matory thyroid disease. The coincidental coexistence or the possible predisposing, protective or aggravating role of HT in the development of PTC have been repeatedly examined. Aim: The aim of the present study was to eval¬uate histopathological and clinical data obtained from pa¬tients with HT, PTC, and PTC+HT so as to investigate the possible association of HT with PTC. Methodology: The study’s cohort consisted of 114 patients (67 PTC, 29 PTC+HT, and 18 HT patients). A full record of their clini-copathological and clinical laboratory data was followed by extensive statistical analysis in order to reveal possi¬ble correlations between the existence of each disease and various clinicopathological parameters. The study was conducted from 2019 to 2023 at the Hippokration General Hospital of Athens (Greece). Results: A signifi¬cant increase in the levels of thyroid-stimulating hormone (TSH; p=0.031), anti-thyroglobulin antibodies (Anti-Tg; p<0.001), and anti-thyroid peroxidase antibodies (Anti-TPO; p<0.001) was observed in the PTC+HT group. These patients also have smaller tumors (p=0.015) and a younger age of disease onset (p<0.001), while the ma¬jority of PTC+HT patients were women (p=0.023) and had infiltrated lymph nodes (p=0.002). Furthermore, the majority of patients with infiltration of the capsule be¬longed to the PTC+HT group (57.1%; p=0.032). Conclu¬sion: PTC+HT represents a less aggressive clinical state, as good prognostic markers of PTC correlate with the presence of HT. In PTC+HT patients, the PTC tends to have early onset age and the primary tumor is often small, while the majority of PTC+HT patients are women Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 8 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 8 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

The phenomenon of longevity and healthy aging as well as the factors that can slow down or even prevent the appearance of pathological conditions related to aging is a subject of interest in modern biology and medical research. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 7 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 7 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

Open Access Review Πρόσφατες νομοθετικές ρυθμίσεις και ανερχόμενες τάσεις στην Κοσμητολογία- Recent legislation and emerging trends in Cosmetology Αnna Giannakoudaki1 1Department of Nutritional Sciences and Dietetics International Hellenic University, Sindos 57400, Thessaloniki *Corresponding author 1Department of Nutritional Sciences and Dietetics International Hellenic University, Sindos 57400, Thessaloniki E-mail: annagianna@live.com Download PDF … Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 6 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

Cosmetic products whose ingredients and especially the active agents have a natural origin, are characterized as natural. Natural cosmetics may have plant (extracts, essential oils, active plant ingredients, etc.) animal, marine or mineral ingredients with the least and safest possible processing. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 5 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

With the increase in interest for natural innovative skin care products, an effort was made in our laboratory to study the beneficial effects of cannabinoids and prebiotics/probiotics on the skin. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 4 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

he aim of the present experimental study is the incorporation of an extract of the Porphyra Umbilicalis seaweed, which contains mycosporin derivatives (MAAs) in a sunscreen formulation, in combination with organic filters, in order to study its influence on the SPF and UVA PF. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 3 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

Oxidative stress is quite a significant form of attack on the skin as it is considered one of the most important factors that causes skin aging. The article attempts to understand oxidative stress in the skin through in vitro studies targeting various biochemical pathways. In addition, cosmetic ingredients are described with the aim of both preventing oxidative stress on the skin as well as maintaining and enhancing the essential biological functions of the skin. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

A balanced microbiome protects against external environmental factors, strengthens the skin’s defenses and slows the appearance of the signs of skin aging. In recent years, alternative treatments have been sought to treat various skin problems, through modification or supplementation of the microbiome, using prebiotics and probiotics. Continue reading

Τόμος 42 (2024) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 42 (2024) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes-Greek Edition

The phenomenon of longevity and healthy aging as well as the factors that can slow down or even prevent the appearance of pathological conditions related to aging is a subject of interest in modern biology and medical research. In this context, a series of clinical and biochemical indicators are recorded and evaluated, as well as a wide variety of cellular aging biomarkers that include molecular signals and biomolecules at the proteomic, metabolomic, genomic and epigenetic level. Continue reading