Τίτλος – Title
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Μoριακοί Μηχανισμοί των Φαρμάκων που Χρησιμοποιούνται στη Χρόνια Καρδιακή Ανεπάρκεια Μolecular Mechanisms of the Drugs that are used in the Treatment of the Chronic Heart Failure |
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Συγγραφέας – Author
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Β. Α. Κόκκας Α΄ Εργαστηριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Θεσσαλονίκη, Ελλάς Β.Α. Κokkas 1st Departement of Pharmacology, Medical School, Aristotle University, Thessaloniki, Hellas |
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Παραπομπή – Citation
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Κόκκας,Β.Α. : Μoριακοί Μηχανισμοί των Φαρμάκων που Χρησιμοποιούνται στη Χρόνια Καρδιακή Ανεπάρκεια, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 28: 171-178 (2010) Κokkas,B.A. : Μolecular Mechanisms of the Drugs that are used in the Treatment of the Chronic Heart Failure, Epitheorese Klin. Farmakol. Farmakokinet. 28: 171-178 (2010) |
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Ημερομηνία Δημοσιευσης – Publication Date
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1 Δεκεμβρίου 2010 – 2010-12-01
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Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Καρδιακή ανεπάρκεια, β-αδρενεργικοί αποκλειστές, αΜΕΑ, αποκλειστές ΑΤ1-υποδοχέων, σπιρολακτόνη, διουρητικά αγκύλης, θειαζιδικά διουρητικά, δακτυλίτιδα
Heart failure, b-blockers, ACE inhibitors, spirolactone, thiazine diouretics, loop diuretics, digitalis derivatives
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– The molecular mechanisms of the drugs that are used in the treatment of the chronic heart failure are discussed in this article. Drugs, like β-adrenergic blockers, try to decrease the cardiac rate and the arterial pressure and act by inhibiting 7-TM receptors coupled to Gs-proteins. Angiotensin II hypertensive actions can be inhibiting by two ways. ACE inhibitors work on an enzyme level, while AT1-blockers act by inhibiting 7-TM receptors coupled to Gq-proteins too. Diuretics are administered in order to decrease the extracellular water volume. Loop diuretics and thiazide diuretics inhibit ion carriers, while spirolactone inhibits the nuclear receptor of aldosterone. Digitalis derivatives inhibit ion pumps in order to exert a positive inotropic effect. |
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Αναφορές – References
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