Τόμος 28 (2010) – Τεύχος 2 – Άρθρο 13 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 28 (2010) – Issue 2 – Article 13 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Θεραπεία Καρδιακής Ανεπάρκειας

Pharmaceutical treatment of heart failure

Συγγραφέας – Author

Ιωάννης Κανονίδης

Αναπληρωτής Καθηγητής Καρδιολογίας, Β΄ Καρδιολογική Κλινική, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς

Ioannis Kanonidis

Associate Professor of Cardiology, 2nd Department of Cardiology, Medical School, Aristotle University, Thessaloniki-Greece

Παραπομπή – Citation

Κανονίδης,Ι. : Θεραπεία Καρδιακής Ανεπάρκειας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 28: 179-183 (2010)

Kanonidis,I. : Pharmaceutical treatment of heart failure, Epitheorese Klin. Farmakol. Farmakokinet. 28: 179-183 (2010)

Ημερομηνία Δημοσιευσης – Publication Date
1 Δεκεμβρίου 2010 – 2010-12-01
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €)
Digital Type: pdf (15 €)
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Λέξεις κλειδιά – Keywords
Heart failure, ACE inhibitors, Inotropes, beta blockers
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Pharmaceutical treatment of heart failure includes a variety of drug classes which a variety of drug classes which defer significally in their pharmacological properties and action. Drugs should be divided in two categories according to whether they improve only symptoms or in addition improve also survival. The first category includes diuretics and digoxin which improves symptoms but has no beneficial effect on survival. ACE inhibitors and AT1 blockers are drugs which improve both symptoms and survival given alone as monotherapy or in combination. Beta blockers are the recently discovered class which bears the most favorable impact on survival inducing in some cases severe heart remodeling. Inotropes can be used in cases of acute deconpensation of chronic heart failure but their chronic oral use has proved to be detrimental regarding survival although they improve functional capacity.

Αναφορές – References
1. Digitalis Investigation Group: The effect of digoxin on mortality and morbidity in patients with heart failure. N. Engl. J. Med. 336: 525-533 (1977)

2. Packer M., Carver J.R., Rodeheffer R.J., et al.: Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N. Engl. J. Med. 325: 1468-1475 (1991)

3. Cohn J.N., Johnson G., Ziesche S., et al.: A comparison of enalapril with hydralazine – isosorbide dinitrate in the treatment of chronic congestive heart failure. N. Engl. J. Med. 325: 303-310 (1991)

4. The CONSENSUS Trial Study Group: Effects of enalapril on mortality in severe congestive hear failure. Results of the Co-operative North Scandinavian Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 316: 1429-1435 (1987)

5. The SOLVD Investigators: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 325: 293-302 (1991)

6. The SOLVD Investigators: Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N. Engl. J. Med. 327: 685-691(1992)

7. Granger C.B., McMurray J.J., Yusuf S., et al.: Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 362: 772-776 (2003)

8. Pfeffer M.A., Swedberg K., Granger C.B., et al.: Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 362: 759-766 (2003)

9. Pitt B., Zannad F., Remme W.J. et al.: The effect of spiro-nolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N. Engl. J. Med. 341: 709-717 (1999)

10. Pitt B., Remme W., Zannad F., et al.: Elperenone, a selec-tive aldosterone blocker, in patients with left ventricular dys-function after myocardial infarction. N. Engl. J. Med. 348: 1309-1321 (2003)

11. Cohn J.N.: Beta-blockers in heart failure. Eur. Heart J. 19(Suppl. F): F52-F55 (1998)

12. Poole-Wilson P.A., Swedberg K., Cleland J.G., et al.: Com-parison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET`): randomized controlled trial. Lancet 362: 7-13 (2003)

13. Clenland J.G.F., Poole-Wilson P.A.: ACE inhibitors for heart failure: A question of dose. Br. Heart J. 72: S106-10 (1994)

14. Clenland J.G.F., Poole-Wilson P.A.: The Clinical course of heart failure and its modification by the ACE inhibitors: Insights from recent clinical trials. Eur. Heart J. 72: S125-130 (1994)

15. Australia/New Zealand Heart Failure Research Collaborative Group: Randomized, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease. Lancet 349: 375-80 (1997)

16. Waagstein F., Caidahl K., Wallentin I., Bergh C., Hjalmarson A.: Long-term b-blockade in dilated cardiomyopathy. Cir-culation 80: 551-563 (1989)

17. Waagstein F., Bristow M.R., Swedberg K., et al.: For the Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Lancet 342: 1441-1446 (1993)

18. Olsen S.L., Gilbert E.M., Renlund D.G., et al.: Carvedilol improves left ventricular function and symptoms in chronic heart failure: A double-blind study. J. Am. Coll. Cardiol. 25: 1225-1231 (1995)

19. Woodley S.L., Gilbert E.M., Anderson J.L., et al.: b-Blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy. Circulation 84: 2426-2441 (1991)

20. CIBIS Investigators and Comittees: A randomized trial of b-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation 90: 1765-1773 (1994)

21. Ambrosioni E., Borghi C., Magnani B.: The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. N. Engl. J. Med. 332: 80-85 (1995)

22. The AIRE Study Group: Effect of ramipril on mortality and morbidity of survivors of the acute myocardial infarction with clinical evidence of heart failure. Lancet 342: 821-828 (1993)

23. Kelly R.A., Smith T.W.: Digoxin in heart failure: Implications of recent trial. J. Am. Coll. Cardiol. 22(Suppl A): 107A-112A (1993)

24. Arnold S.B., Byrd R.C., Meister W., et al.: Long-term digitalis therapy improves left ventricular function in heart failure. N. Engl. J. Med. 303: 1443-1448 (1980)

25. Just H., Drexler H., Taylor S.H., et al.: Captopril versus digoxin in patients with coronary artery disease and mild heart failure. A prospective, double-blind, placebo controlled multicentre study. The CADS Study Group. Herz 18(Suppl 1): 436-443 (1993)

26. Gilbert E.M., Abraham W.T., Olsen S., et al.: Comparative hemodynamic left ventricular functional and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation 94: 2817-25 (1996)

27. Packer M., Bristow M.R., Cohn J.N., et al.: Effect of carvedilol on morbidity and mortality in chronic heart failure. US Carvedilol Heart Failure Study Group. N. Engl. J. Med. 334: 1349-1355 (1996)

 

 

Online ISSN 1011-6575

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Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
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