Τίτλος – Title
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Θεραπεία Καρδιακής Ανεπάρκειας Pharmaceutical treatment of heart failure |
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Συγγραφέας – Author
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Ιωάννης Κανονίδης Αναπληρωτής Καθηγητής Καρδιολογίας, Β΄ Καρδιολογική Κλινική, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς Ioannis Kanonidis Associate Professor of Cardiology, 2nd Department of Cardiology, Medical School, Aristotle University, Thessaloniki-Greece |
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Παραπομπή – Citation
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Κανονίδης,Ι. : Θεραπεία Καρδιακής Ανεπάρκειας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 28: 179-183 (2010) Kanonidis,I. : Pharmaceutical treatment of heart failure, Epitheorese Klin. Farmakol. Farmakokinet. 28: 179-183 (2010) |
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Ημερομηνία Δημοσιευσης – Publication Date
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1 Δεκεμβρίου 2010 – 2010-12-01
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Παραγγελία – Αγορά –
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Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords
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Heart failure, ACE inhibitors, Inotropes, beta blockers
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– Pharmaceutical treatment of heart failure includes a variety of drug classes which a variety of drug classes which defer significally in their pharmacological properties and action. Drugs should be divided in two categories according to whether they improve only symptoms or in addition improve also survival. The first category includes diuretics and digoxin which improves symptoms but has no beneficial effect on survival. ACE inhibitors and AT1 blockers are drugs which improve both symptoms and survival given alone as monotherapy or in combination. Beta blockers are the recently discovered class which bears the most favorable impact on survival inducing in some cases severe heart remodeling. Inotropes can be used in cases of acute deconpensation of chronic heart failure but their chronic oral use has proved to be detrimental regarding survival although they improve functional capacity. |
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Αναφορές – References
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F): F52-F55 (1998) 12. Poole-Wilson P.A., Swedberg K., Cleland J.G., et al.: Com-parison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET`): randomized controlled trial. Lancet 362: 7-13 (2003) 13. Clenland J.G.F., Poole-Wilson P.A.: ACE inhibitors for heart failure: A question of dose. Br. Heart J. 72: S106-10 (1994) 14. Clenland J.G.F., Poole-Wilson P.A.: The Clinical course of heart failure and its modification by the ACE inhibitors: Insights from recent clinical trials. Eur. Heart J. 72: S125-130 (1994) 15. Australia/New Zealand Heart Failure Research Collaborative Group: Randomized, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease. Lancet 349: 375-80 (1997) 16. Waagstein F., Caidahl K., Wallentin I., Bergh C., Hjalmarson A.: Long-term b-blockade in dilated cardiomyopathy. Cir-culation 80: 551-563 (1989) 17. Waagstein F., Bristow M.R., Swedberg K., et al.: For the Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Lancet 342: 1441-1446 (1993) 18. Olsen S.L., Gilbert E.M., Renlund D.G., et al.: Carvedilol improves left ventricular function and symptoms in chronic heart failure: A double-blind study. J. Am. Coll. Cardiol. 25: 1225-1231 (1995) 19. Woodley S.L., Gilbert E.M., Anderson J.L., et al.: b-Blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy. Circulation 84: 2426-2441 (1991) 20. CIBIS Investigators and Comittees: A randomized trial of b-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation 90: 1765-1773 (1994) 21. Ambrosioni E., Borghi C., Magnani B.: The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. N. Engl. J. Med. 332: 80-85 (1995) 22. The AIRE Study Group: Effect of ramipril on mortality and morbidity of survivors of the acute myocardial infarction with clinical evidence of heart failure. Lancet 342: 821-828 (1993) 23. Kelly R.A., Smith T.W.: Digoxin in heart failure: Implications of recent trial. J. Am. Coll. Cardiol. 22(Suppl A): 107A-112A (1993) 24. Arnold S.B., Byrd R.C., Meister W., et al.: Long-term digitalis therapy improves left ventricular function in heart failure. N. Engl. J. Med. 303: 1443-1448 (1980) 25. Just H., Drexler H., Taylor S.H., et al.: Captopril versus digoxin in patients with coronary artery disease and mild heart failure. A prospective, double-blind, placebo controlled multicentre study. The CADS Study Group. Herz 18(Suppl 1): 436-443 (1993) 26. Gilbert E.M., Abraham W.T., Olsen S., et al.: Comparative hemodynamic left ventricular functional and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. 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Ελληνικά – Greek
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