Τόμος 27 (2009) – Τεύχος 3 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 3– Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

O Αγγειακός Ενδοθηλιακός Παράγοντας (VEGF) και ο Ρόλος του στη Διαβητική Νεφροπάθεια

Vascular Endothelial Growth Factor (VEGF) and its Role in Diabetic Nephropathy

Συγγραφέας – Author

Κωνσταντίνος Τόμος, Μαρία Μυρωνίδου–Τζουβελέκη

Α΄ Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς

Constantinos Tomos, Maria Mironidou-Tzouveleki

Department of Pharmacology, Medical School, Aristotle University, Thessaloniki, Hellas

Παραπομπή – Citation

Τόμος,Κ., Μυρωνίδου–Τζουβελέκη,Μ. : O Αγγειακός Ενδοθηλιακός Παράγοντας (VEGF) και ο Ρόλος του στη Διαβητική Νεφροπάθεια, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 275-282 (2009)

Tomos,C., Mironidou-Tzouveleki,M. : Vascular Endothelial Growth Factor (VEGF) and its Role in Diabetic Nephropathy, Epitheorese Klin. Farmakol. Farmakokinet. 27: 275-282 (2009)

Ημερομηνία Δημοσιευσης – Publication Date
25 Οκτωβρίου 2009 – 2009-10-25
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords
Αγγειακός ενδοθηλιακός παράγοντας (VEGF), διαβητική νεφροπάθεια
Vascular endothelial growth factor (VEGF), diabetic nephropathy
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Τα τελευταία χρόνια παρατηρείται ιδιατερα αυξημένο ενδιαφέρον στην παγκόσμια βιβλιογραφία για το ρόλο του αγγειακού ενδοθηλιακού παράγοντα (VEGF) στη διαβητική νεφροπάθεια. Η αυστηρή ρύθμιση των επιπέδων του VEGF στο νεφρό είναι απαραίτητη για την ανάπτυξη και διατήρηση του σπειραματικού διηθητικού φραγμού. Ο VEGF, εκκρινόμενος κύρια από τα ποδοκύτταρα και όντας παράγοντας αγγειογένεσης και διαπερατότητας, θεωρείται ότι συμμετέχει στην παθογένεια της διαβητικής πρωτεϊνουρίας. Στα πειραματικά μοντέλα διαβήτη φαίνεται να αυξάνεται σημαντικά η έκφρασή του, προκαλώντας ορισμένες επιπλοκές του διαβήτη, ενώ η αναστολή του βελτιώνει κάποιες από αυτές. Αντίθετα, στον άνθρωπο κάποιοι συγγραφείς βρίσκουν θετική, ενώ άλλοι αρνητική ή καθόλου συσχέτιση του VEGF με τη διαβητική νεφροπάθεια.

In recent years, there is an increased interest in world literature concerning the role of vascular endothelial growth factor (VEGF) in diabetic nephropathy. VEGF is an angiogenesis and a permeability factor, which is expressed in the kidney mainly in podocytes. A tight regulation of VEGF expression level is required for the development and maintenance of the glomeroular filtration barrier. VEGF is considered to participate in the pathogenesis of diabetic proteinuria. In experimental murine models of diabetes, the expression of VEGF appears to increase significantly, causing some complications of diabetes. The inhibition of overexpression of this protein ameliorates some of the complications. Instead, some authors find a positive, negative or no correlation of VEGF in human diabetic nephropathy.

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