Τόμος 1 (1983) – Τεύχος 3 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 3 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Mechanisms of Chemical Carcinogenesis

Κέντρο Βιολογικών Ερευνών, Εθνικό Ίδρυμα Ερευνών

Sotiris A. Kyrtopoulos

Biological Research Centre, National Hellenic Research Foundation, 48, Vas. Constantinou Ave., Athens, Greece

Kyrtopoulos, S.A.: Mechanisms of Chemical Carcinogenesis, Epitheorese Klin. Farmakol. Farmakokinet. 3: 164-177 (1983)

Chemical substances, carcinogenic effects,DNA

2.         Hieger, I.: The spectra of cancer-producing tars and oils of related substances. Biochem. J. 24: 505 (1930)

3.         Doll, R.: Strategy for the detection of cancer hazards in man. Nature 265: 589 (1977)

4.         Higginson, J.: Present trends in cancer epidemiology. Can. Cancer Conf. 8: 40 (1969)

5.         International Agency for Research in Cancer Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Volumes 1-29, Lyon

6.         Chemicals and industrial processes associated with cancer in humans. IARC Monographs on the evaluation of the carcinogenic risk of chemical to humans. Supplement I, Lyon, 1979

7.         Magee, P.N., Montesano, R., Preussman, R.: N-IMitroso compounds and related Carcinogens. In: Chemical Carcinogens. (C.E. Searle ed.) American Chemical Society Monograph No. 173, p. 491. Washington D.C. 1976

8.         Miller, E.C., Miller, J.A.: The presence and significance of bound aminoazo dyes im the livers of rats fed p-dimethy- laminoazobenzene. Cancer R es. 7: 468 (1947)

9.         Heidelberger, C.: Studies on the molecular mechanism of hydrocarbon carcinogenesis. J. Cell. Comp. Physiol. 64 (Suppi. 1): 129 (1964)

10.       Heideiberger, C: Chemical carcinogenesis. Ann. Rev. Biochem. 44: 79 (1975)

11.        Weisburger, E.K., Weisburger, J.H.: Chemistry, carcinogenisity and metabolism of fluorenamine and related compounds. Adv. Cancer Res. 5: 331 (1958)

12.       Magee, P.N., Farber, E.: Toxic liver injury and carcinogenesis. Méthylation of rat-liver nucleic acids by dimethylnitrosamine in vivo. Biochem. J. 83: 114 (1962)

13.       Miller, E.C.: Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res. 38: 1479 (1978)

14.       Miller, J.A.: Carcinogenesis by chemicals. An overview. Cancer Res. 30: 559 (1970)

15.       Sims, P.: Metabolic activation of carcinogens, Brit. Med. Boll. 36: 1 1 (1980)

16.       Vaught, J., Bresnick, Ë.: Binding of polycyclic hydrocarbons to nuclear components in vitro. Biophys. Biochem. Res. Commun. 69: 587 (1976)

1 7. Kawajiri, K„ Yonekawa, H., Hara, E., Tagashira, Y.: Activation of 2-acetylaminofluorene in the nuclei of rat liver. Cancer Res. 39: 1089 (1979)

18.       Brookes, P.: The binding to mouse skin DMA of benzolalpyrene, its 7,8-diol and 7,8-diol 9, 10-epoxides in relation to the tumourigenicity of these species. Cancer Lett. 6:285 (1979)

19.       Swann, P.E., Kyrtopoulos, S.A.: Reaction with DNA and DNA-repatrin chemical carcinogenesis. In: Mechanisms of toxicity and hazard evaluation (B. Holmstedt, R. Lauwerys, M. Mercier, M. Roberfroid eds), p. 219, Elsevier-North Holland Biomedical Press, 1980

20.      Lin, J.-K., Miller, J.A., Miller, E.C.: 2,3-Dihydro-2- (guan-7-yl)-3-hydroxyaflatoxin Bv a major acid hydrolysis product of aflatoxin B, -DNA or -rRNA adducts in hepatic microsome-mediated reactions and in rat liver in vivo. Cancer Res. 37: 4430(1977)

21.       Pegg, A.E.: Metabolism of dimethylnitrosamine. In: Molecular and cellular aspects of carcinogen screening tests (R. Monetsano, H. Bartsch, L. Tomatis eds.’ IARC Scientific Publications No. 27, p. 3. IARC, Lyon, 1980

22.       Nicoll, J.W., Swann, P.F., Pegg, A.E.: The accumulation of O6 -methylguanine in the liver and kidney of rats treated with dimethylnitrosamine for a short or a long period. Chem. -Biol. Interac. 16: 301 (1977)

23.       Hodgson, R., Wiessler, M., Kleihues, P.: Preferential méthylation of target organ DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine. Carcinogenesis 1: 860 (1980)

24.       Okada, M„ Hashimoto, M.: Carcinogenic effect of N-nitrosoamines related to butyl-(4-hydroxybutyl) nitrosoamine in ACI/N rats, with special reference to induction of urinary bladder tumours. Gann 65: 13 (1974)

25.       Swann, P.F., Kaufman, D.C., Magee, P.N., Mace, R.: Induction of kidney tumours by a single dose of dimethylnitrosamtne: Dose-response and influence of diet and benzo-[al pyrene treatment. Brit. J. Cancer 41: 285 (1980)

26.       Swann, P.F., Magee., P.N.: Nitrosamine-induced carcinogenesis: The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethylsulphate and methyl methanesulphonate. Biochem. J. 110: 39 (1968)

27.       Magee, P.N., Barnes, J.M.: Carcinogenic nitroso compounds. Adv. Cancer Res. 10: 163 (1967)

28.      Diaz-Gomez, M.I., Swann, P.F., Magee, P.N.: The absorption and metabolism in rats of small oral doses of dimethylnitr’osamine. The implications for the possible hazard of dimethylnitrosamine in human food. Biochem. J. 164, 497 (1977)

29.       Criciute, L., Castegnaro, M., Sereziat, J.C.: Influence of ethyl alcohol on carcinogenesis with N-nitrosodimetlfylamine. Cancer Lett. 13. 345 (1981)

30.      Swann, P.F.: Metabolism of nitrosamines: Observations on the effect of alcohol on nitrosamine metabolism and on human cancer. In: Nitrosamines and human cancer. (P.N. Magee ed.) Banbury Report No. 1 2. p. 53. Cold Spring Harbour Laboratory, 1982.

31.       Doll, R., Reto, R.: The causes of cancer .J. Natl. Cancer Inst. 66: 1191 (1981)

32.       Boveri, T.: The origin of malignant tumours. Fisher-Verlag. Jena, 1914

33.       Burnet, E.M.: Cancer: Somatic-genetic considerations. Adv. Cancer Res. 28: 1 (1978)

34.       Strauss, D.S.: Somatic mutation, cellular differentiation and cancer causation, J. Natl. Cancer Inst. 67: 233 (1981)

35.       Harris, H.: Some thoughts about genetics, differentiation and malignancy. Somatic Cell Genet. 5: 923 (1979)

36.       Rubin, H.: Is somatic mutation the major mechanism of malignant transformation? J. Nad. Cancer Inst. 64: 995 (1980)

37.       Pitot, H.C., Heidelberger, C.: Metabolic regulatory circuits and carcinogenesis. Cancer Res. 23: 1694 (1963)

38.      Ames. B.N., Curney, E.C., Miller, J.A., Bartsch, H.: Carcinogens as frameshift mutagens. Proc. Natl. Acad. Sci. (U.S.) 69: 3128 (1972)

39.       Ames, B.N., McCann, J., Yamasaki, E.: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 31: 347 (1975)

40.      Rinkus, S.-J„ Legator, M.S.: Chemical characterisation of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhtmunum system. Cancer Res. 39: 3289 (1979)

41.       Ames. B.N., Kämmen, H.O., Yamasaki, E.: Hair dyes are mutagenic. Proc. Natl. Acad. Sci. (U.S.) 72: 2423 (1975)

42.       Athanasiou, K., Kyrtopoulos, S.A.: Mutagenic and clastogenic effects or organic extracts from the Athenian drinking water. Sei. Total Environ. 27: 1 13 (1983)

43.       Barrett, J.G., Tsutsui, T., Ts’ o P.O.: Neoplastic transformation induced by a direct perturbation of DNA. Nature (London) 274: 229 (1978)

44.       Hart, R.W., Setlow, R.B.: Direct evidence that pyrimidine dimers in DNA result in neoplastic transformation. In: Molecular mechanisms for repair of DNA (P.C. Hanawalt, R.B. Setlow eds.) Part B, p. 719; Plenum Press, N.Y., 1975

45.       Cleaver, J.E., Bootsma, D., Xeroderma Pigmentosum, Biochemical and genetic characteristics. Ann, Rev. Genet. 9:19 (1975)

46.       Hanawalt, P.C., Cooper, P.K., Genesan, A.K., Smith, C.A.: DNA repair in bacteria and mammalian cells .Ann. Rev. Biochem. 48: 783 (1979)

47.       Setlow R.B.: Repair: Different basic mechanisms in DNA repair. Arch. Toxico. Suppl. 3: 217 (1980)

48.      Pierce, G.B.: Differentiation of normal and malignant cells. Fed. Proc. 29: 1248 (1970)

49.       Roberts, J.J.: Garcinogen-induced DNA damage and its repair. Brit. Med. BuU. 36: 25 (1980)

50.       Grover, P.L. (ed.): Chemical carcinogens and DNA,Volumes I and II. CRC Press, Boca Raton, 1979

51.       Pegg, A.E.: Formation and metabolism of alkylated nucleosides. Possible role in carcinogenesis by nitroso compounds and alkylating agents. Adv. Cancer Res. 25: 195 (1977)

52.       Singer, B.: All oxygens in nucleic acids react with carcinogenic ethylating agents. Nature (London) 264: 333 (1976)

53.       Lawley, P.D.: Methylation of DNA by carcinogens: Some applications of chemical analytical methods. In: Screening tests in chemical carcinogenesis (R. Montesano, H. Bartsch, L. Tomatis eds.). IARC Scientific Publications No. 12, p. 181. IARC, Lyon, 1976

54.       Margisson, G.P., O’ Connor, P.J.: Nucleic acid modification by N-nitroso compounds. In ref. 50, Vol. I, p. 111

55.       Goth, R., Rajewsky, M.F.: Molecular and cellural mechanisms associated with pulse-carcinogenesis in the rat nervous system by ethylnitrosourea: Ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues. Z. Krebsforsch. 82: 37 (1974)

56.       Frei, J.V., Swenson, D.H., Warren, W., Lawley, P.D.: Alkylation of deoxyribonucleic acid in vivo in various organs of C57BI mice by the carcinogens N-methyl-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Biochem J, 174: 1031 (1978)

57.       Gerchman, L.L., Ludlum, D.B.: The properties of 06-methylguanine in templates for RNA polymerase. Biochim. Biopys. Acta 308: 310 (1973)

58.       Newboid, R.F., Warren, W., Medcalf, A.C.S., Amos, J.: Mutagenicity of carcinogenic methylating agents is associated with specific DNA modification. Nature (London) 283: 596 (1980)

59.       Perera, F.P., Weinstein, I.B.: Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation. J. Chron. Dis. 35: 581 (1982)

60.      Muller, R., Rajewsky, M.F.: Immunological quantification by high-affinity antibodies of 06-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res. 40: 887 (1980)

61.       Kyrtopoulos, S.A., Swann, P.F.: The use radioimmunoassay to study the formation and disappearence of 06-methyl-guanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration. J. Cancer Res. 98: 127 (1980)

62.       Hsu, I.C., Poirier, M.C., Yuspa, S.H., Yolken, R.H., Harris, C.C.: Ultrasensitive enzymatic radioimmunoassay (USE-RIA) detects femtomoles of acetylaminofluorene-DNA adducts. Carcinogenesis 1: 455 (1980)

63.       Kyrtopoulos, S.A., Hadjiloucas, E., Vrotsou, B.: Nondetection of Oe-methylguanine in rat DNA following in vivo treatment with large doses of cimetidine alone or in combination with sodium nitrite. Cancer Res. 42: 1962 (1982)

64.       Perera, F.C., Poirier, M.C., Yuspa, S.H., Nakayama, J., Jaretzki. A., Curnen, M.M., Knowles, D.M., Weinstein, I.B.: A pilot project in molecular cancer eridemiology: determination of benzo[a|pyrene-DNA adducts in animal and human tissues by radioimmunoassays. Carcinogenesis 3: 1405 (1982)

65.       Cerutti, P.A., Sessions, F., Hariharan, P.V., Lusby, A.: Repair of DNA damage induced by benzolojpyrene diol epoxides I and II in human alveolar tumour cells. Cancer Res. 38:2118 (1978)

66.       Κυρτόπουλος, Σ.Α.: Ν-Νιτρωδοενώσεις και καρκίνος του στομάχου. Ιατρική (υπό δημοσίευση)

67.       Cayama, Ε., Tsuda, Η., Sarma, D.S.A., Farber, Ε,: Initiation of chemical carcinogenesis requires cel) proliferation, Nature (London) 275: 60 (1978)

68.      Craddock, V.M.: Cell proliferation and experimental liver cancer. In: Liver cell cencer, (H.M. Cameron, D.A, Linsell, G.P. Warwich, eds.) p. 153, Elsevier, 1976

69.       Berenblum, L: Carcinogenesis as a biological problem. North-Holland, 1974

70.       Berenblum, I., Shubik, P.: The persistence of latent tumour cells induced in the mouse’s skin by a single application of 9, 10-dimethyl-1,2-benzanthracene. Brit. J. Cancer 3: 384 (1949)

71.       Besker, F.F.: Recent concepts of initiation and promotion in carcinogenesis. Amer. J. Pathoi. 105: 3 (1981)

72.       Diamond, L., O’Brien, T.G., Baird, W.: Tumour promoters and the mechanism of tumour promotion. Adv. Cancer Res. 32: 1 (1980)

73.       Newboid, R.F., Amos, J.: Inhibition of metabolic cooperation between mammalian cells in culture by rumour promoters. Carcinogenesis 2: 243 (1981)

74.       Trosko, J.E., Chang, C.C.: Chemical carcinogenesis as a consequence of alterations in the structure and function of DNA. In ref. 50, Vol. II, p. 181

75.       Pitot, H.V.: Fundamentals of Oncology. Marcel Dekker Inc., N.Y., 1981

76.       Temin, H.M.: We still don’t understand cancer. Nature (London) 302: 656 (1983)