Τόμος 1 (1983) – Τεύχος 3 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 3 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title Ετεροειδή και Καρκίνος

Steroids in Cancer

Συγγραφέας – Author Μιχάλης Ν. Αλέξης

Κέντρο Βιολογικών Ερευνών, Εθνικό Ίδρυμα Ερευνών

Michalis N. Alexis

Biological Research Center, National Hellenic Research Foundation, Athens, Greéce

Παραπομπή – Citation Αλέξης, Μ.Ν.: Ετεροειδή και Καρκίνος, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 3: 195-206 (1983)

Alexis, M.N.: Steroids in Cancer, Epitheorese Klin. Farmakol. Farmakokinet. 3: 195-206 (1983)

Ημερομηνία Δημοσιευσης – Publication Date Οκτώβριος 1983 – October 1983
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Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords Ορμονικά στεροειδή, ορμονοεξάρτηση, καρκινογένεση

Steroid hormones, hormone-dependency, carcinogenesis

Λοιποί Όροι – Other Terms Άρθρο
Article
Περίληψη – Summary Steroid hormones are involved in carcinogenesis and in the hormone-dependent growth of a number of tumours of human tissues which are targets of these hormones. Cancer hormone-dependency has been attributed to the presence of specific hormone receptors. Qualitative and quantitative estimation of these receptors may serve for prognosis in cancer and for an assessment of response to endocrine therapy, both ablative and additive. An evaluation of hormone receptors as an independent parameter for prognosis and choice of the appropriate therapeutic regiment of either primary or advanced metastatic cancer is also presented. Νon-response to endocrine manipulations of a number of apparently hormone-dependent tumours is discussed in relation to the mechanism of steroid hormone action in the target cell and the known effects antihormones have on this mechanism. Deviations from the hormone-dependent response are attributed to a number of conditions and to errors in assaying tumour hormone-dependency. An evaluation of the importance of the assays as well as a reference to common errors in methodology and the parameters affecting reproducibility of the assays is also presented.
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