Τόμος 1 (1983) – Τεύχος 4 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 4 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title Αλληλεπιδράσεις in Vitro και in Vivo των Αντιμικροβιακών Χημειοθεραπευτικών

In Vitro and in Vivo Interactions of Antimicrobial Chemotherapeutics

Συγγραφέας – Author Ελένη Γιαμαρέλλου

Α’ Προπαιδευτική Παθολογική Κλινική Πανεπιστημίου Αθηνών

Helen Giamarellou

First Department of Propedeutic Medicine, Athens University School of Medicine

Παραπομπή – Citation Γιαμαρέλλου, Ε.: Αλληλεπιδράσεις in Vitro και in Vivo των Αντιμικροβιακών Χημειοθεραπευτικών, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 1(4): 243-250 (1983)

Giamarellou, H.: In Vitro and in Vivo Interactions of Antimicrobial Chemotherapeutics, Epitheorese Klin. Farmakol. Farmakokinet. 1(4): 243-250 (1983)

Ημερομηνία Δημοσιευσης – Publication Date Ιανουάριος 1984 – January 1984
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Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords Αντιμικροβιακά χημειοθεραπευτικά, β-λακτάμες

Antimicrobial chemotherapeutics, β-lactams

Λοιποί Όροι – Other Terms Άρθρο
Article
Περίληψη – Summary The interaction of various antimicrobial hemotherapeutics on the bacterial and molecular level are reviewed. On the bacterial level the possibility of obtaining synergism, addition, indifference and antagonism, when combination of the various groups of chemotherapeutics and particularly between bacteriostatic and bactericidal drugs is commented. After a thorough description of the terms, explanations for the obtained interactions are offered. The newly described mechanisms of antagonism, based on β-lactamase induction, are also discussed. The reasons for antimicrobial combinations are. explained and their indications are reported. Molecular interactions when various older and newer (3-lactams are combined either in vitro or in vivo with the aminoblycosides are referred. The influence of time, temperature, pH and medium composition upon the obtained in vitro inactivations of the aminoglycosides are reviewed and the importance of the in vitro observations, when transferred in the in vivo observations, discussed. Particular interest is given on specific situations i.e. renal insufficiency, abscesses, simultaneous i.v. infusion, where the possibility of in vivo inactivation of the aminoglycosides by the β-lactams is enhanced. The least and the most inactivated among the aminoglycosides as well as the least and the most inactivating β-lactams are also listed.
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