Τίτλος – Title | Αλληλεπιδράσεις in Vitro και in Vivo των Αντιμικροβιακών Χημειοθεραπευτικών
In Vitro and in Vivo Interactions of Antimicrobial Chemotherapeutics |
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Συγγραφέας – Author | Ελένη Γιαμαρέλλου
Α’ Προπαιδευτική Παθολογική Κλινική Πανεπιστημίου Αθηνών Helen Giamarellou First Department of Propedeutic Medicine, Athens University School of Medicine |
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Παραπομπή – Citation | Γιαμαρέλλου, Ε.: Αλληλεπιδράσεις in Vitro και in Vivo των Αντιμικροβιακών Χημειοθεραπευτικών, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 1(4): 243-250 (1983)
Giamarellou, H.: In Vitro and in Vivo Interactions of Antimicrobial Chemotherapeutics, Epitheorese Klin. Farmakol. Farmakokinet. 1(4): 243-250 (1983) |
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Ημερομηνία Δημοσιευσης – Publication Date | Ιανουάριος 1984 – January 1984 | |
Γλώσσα Πλήρους Κειμένου – Full Text Language |
Ελληνικά – Greek | |
Παραγγελία – Αγορά – Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) – Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords | Αντιμικροβιακά χημειοθεραπευτικά, β-λακτάμες
Antimicrobial chemotherapeutics, β-lactams |
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Λοιποί Όροι – Other Terms | Άρθρο Article |
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Περίληψη – Summary | The interaction of various antimicrobial hemotherapeutics on the bacterial and molecular level are reviewed. On the bacterial level the possibility of obtaining synergism, addition, indifference and antagonism, when combination of the various groups of chemotherapeutics and particularly between bacteriostatic and bactericidal drugs is commented. After a thorough description of the terms, explanations for the obtained interactions are offered. The newly described mechanisms of antagonism, based on β-lactamase induction, are also discussed. The reasons for antimicrobial combinations are. explained and their indications are reported. Molecular interactions when various older and newer (3-lactams are combined either in vitro or in vivo with the aminoblycosides are referred. The influence of time, temperature, pH and medium composition upon the obtained in vitro inactivations of the aminoglycosides are reviewed and the importance of the in vitro observations, when transferred in the in vivo observations, discussed. Particular interest is given on specific situations i.e. renal insufficiency, abscesses, simultaneous i.v. infusion, where the possibility of in vivo inactivation of the aminoglycosides by the β-lactams is enhanced. The least and the most inactivated among the aminoglycosides as well as the least and the most inactivating β-lactams are also listed. | |
Αναφορές – References | 1. Klein, M., Kimmelmann, L.J.: The correlation between the inhibition of drug resistance in streptomycin and penicillin. J. Bad. 54; 363 (1947)
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Res. 32: 25 (1982). |
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ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1983 – ANNUAL SUBSCRIPTION 1983 | |
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