Τόμος 1 (1983) – Τεύχος 4 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 4 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Beta-Adrenergic Receptors

Διεύθυνση Καρδιολογίας του Πανεπιστημίου της Πολιτείας του Οχάιο, ΗΠΑ

Harisios Boudoulas

Divison of Cardiology, The Ohio State University, Columbus, Ohio, USA

Boudoulas, H.: In Vitro and in Vivo Interactions of Antimicrobial Chemotherapeutics, Epitheorese Klin. Farmakol. Farmakokinet. 1(4): 251-260 (1983)

β-adrenergic, stimulation, blockade

2.         Lands, A.M., Arnold, A., McAuliff, J.P., Luduéna, F.P., Brown, J.G. Jr.: Differentiation of receptor systems activated by sympathomimetic amines. Nature 214: 597 (1967)

3.         Langer, S.Z.: Presynaptic regulation of catecholamine release. Biochem. Pharmacol. 23: 1793 (1974)

4.         Starke, K., Taube, H.D., Borowski, G.: Presynaptic receptor systems in catecholaminergic transmission. Biochem. Pharmacol. 26: 259 (1977)

5.         Αποστολάκης, M.I.: Στοιχεία φυσιολογίας του ανθρώπου. Τόμος Β’, Τείχος I, σελ. 226, Εκδόσεις Αφοί Κυριακϊδη, Θεσσαλονίκη, 1983

6.         Watanabe, A.Μ., Jones, L.R., Manalan, A.S., Besch, H.R. Jr.: Cardiac Autonomic Receptors. Recent concepts from radiolabeled ligand-binding studies. Circul. Bes. 50: 162 (1982)

7.         Motulsky, H.J., Insel, P.A.: Adrenergic Receptor in Man. Direct Identification, Physiologic regulation and clinical alterations. N. Engl. J. Med. 307: 18 (1982)

8.         Pollet, R.J., Levey, G.S.: Principles of membrane Receptors and their application to Clinical Medicine. Ann. Ini. Med. 92: 663 (1980)

9.         Heisimer, J.A., Lefkowitz, R.J.: Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. J. Lab. Clin. Med. 100: 641 (1982)

10.       Short, R.G.L, Lefkowitz, R.J., Caron, M.G.: Purification of the beta-adrenergic receptor. J. Biol. Chem. 256: 5820 (1981)

11.        Schorr, R.G.L., Strohsacker, M.W., Levin, T.N., Lefkowitz, R.J., Caron, M.G.: The b)-adrenergic receptor of the turkey erythrocyte: molecular heterogeneity revealed by purification and photoaffinity labeling. J. Biol. Chem. 257: 12341 (1982)

12.       Lavin, T.N., Nambi, P., Heald, S.L., Jeffs, P.W., Lefkowitz, R.J., Caron, M.G.: ,i:T-labelled p-azidobenzylcarazolol, a photoaffinity label for the b-adrenergic receptor: characterization of the ligand and photoaffinity labeling of b­1 and b2-adrenergic receptors. J. Biol. Chem. 257: 12332 (1982)

13.       De Lean A., Stadel, J.M., Lefkowitz, R.J.: A tenary complex model explains the agonist-specific binding of the adenylate cyclase-coupled beta-adrenergic receptor. J. Biot. Chem. 255: 7108 (1980)

14.       Limbird, LE., Gill, D.M., Lefkowitz, R.J.: Agonistpromed coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proc. Natl. Acad. Set. USA 77: 775 (1980)

15.       Cassel, D., Selinger, Z.: Mechanism of adenylate cyclase by cholera toxin: inhibition of GTP hydrolysis at the regulatory site. Proc. Natl Acad. Set. USA 74: 3307 (1977)

16.       Sutherland, E., Robinson, A., Butcher, R.: Some aspects of the biological role of adenosine 3′-5′-monophosphate (cyclic AMP). Circulation 37: 279 (1968)

17.       Limbird, L.E., Lefkowitz, R.J.: Agonist-induced increase in apparent beta-adrenergic receptor size. Proc. Natl. Acad. Sci USA 75: 228 (1978)

18.       Μπουντούλας, X., Γκελερής, Π.: Στεφανιαία κυκλοφορία. Η χρησιμοποίηση των φαρμάκων που αποκλείουν τους β-αδρενεργικούς υποδοχείς στη στεφανιαία νόσο. Materia Medica Greca 7: 405 (1979)

19.       Carlsson, E., Danlof C-G., Hedberg, A., Persson, H., Tang-strand, B.: Differentiation of cardiac chromotropic and inotropic effects of beta-adrenergic agonists. Naunyn Schmidebergs. Arch. Pharmacol. 300: 101 (1977) :

20.      Mickey, J.V., Tate, R., Lefkowitz, R.J.: Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (—) isoproterenol in vitro. J. Biol. Chem. 250: 5727 (1975)

21.       Leier, C.B., Nelson, S., Magorien, R.D., Boudoulas, H., Gibb, L., Uververth, D.V.: Heart rate responsiveness after sustained chronotropic stimulation with a beta-adrenergic receptor agonist. J. Lab. Clin. Med. 101: 955 (1983)

22.       Lefkowitz, R.J., Wessels, M.R., Stadel, J.M.: Hormones, receptors and cyclic AMP: Their role in target cell refractoniness. Curr. Top. Regut. 205 (1980)

23.       Chuang, D.M., Costa. E.: Evidence for internalization of the recognition site of the beta-adrenergic receptor during receptor subsensitivitv induced by (—) isoproterenol. Proc. Natl. Acad. Sei USA 76: 3024 (1979)

24.       Mukherjee, C., Caron, M.G., Lefkowitz, R.J.: Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. Endocrinology 99: 347 (1976)

25.       Boudoulas, H., King, B., Wooley, W.F.: Mitral valve prolapse: A marker for anxiety or overlapping phenomenon. Psychopathology, Vol. 17. 1984 (in press)

26.       Boudoulas, H., Reynolds, J.C., Mazzaferri, E., Wooley, C.F.: Metabolic studies in mitral valve prolapse syndrome: A  Neuroendocrine-cardiovascular prosess. Circulation 61: 1200 (1980)

27.       Boudoulas, H., Reynolds. J.C., Mazzaferri, E., Wooley, C.F.: Mitral valve prolapse syndrome. The effect of adrenergic stimulation. J. Am. Coleg. Cardiol. October 1983, In press

28.      Gläubiger, G., Tsai, B.S., Lefkowitz, R.J.: Chronic guanethidine treatment increases cardiac beta-adrenergic receptors. Nature 273: 240 (1978)

29.       Gläubiger, G., Lefkowitz, R.J.: Elevated beta adrenergic number after chronic propranolol treatment. Biochem. Biophys. fíes. Commun. 78: 720 (1977)

30.      Nies, A.S., Acrons, R.d., Brammel, Fl.L, Molinoff, P.B.: Increased density of beta-adrenergic receptors on lymphocytes following propranolol treatment. Clin. Res. 27:445A (1979)

31.       Davies. A.O., Lefkowtz, R.J.; Regulation of adrenergic receptors. In: Receptor regulation. (Lefkowitz, R.J., ed.), p. 85, Chapman and Hall, N.Y., 1981

32.       Boudoulas, H., Lewis, R.P., Kates, R.E., Dalamangas, G.: Hypersensitivity to adrenergic stimulation after propranolol withdrawal in normal subjects. Ann. Intern. Med. 87: 433 (1977)

33.       Alderman, E.L, Coïtant, D.J., Wettach, G.E., Harrison, D.            C.: Coronary artery Syndromes after sudden propranolol withdrawal. Ann. Intern. Med. 81: 625 (1974)

34.       Schocken, D.D., Roth, G.S.: Reduced b-adrenergic receptor concentrations in agein man. Nature 267: 856 (1977).

35.       Williams, R.s„ Guthrow, C.E., Lefkowitz, R.J.: b-adrenergic receptors of human lymphocytes and unaltered by hyperthyroidims. J. Clin. Endocrinol. Metab. 48: 503 (1979)

36.       Davies, A.O., Lefkowitz, R.J.: Corticosteroid-induced differential regulation of b-adrenergic receptors in circulation human polymorphonuclear leukocytes and mononuclear leukocytes. J. din. Endocrinol. Metab. 51: 599 (1981)

37.       Davies, B., Sudera, D„ Mathias, C., Bannister, R., Sever, R.: Beta receptors in orthostatic hypotension. N. Engl. J. Med. 305: 1018 (1981)

38.      Jenning, G., Bolik, A., Ester, M.: Beta receptors in orthostatic hypotension. N. Engl J. Med. 305: 1019 (1981)

39.       Colucci, W.S.. Alexander, R.W., Williams, G.H., Rude, R.E., Holman, B.L., Konstan, M.A., Wynne, J., Mudge, G.H. Jr., Braunwald, E.: Decreased lymphocyte beta-adrenergic receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. N. Engl. J. Med. 305: 185 (1981)

40.      Szentivanyi, A.: The beta adrenergic theory of the atopic abnormality in bronchial asthma. J. Allergy 42: 203 (1968)

41.       Sano, Y., Ruprecht, H., Mano, K„ Begley, M., Bewtra, A., Townley, R.: Leukocyte beta-adrenergic receptor assay in normal and asthmatics. Clin. Res. 27: 403A (1977)

42.       Brooks, S.M., McGowan, K., Bernstein, I.L., Altenau, P., Peagler, J.: Relationship between numbers of beta-adrenergic receptors in lymphocytes and disease severity in asthma. J. Allergy CUn. Immunol 63: 401 (1979)

43.       Kariman, K.: Beta-adrenergic receptor binding lymphocytes from patients with asthma. Lung. 158: 41 (1980)

44.       Ruoho, A.E., deClerque, J.L., Bussey, W.W.: Characterization of granulocyte b-adrenergic receptors in atopic eczema. J. Allergy din. Immunol. 66: 46 (1980)

45.       Davis, P.B., Shelhamer, J.R., Kaliner, M.: Abnormal Adrenergic and cholinergic sensitivity in cystic fibrosis. N. Engl. J. Med. 302: 1453 (1980)

46.       Davis, P.B., Braunstein, M„ Jay, C.: Decreased adenosine 3′-5′-monophosphate response to isoproterenol in cystic fibrosis leukocytes. Pediatr. Res. 12: 703 (1978)

47.       Greenacre, J.K., Conolly, M.E.: Desensitization of the adrenoreceptor of lymphocytes from normal subjects and patients with phenochromocytoma; studies in vivo. Eur. J. Clin. Pharmacol 5: 191 (1978)

48.      Roger, J.M., Boudoulas, H., Malarkey, W.B., Wooley, C.F.: Mitral valve prolapse: Disorder catecholamine regulation with intravascular volum manenvers. Clinical Research. In press, 1983

49.       Clark, R.W., Boudoulas, H., Schaal, S.F., Schmidt, H.S.: Adrenergic hyperactivity and cardiac abnormality in primary disorders of sleep. Neurology 30: 113 (1980)

50.       Btdart, J.M., Motte, P., Bohuon, C., Bellet, D.: Lymphocytes aminergic binding changes in chronic lymphocytic leukaemia. Leuk. Res. 5: 443 (1981)

51.       Paietta, T., Schwarzmeier, J.D.: lodohydroxybenzylpindolol binding and adenylate cyclase activities in normal lymphocytes and leukemic cells. Adv. Cyclic Nucleotide Ftes. 14: 682A (1981)

52.       Banerjee, S.P., King, L.S., Riggi, S.J., Chandre, S.K.: Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature 268: 454 (1977)