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Τίτλος – Title
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Συγκριτική Μελέτη της Συχνότητας του Πολυμορφισμού -759C/T του 5-HT2C Υποδοχέα σε Υγιείς Εθελοντές, σε Ασθενείς με Σακχαρώδη Διαβήτη Τύπου 2 και σε Ασθενείς με Στεφανιαία Νόσο στον Ελληνικό Πληθυσμό Comparative Study of Frequency of the Polymorphism -759 C/T of the 5 HT2C Receptor in Healthy Volunteers, in Patients with Type II Diabetes Mellitus and in Patients with Coronary Artery Disease in the Greek Population |
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Συγγραφέας – Author
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Μαρία Ιορδανίδου1, Ιωάννης Πετρίδης1, Μιχαήλ Β. Βασιλειάδης2, Κώστας Αρβανιτίδης1, Γεώργιος Μπουγιούκας3, Άννα Ταυρίδου1 και Ευάγγελος Γ. Μανωλόπουλος1 1Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Δημοκρίτειο Πανεπιστήμιο Θράκης, Αλεξανδρούπολη, Ελλάς, 2Διαβητολογικό Ιατρείο Κρατικής Παθολογικής Κλινικής και 3Πανεπιστημιακή Καρδιοθωρακοχειρουργική Κλινική Πανεπιστημιακού Γενικού Νοσοκομείου Αλεξανδρούπολης, Αλεξανδρούπολη, Ελλάς Maria Iordanidou1, John Petridis1, Kostas Vassiliadis2, Kostas Arvanitidis1, George Bougioukas3, Anna Tauridou1 and Vangelis G. Manolopoulos1 1Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 2Outpatient Diabetic Medical Clinic Clinic and 3Cardiothoracic Surgery Clinic, Academic General Hospital of Alexandroupolis, Alexandroupolis, Greece |
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Παραπομπή – Citation
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Ιορδανίδου,Μ., Πετρίδης,Ι., Βασιλειάδης,Μ.Β., Αρβανιτίδης,Κ.,Μπουγιούκας,Γ., Ταυρίδου,Α., Μανωλόπουλος,Ε.Γ., : Συγκριτική Μελέτη της Συχνότητας του Πολυμορφισμού -759C/T του 5-HT2C Υποδοχέα σε Υγιείς Εθελοντές, σε Ασθενείς με Σακχαρώδη Διαβήτη Τύπου 2 και σε Ασθενείς με Στεφανιαία Νόσο στον Ελληνικό Πληθυσμό, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 25: 46-48 (2007)
Iordanidou,Μ., Petridis,J., Vassiliadis,K., Arvanitidis,K., Bougioukas,G., Tauridou,A., Manolopoulos,V.G., : Comparative Study of Frequency of the Polymorphism -759 C/T of the 5 HT2C Receptor in Healthy Volunteers, in Patients with Type II Diabetes Mellitus and in Patients with Coronary Artery Disease in the Greek Population, Epitheorese Klin. Farmakol. Farmakokinet. 25: 46-48 (2007)
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Ημερομηνία Δημοσιευσης – Publication Date
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2007 – 2007
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Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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5-HT2C receptor gene polymorphism, type ΙI diabetes mellitus, coronary artery disease, Greek population
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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5-HT2C receptor is one of fourteen 5-HT receptor subtypes expressed in the CNS and iIt’s gene is located in the X-chromosome (Xq24). Both pharmacological and genetic studies reveal that it contributes substantially to the serotonergic regulation of a wide variety of behavioral and physiological processes such as feeding and glucose homeostasis. The polymorphism -759C/T in the serotonin 2C (5HT2C) receptor promoter region has been associated with the development of type II diabetes mellitus and obesity in normal subjects, with the frequency of the T allele being higher in subjects without diabetes mellitus and obesity. Furthermore, the 5-HT2C-receptor gene -759C/T polymorphism has been associated with antipsychotic agents-induced weight gain. The T allele may be a protective factor for the development of weight gain in schizophrenic patients. Objective: To determine the distribution of the -759C/T polymorphism of the 5HT2C receptor among normal controls, in patients with type ΙI diabetes mellitus and in patients with coronary artery disease in the Greek population. Methods: Ιn this study participated 50 healthy volunteers, 50 patients with type ΙI diabetes mellitus and 50 with coronary artery disease. The experimental process included the extraction of genomic DNA from peripheral blood and then its analysis for the -759C/T polymorphism of the 5-HT2C receptor using PCR-RFLP method. Results – Discussion: In the group of healthy volunteers the frequency of T-allele in normal controls (19.2%) is in accordance to that reported in European populations and in patients with type II diabetes mellitus and in patients with coronary artery disease is 8.5% and 17.7%, respectively. |
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Αναφορές – References
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1. Giorgetti M., Tecott L.H.: Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. Eur. J. Pharmacol. 488(1-3): 1-9 (2004) 2. Smith B.M., Thomsen W.J., Grottick A.J.: The potential use of selective 5-HT2C agonists in treating obesity. Opin. Investig. Drugs. 15: 257-266 (2006) 3. Shih J.C., Zhu Q., Chen K.: 1996. Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene. Brain Res. 73: 59-62 (1996) 4. Reynolds G.P., Hill M.J., Kirk S.L.: The 5-HT2C receptor and antipsychotic-induced weight gain – mechanisms and genetics. J. Psychopharmacol. 20: 15-17 (2006) 5. Miller D.D., Ellingrod V.L., Holman T.L., Buckley P.F., Arndt S.: Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism. J. Med. Genet. Part B (Neuropsych. Genet.) 133B: 97-100 (2005) 6. Ellingrod V.L., Perry P.J., Ringold J.C., Lund B.C., Bever-Stille K., Fleming F., Holman T.L., Miller D.: Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine. Am. J. Med. Genet. Part B (Neuropsych. Genet.) 134: 76-78 (2005) 7. Reynolds G.P., Zhang A.J., Zhang X.B.: Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet 359: 2086-2087 (2002) 8. Reynolds G.P., Zhang Z., Zhang X.: Polymorphism of the promoter region of the serotonin 5-HT2C receptor gene and clozapine-induced weight gain. Am. J. Psychiatry 160: 677-679 (2003) 9. Pooley E.C., Fairburn C.G., Cooper Z., Sodhi M.S., Cowen P.J., Harrison P.J.: A 5-HT2C receptor promoter polymorphism (HTR2C – 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Am. Med. Genet. B Neuropsychiatr. Genet. 126: 124-127 (2004) 10. Yuan X., Yamada K., Ishiyama-Shigemoto S., Koyama Q., Nonaka K.: Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia 43: 373-376 (2000) 11. Ellingrod V.L., Miller D., Ringold J.C., Perry P.J.: 2004. Distribution of the serotonin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controls. Psychiatr. Genet.14: 93-95 (2004) |
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Online ISSN 1011-6575
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