Τόμος 25 (2007) – Τεύχος 2+3 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 25 (2007) – Issue 2+3– Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Άσθμα Φαρμακευτικής Αιτιολογίας

Drug Induced Asthma

Συγγραφέας – Author

Σοφία Κωστούδη και Μαρία Μυρωνίδου-Τζουβελέκη

Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς

Sofia Kostoudi and Maria Mironidou-Tzou­veleki

Department of Pharmacology, Medical School, Aristotle University, Thessaloniki, Greece

Παραπομπή – Citation
Κωστούδη,Σ., Μυρωνίδου-Τζουβελέκη,Μ. : Άσθμα Φαρμακευτικής Αιτιολογίας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 25: 163-174 (2007)
Kostoudi,S., Mironidou-Tzou­veleki,M. : Drug Induced Asthma, Epitheorese Klin. Farmakol. Farmakokinet. 25: 163-174 (2007)
Ημερομηνία Δημοσιευσης – Publication Date
10 Οκτομβρίου 2007 – 2007-10-10
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Άσθμα φαρμακευτικής αιτιολογίας, βρογχόσπασμος, ΜΣΑΦ, β-αποκλειστές, αντιγλαυκωματικά φάρμακα, αναισθητικοί παράγοντες, σκιαγραφικές ουσίες, εξαρτησιογόνες ουσίες
Drug induced asthma, bronchospasm, NSAIDs, β-blockers, glaucoma drugs, anaesthetic agents, radiocontrast media, illicit drugs
Λοιποί Όροι – Other Terms

Στατιστική Μελέτη

Statistical Study

Περίληψη – Summary

Το άσθμα είναι νόσος του αναπνευστικού συστήματος που χαρακτηρίζεται από χρόνια φλεγμονώδη εξεργασία των αεροφόρων οδών. Οι χρόνια φλεγμαίνοντες αεροφόροι οδοί παρουσιάζουν υπεραντιδραστικότητα, όταν εκτεθούν σε διάφορα ερεθίσματα ή εκλυτικά αίτια, με αποτέλεσμα να αποφράσσονται λόγω βρογχόσπασμου, βυσμάτων βλέννης και φλεγμονώδους εξοίδησης. Οι συνηθέστεροι αναφερόμενοι εκλυτικοί παράγοντες είναι οι λοιμώξεις, το κάπνισμα, ορισμένα φυσικά αίτια (αεροαλλεργιογόνα, ρύποι, σκόνη κ.λπ.) και η άσκηση. Υπάρχουν, όμως, και περιπτώσεις που ο βρογχόσπασμος και το άσθμα οφείλονται σε φάρμακα, γεγονός που συχνά παραβλέπεται στην κλινική πράξη. Στη μελέτη αυτή περιγράφονται τα φάρμακα που έχουν ως ανεπιθύμητη ενέργεια την πρόκληση βρογχόσπασμου και άσθματος. Τέτοια φάρμακα είναι τα ΜΣΑΦ (κυρίως το ακετυλοσαλικυλικό οξύ) και οι β-αποκλειστές, σπανιότερα δε τα αντιγλαυκωματικά φάρμακα, ορισμένοι αναισθητικοί παράγοντες, σκιαγραφικές και εξαρτησιογόνες ουσίες. Η γνώση του άσθματος φαρμακευτικής αιτιολογίας είναι σημαντική, αφού η διακοπή της χορήγησης του φαρμάκου συνοδεύεται από ύφεση της συμπτωματολογίας. Σπάνιες είναι οι περιπτώσεις που απαιτούν ιδιαίτερη θεραπευτική προσέγγιση της προκαλούμενης εκδήλωσης.

Asthma is a pulmonary disease charac­terized as a chronic inflammatory disorder of the air­ways. The airways are inflamed and this is associated with hyperresponsiveness to triggers or factors and this leads to airflow limitation because of broncho­spasm, mucus plug formation and swelling of the airway wall. Some of the most common asthma trig­gers are infections, cigarette smoke, several envi­ronmental factors (aeroallergens, air pollution, dust, e.t.c.) and exercise. However, bronchospasm and asthma can also be due to medications, something not usually considered as a risk factor for asthma in general practice. In this essay reference will be made to drugs that cause bronchospasm and asthma as a side effect. These drugs are NSAIDs (especially ace­tylsalicylic acid) and β-blockers, and not so often bronchospasm is a side effect induced by glaucoma drugs, radiocontrast media, several anaesthetic agents as well as illicit drugs. The diagnosis of drug-induced asthma is important, as withdrawing the of­fending medication can be beneficial in many cases and only in a few ones is another medical support essential.

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