Τόμος 24 (2006) – Τεύχος 2 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 24 (2006) – Issue 2 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Το Ενδοκανναβινοειδές Σύστημα και η νέα Προσέγγιση στη Φαρμακευτική Αγωγή της Παχυσαρκίας

Endo­cannabinoid System: A new Approach to the Obesity Drug Treatment

Συγγραφέας – Author

Υβόννη Δημουλά, Χριστίνα Μαρβάκη, Βαρβάρα Σοπίδου, Αναστασία Κανέλλου

Γενικό Τμήμα Βασικών Ιατρικών Μαθημάτων και Τμήμα Νοσηλευτικής Α, Σχολή Επιστημών Υγείας και  Πρόνοιας, Τεχνολογικό Εκπαιδευτικό Ίδρυμα (ΤΕΙ) Αθήνας, Αθήνα, Ελλάδα

Y. Dimoula, Ch. Marvaki, Β. Sopidou, A. Kanellou

Faculty of Health and Caring Professions, Tech­nological Educa­tional Institution (TEI) of Athens, Athens, Hellas

Παραπομπή – Citation
Δημουλά,Υ., Μαρβάκη,Χ., Σοπίδου,Β., Κανέλλου,Α. : Το Ενδοκανναβινοειδές Σύστημα και η νέα Προσέγγιση στη Φαρμακευτική Αγωγή της Παχυσαρκίας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 24: 95-102 (2006)
Dimoula,Y., Marvaki,Ch., Sopidou,B., Kanellou,A. : Endo­cannabinoid System: A new Approach to the Obesity Drug Treatment, Epitheorese Klin. Farmakol. Farmakokinet. 24: 95-102 (2006)
Ημερομηνία Δημοσιευσης – Publication Date
15 Σεπτεμβρίου 2006 – 2006-09-15
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Κανναβινοειδή, υποδοχείς κανναβινοειδών, παχυσαρκία, Ριμοναμπάντη
Cannabinoids, cannabinoid receptors, obesity, Rimonabant
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Τα τελευταία χρόνια στην Ιατρική των Δυτικών Χωρών εντατικοποιήθηκε η έρευνα γύρω από την πιθανή θεραπευτική δράση στοιχείων τα οποία είναι συστατικά της ινδικής κάνναβης. Οι έρευνες αυτές έφεραν στο φως αρκετές από τις ουσίες που περιέχονται στο φυτό. Στη συνέχεια, μελέτες σε πειραματόζωα και ανθρώπους αποκάλυψε ένα ενδογενές σύστημα, το ενδοκανναβινοειδές σύστημα. Πρόκειται για νευροδιαβιβαστικό σύστημα που συμμετέχει σε πολλές φυσιολογικές διαδικασίες. Πρόσφατα προσδιορίστηκε και η συμμετοχή του, εκτός από τη διαδικασία της όρεξης, και στο ισοζύγιο ενέργειας. Ακόμη παρασκευάστηκε συνθετική ουσία, η SR141716 ή rimonabant, που αναστέλλει τους υποδοχείς των κανναβινοειδών υποδοχέων CB1 και προκαλεί απώλεια βάρους, μείωση του λιπώδους ιστού και αλλαγή στο λιπιδαιμικό προφίλ και τη γλυκόζη αίματος.

During the last few years, the endo­cannabinoid system has been established as a very prominent scientific topic and many different regu­latory actions have been attributed to endocannabi­noids. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral func­tions. During the last few years, it has become evi­dent that multiple mechanisms of action, not only limited to the CNS, are involved in the endocan­nabinoid-mediated control of food intake and en­ergy balance. Recently, rimonabant, a selective cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardio­vascular risk factors in obese patients. In conclu­sion, evidence is provided that CB1-receptor block­ade may constitute a new, clinically relevant phar­macologic approach to improve obesity and the unfavorable cardiovascular risk profile in high-risk patients with dyslipidemia who are overweight or obese.

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