Τίτλος – Title
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Το Ενδοκανναβινοειδές Σύστημα και η νέα Προσέγγιση στη Φαρμακευτική Αγωγή της Παχυσαρκίας Endocannabinoid System: A new Approach to the Obesity Drug Treatment |
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Συγγραφέας – Author
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Υβόννη Δημουλά, Χριστίνα Μαρβάκη, Βαρβάρα Σοπίδου, Αναστασία Κανέλλου Γενικό Τμήμα Βασικών Ιατρικών Μαθημάτων και Τμήμα Νοσηλευτικής Α, Σχολή Επιστημών Υγείας και Πρόνοιας, Τεχνολογικό Εκπαιδευτικό Ίδρυμα (ΤΕΙ) Αθήνας, Αθήνα, Ελλάδα Y. Dimoula, Ch. Marvaki, Β. Sopidou, A. Kanellou Faculty of Health and Caring Professions, Technological Educational Institution (TEI) of Athens, Athens, Hellas |
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Παραπομπή – Citation
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Δημουλά,Υ., Μαρβάκη,Χ., Σοπίδου,Β., Κανέλλου,Α. : Το Ενδοκανναβινοειδές Σύστημα και η νέα Προσέγγιση στη Φαρμακευτική Αγωγή της Παχυσαρκίας, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 24: 95-102 (2006)
Dimoula,Y., Marvaki,Ch., Sopidou,B., Kanellou,A. : Endocannabinoid System: A new Approach to the Obesity Drug Treatment, Epitheorese Klin. Farmakol. Farmakokinet. 24: 95-102 (2006)
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Ημερομηνία Δημοσιευσης – Publication Date
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15 Σεπτεμβρίου 2006 – 2006-09-15
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords
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Κανναβινοειδή, υποδοχείς κανναβινοειδών, παχυσαρκία, Ριμοναμπάντη
Cannabinoids, cannabinoid receptors, obesity, Rimonabant
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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Τα τελευταία χρόνια στην Ιατρική των Δυτικών Χωρών εντατικοποιήθηκε η έρευνα γύρω από την πιθανή θεραπευτική δράση στοιχείων τα οποία είναι συστατικά της ινδικής κάνναβης. Οι έρευνες αυτές έφεραν στο φως αρκετές από τις ουσίες που περιέχονται στο φυτό. Στη συνέχεια, μελέτες σε πειραματόζωα και ανθρώπους αποκάλυψε ένα ενδογενές σύστημα, το ενδοκανναβινοειδές σύστημα. Πρόκειται για νευροδιαβιβαστικό σύστημα που συμμετέχει σε πολλές φυσιολογικές διαδικασίες. Πρόσφατα προσδιορίστηκε και η συμμετοχή του, εκτός από τη διαδικασία της όρεξης, και στο ισοζύγιο ενέργειας. Ακόμη παρασκευάστηκε συνθετική ουσία, η SR141716 ή rimonabant, που αναστέλλει τους υποδοχείς των κανναβινοειδών υποδοχέων CB1 και προκαλεί απώλεια βάρους, μείωση του λιπώδους ιστού και αλλαγή στο λιπιδαιμικό προφίλ και τη γλυκόζη αίματος. During the last few years, the endocannabinoid system has been established as a very prominent scientific topic and many different regulatory actions have been attributed to endocannabinoids. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral functions. During the last few years, it has become evident that multiple mechanisms of action, not only limited to the CNS, are involved in the endocannabinoid-mediated control of food intake and energy balance. Recently, rimonabant, a selective cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardiovascular risk factors in obese patients. In conclusion, evidence is provided that CB1-receptor blockade may constitute a new, clinically relevant pharmacologic approach to improve obesity and the unfavorable cardiovascular risk profile in high-risk patients with dyslipidemia who are overweight or obese. |
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Αναφορές – References
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