Τίτλος – Title
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Μελέτη της Δραστικότητας του Εκχυλίσματος Κρόκου Crocus Sativus Linnaeus στην Ιατρική και στην Αισθητική
Study of the Activity of the Extract of Crocus Sativus Linnaeus in Medicine and Aesthetics |
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Συγγραφέας – Author
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Παναγιώτα Καράτση1, Νίκη Παπαβραμίδου2, Αναστασία Γιαννακούλα3, Ελένη Κίντζιου4, Ιωάννης Τζουβελέκης5, Μαρία Μυρωνίδου-Τζουβελέκη6 1Αισθητικός Κοσμητολόγος MSc, 2Επίκουρη Καθηγήτρια, Ιστορία της Ιατρικής, Ιατρικό Τμήμα, Σχολή Επιστημών Υγείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, 3Καθηγήτρια Εφαρμογών, Τμήμα Τεχνολόγων Γεωπόνων, Α.ΤΕΙ Θεσσαλονίκης, 4Φαρμακοποιός, Καθηγήτρια Τμήματος Αισθητικής και Κοσμητολογίας, Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, ΤΕΙ Αθήνας, 5Μεταπτυχιακός Φοιτητής, Τμήμα Τεχνολόγων Γεωπόνων, Σχολή Τεχνολογίας Γεωπονίας και Τεχνολογίας Τροφίμων και Διατροφής, Α.ΤΕΙ Θεσσαλονίκης, 6Αναισθησιολόγος, Καθηγήτρια Φαρμακολογίας, Α΄ Εργαστήριο Φαρμακολογίας, Ιατρικό Τμήμα, Σχολή Επιστημών Υγείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης Panagiota Karatsi1, Niki Papavramidou2, Anastasia Giannakoula3, Eleni Kintziou4, Ioannis Tzouvelekis5, Maria Mironidou-Tzouveleki6 1Aesthetician Cosmetologist MSc; 2Assistant Professor, History of Medicine, Medical School, School of Health Sciences, Aristotle University, Thessaloniki, Hellas; 3Professor of Applications, Department Technologists Agronomy, A.TEI Thessaloniki, Hellas; 4Aesthetician Cosmetologist, Pharmacist, Professor of Aesthetics and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Egaleo, Hellas; 5Graduate Student, Department Technologists Agronomy, School of Agricultural Technology and Food Technology and Nutrition, A.TEI Thessaloniki, Hellas; 6Anaesthesiologist, Professor of Pharmacology, A’ Department of Pharmacology, Medical School, School of Health Sciences, Aristotle University, Thessaloniki, Hellas |
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Παραπομπή – Citation
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Καράτση,Π., Παπαβραμίδου,Ν., Γιαννακούλα,Α., Κίντζιου,Ε., Τζουβελέκης,Ι., Μυρωνίδου-Τζουβελέκη,Μ. : Μελέτη της Δραστικότητας του Εκχυλίσματος Κρόκου Crocus Sativus Linnaeus στην Ιατρική και στην Αισθητική, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 34: 65-74 (2016)
Karatsi,P., Papavramidou,N., Giannakoula,A., Kintziou,E., Tzouvelekis,I., Mironidou-Tzouveleki,M. : Study of the Activity of the Extract of Crocus Sativus Linnaeus in Medicine and Aesthetics, Epitheorese Klin. Farmakol. Farmakokinet. 34: 65-74 (2016)
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Ημερομηνία Δημοσιευσης – Publication Date
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2016 – 2016
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords
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Crocus sativus Linnaeus, σαφράν, κρόκος, ζαφορά, δρόγη
Crocus sativus L., Saffron, Crocus
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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Ο κρόκος (Crocus Sativus Linnaeus) είναι γνωστός από τα πανάρχαια χρόνια, ως αυτοφυές, αλλά και ως καλλιεργούμενο φυτό. Η παγκόσμια ετήσια παραγωγή του υπερβαίνει τους 200 τόνους. Οι αποξηραμένοι στύλοι του, γνωστοί και ως σαφράν, αποτελούν τη δρόγη του φυτού και είναι συνήθως έντονα χρωματισμένοι. Αυτός είναι το πιο ακριβό μπαχαρικό στον Κόσμο, λόγω των απαιτητικών διεργασιών συλλογής και ξήρανσης. Πολλές φορές το κόστος του ανταγωνιζόταν αυτό του χρυσού. Η χημική σύσταση των στύλων του έχει μελετηθεί εκτενώς. Φυτοχημικές αναλύσεις αναφέρουν μέχρι 150 χημικά συστατικά ανιχνεύσιμα στους απόξηραμένους στύλους, ενώ το ενδιαφέρον της σύγχρονης Ιατρικής για τους αποξηραμένους στύλους είναι μεγάλο. Την τελευταία δεκαετία τα συστατικά του απότελούν αντικείμενο πολλών πειραματικών μελετών σε βιοχημικό και φαρμακολογικό επίπεδο. Σκοπός της παρούσας εργασίας είναι η ανασκόπηση της βιβλιογραφίας σχετικά με τα νεότερα δεδομένα για τη δραστικότητα του εκχυλίσματος του Crocus Sativus Linnaeus στην Ιατρική και στην Αισθητική.
Saffron (Crocus Sativus Linnaeus) is known since ancient times, as wild and as a cultivated plant. Global production is more than 200 tons of saffron per year. The dried stilos of Crocus, known as saffron, are the drug of the plant and are usually strongly colored. It is the most expensive spice in the world because of the demanding collection and drying processes. Many times its cost was competing this of gold. The chemical composition of the stilous of Crocus has been studied extensively. Phytochemical analyzes indicate up to 150 chemicals detectable in dried spots. Modern medicine shows great interest for dried stilous of Crocus Sativus L. During the last decade Crocus Sativus L and its components have been the subject of many experimental studies in biochemical and pharmacological level. The purpose of this study is to make a review of the literature on the newest data about the activity of the extract of Crocus Sativus Linnaeus in Medicine and Aesthetic.
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Αναφορές – References1
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1. Ruck C.A.P.: Τα μυστικά της αρχαίας Ελευσίνας. Εκδόσεις κυκεών tales. Αθήνα 2009
2. Grilli Caiola M, Canini A.: Looking for Saffron’s (Crocus sativus L.) Parents. Funct. Plant Sci. Biotechnol. 4: 1-14 (2010) 3. Agayev Y.M., Zarifi E., Fernandez J.-A.: A study of karyotypes in the Crocus sativus aggregate and origin of cultivated saffron. Hacta Hort. 850: 47-54 (2010) 4. Carmona M., Sánchez A.M., Ferreres F., et. al.: Identification of the flavonoid fraction in saffron spice by LC/DAD/MS/MS: comparative study of samples from different geographical orgins. Food Chem. 2: 445-450 (2007) 5. Poma A., Fontecchio G., Carlucci G., et.al.: Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm. Antiallergy Agents Med. Chem. 11: 37-51 (2012) 6. Fernandez J.A.: Biology, biotechnology and biomedicine of saffron. Recent Res. Dev. Plant Sci. 2: 127-159 (2004) 7. Ταχμαζίδης Π.: Ο κρόκος της Κοζάνης, 1980 8. Ulbricht C., Conquer J., Costa D., et al.: An evidence-based systematic review of saffron (Crocus sativus) by the Natural Standard Research Collaboration. J. Diet. Suppl. 8: 58-114 (2011) 9. Shultes R.E.(Ed.): The kingdom of plants. In: Medicines from the earth; Thomson WAR, Ed.; McGraw-Hill Book Co.: New York, 1978; pp. 208 10. Παπανδρέου Μ.: Mελέτη του ρόλου συστατικών των στύλων του φυτού Crocus Sativus και άλλων ενδημικών ειδών Crocus σε νευροπροστατευτικούς μηχανισμούς με έμφαση στη νόσο του Αlzheimer. Διδακτορική διατριβή, 2010 11. Delgado M.C., Aramburu A.Z., Dias-Marta G.L.A.: The chemical composition of saffron: Color, taste and aroma. Editorial Bomarzo SL, Albaceta, 2006 12. Negbi M.: Sterility and Improvement of Saffron Crocus. Proceedings of the International Conference on Saffron (Crocus Sativus L.) L’Àquilla, Italy, 27-29 October, 1989; 1990; pp. 183-207 13. Aytekin A., Acikgoz A.O.: Hormone and microorganism treatments in the cultivation of saffron (Crocus sativus L.) plants. Molecules 13: 1135-1147 (2008) 14. Escribano J., Díaz-Guerra M.J., Riese H.H., et. al: The cytolytic effect of a glyco-conjugate extracted from corms of saffron plant (Crocus sativus) on human cell lines in culture. Planta Med. 66: 157-162 (2000) 15. Rubio M.A., Fernández N.P., Fernández J.A., Gómez-Gómez L.: Glucosylation of the saffron apocarotenoid crocetin by a glucosyltransferase isolated from Crocus sativus stigmas. Planta 219: 955-966 (2004) 16. Pfander H., Schurtenberger H.: Biosynthesis of C20-carotenoids in Crocus sativus. Phytochemistry 21: 1039-1042 (1982) 17. Liao Y.H., Houghton P.J., Hoult J.R.S.: Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J. Nat. Prod. 62: 1241-1245 (1999) 18. Eugster C.H., Hürlimann H., Leuenberger H.J.: Crocetindialdehyd und crocetinhalbaldehyd als blütenfarbstoffe von Jacquinia angustifolia. Helv. Chim. Acta. 52: 806-807 (1969) 19. Tandon J.S., Katti S.B.: Crocetin-dialdehyde from Coleus forskohlii BRIQ., Labiatae. Helv. Chim. Acta 62: 2706-2707 (1979) 20. Abdullaev F.I.: Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp. Biol. Med. 227: 20-25 (2002) 21. Srivastava R., Ahmed H., Dixit R.K., Dharamveer, Saraf S.A.: Crocus sativus L.: A comprehensive review. Pharmacogn. Rev. 4: 200-208 (2010) 22. Carmona M., Zalacain A., Sánchez A.M., et. Al.: Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. J. Agric. Food Chem. 54: 973-979 (2006) 23. Tarantilis P.A., Tsoupras G., Polissiou M.: Deter-mination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry. J. Chromatogr. A. 699: 107-118 (1995) 24. Lozano P., Castellar M.R., Simancas M.J., Iborra J.L.: Quantitative highperformance liquid chromatographic method to analyse commercial saffron (Crocus sativus L.) products. J. Chromatogr. A. 830: 477-483 (1999) 25. Liakopulou-Kyriakides M., Kyriakides D.A.: Crocus sativus-Biological active Constituents. Stud. Nat. Prod. Chem. 26: 293-312 (2002) 26. Himeno H., Sano K.: Synthesis of crocin, picrocrocin and safranal by saffron stigma-like structures proliferated in vitro. Agric. Biol. Chem. 51: 2395-2400 (1987) 27. Castellar M.R., Montijano H., Manjón A., et. Preparative high performance liquid chromatography of saffron secondary metabolites. J. Chromatogr. 648: 187-190 (1993) 28. Tarantilis P.A., Polissiou M.: Isolation and identification of the aroma components from saffron (Crocus sativus L.). J. Agric. Food Chem. 45: 459-462 (1997) 29. Abe K., Saito H.: Effects of saffon and its constituent crocin on learning behavior and long-term potentiation. Phytother. Res. 14: 149-152 (2000) 30. Schmidt M., Betti G., Hensel A.: Saffron in phytotherapy: pharmacology and clinical uses. Wien Med. Wochen-schr. 157: 315-319 (2007) 31. Singh U.P., Singh D.P., Maurya S., et al.: Investigation on the phenolics of some spices having pharmacothera-peutic properties. J. Herb. Pharmacother. 4: 27-42 (2004) 32. Baumann B.B.: The botanical aspects of ancient Egyptian embalming and burial. Econ. Bot. 14: 84-104 (1960) 33. Potier P. and Chast F.: Το μαγαζάκι του καλού θεού. Εκδόσεις ψυχογιός, Αθήνα 2002 34. Abdullaev F.I.: Crocus sativus against cancer. Arch. Med. Res. 34: 354 (2003) 35. Akhondzadeh S., Tahmacebi-Pour N., Noorbala A.A., et al.: Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother. Res. 19: 148-151(2005) 36. Ferrence S.C., Bendersky G.: Therapy with saffron and the goddess at Thera. Perspect. Biol. Med. 47: 199-226 (2004) 37. Ríos J.L., Recio M.C., Giner R.M., Máñez S.: An update review of saffron and its active constituents. Phytother. Res. 10: 189-193 (1996) 38. Abdullaev F.I., Espinosa-Aguirre J.J.: Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect. Prev. 28: 426-432 (2004) 39. Hartwell J.L.; Plants used against cancer. A survey. Quaterman Publications. Lawrence, 1982, 284 40. Mathew B.: Crocus sativus and its allies (Iridaceae). Plant Syst. Evol. 128: 89-103 (1977) 41. Hosseinzadeh H., Nassiri-Asl M.: Avicenna’s (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother. Res. 27: 475-83 (2013) 42. Nair S.C., Pannikar B., Panikkar K.R.: Antitumour activity of saffron (Crocus sativus). Cancer Lett. 57: 109-114 (1991) 43. Aung H.H., Wang C.Z., Ni M., et al.: Crocin from Crocus sativus possesses significant antiproliferation effects on human colorectal cancer cells. Exp. Oncol. 29: 175-180 (2007) 44. Escribano J., Alonso G.L., Coca-Prados M., Fernandez J.A.: Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 100: 23-30 (1996) 45. Malaekeh-Nikouei B., Mousavi S.H., Shahsavand S., Mehri S., Nassirli H., Moallem S.A.: Assessment of cytotoxic properties of Safranal and Nanoliposomal Safranal in various cancer cell lines. Phytother. Res. 27(12): 1868-1873 (2013) 46. Chryssanthi D.G., Lamari F.N., Iatrou G., Pylara A., Karamanos N.K., Cordopatis P.: Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res. 27: 357-362 (2007) 47. Abdullaev F.I.: Biological effects of saffron. Biofactors 4: 83-86 (1993) 48. Martin G., Goh E., Neff A.W.: Evaluation of the developmental toxicity of crocetin on Xenopus. Food Chem. Toxicol. 40: 959-964 (2002) 49. Tarantilis P.A., Morjani H., Polissiou M., Manfait M.: Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L.: Anticancer Res. 14: 1913-1918 (1994) 50. Nair S.C., Kurumboor S.K., Hasegawa J.H.: Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10: 257-264 (1995) 51. Bhattacharjee B., Vijayasarathy S., Karunakar P., Chatterjee J.: Comparative reverse screening approach to identify potential antineoplastic targets of saffron functional components and binding mode. Asian Pac. J. Cancer Prev. 13: 5605-5611 (2012) 52. Zarei Jaliani H., Riazi G.H., Ghaffari S.M., Karima O., Rahmani A.: The effect of the crocus sativus L. Carotenoid, crocin, on the polymerization of microtubules, in vitro. Iran J. Basic Med. Sci. 16: 101-107 (2013) 53. Linardaki Z.I., Orkoula M.G., Kokkosis A.G., Lamari F.N., Margarity M.: Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment. Food Chem. Toxicol. 52: 163-170 (2013) 54. Vakili A., Einali M.R., Bandegi A.R.: Protective Effect of Crocin against Cerebral Ischemia in a Dose-Dependent Manner in a Rat Model of Ischemic Stroke. J. Stroke Cerebrovasc. Dis. 23: 106-113 (2014) 55. Hosseinzadeh H., Sadeghnia H.R.: Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J. Pharm. Pharm. Sci. 8: 394-399 (2005) 56. Pitsikas N., Zisopoulou S., Tarantilis P.A., Kanakis C.D., Polissiou M.G., Sakellaridis N.: Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats’ memory. Behav. Brain Res. 183: 141-146 (2007) 57. Sugiura M., Shoyama Y., Saito H., Nishiyama N.: Crocin improves the ethanol-induced impairment of learning behaviors of mice in passive avoidance tasks. Proceedings of Japanese Academy 71: 319-324 (1995) 58. Hosseinzadeh H., Ziaei T.: Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine induced learning deficits in rats performing the Morris water maze task. J. Med. Plants 5: 40-50 (2006) 59. Naghibi S.M., Hosseini M., et al.: Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment. Adv. Pharmacol. Sci. 2012: 494367, 2012 60. Hosseinzadeh H., Jahanian Z.: Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother. Res. 24: 726-730(2010) 61. Ahmad A.S., Ansari M.A., Ahmad M., et al.: Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol. Biochem. Behav. 81: 805-813 (2005) 62. Papandreou M.A., Kanakis C.D., et al.: Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J. Agric. Food Chem. 54: 8762-8768 (2006) 63. Hosseinzadeh H., Talebzadeh F.: Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitotherapia 76: 722-724 (2005) 64. Hosseinzadeh H., Sadeghnia H.R.: Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 14: 256-262 (2007) 65. Akhondzadeh S., Fallah-Pour H., Afkham K., Jamshidi A.H., Khalighi-Cigaroudi F.: Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial. BMC Complement. Altern, Med. 4: 12 (2004) 66. Noorbala A.A., Akhondzadeh S., Tahmacebi-Pour N., Jamshidi A.H.: Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J. Ethnopharmacol. 97: 281-284 (2005) 67. Hosseinzadeh H., Karimi G., Niapoor M.: Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Acta Hortic 650: 435-445 (2004) 68. Lechtenberg M., Schepmann D., Niehues M., Hellenbrand N., Wünsch B., Hensel A.: Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 receptors. Planta Med. 74: 764-772 (2008) 69. Pittenger C. Sanacora G., Krystal J.H.: The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neuro. Disord. Drug Targets 6: 101-115 (2007) 70. Georgiadou G., Tarantilis P.A., Pitsikas N.: Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder. Neurosci. Lett. 528: 27-30 (2012) 71. Pitsikas N., Boultadakis A., Gergiadou G., Tarantilis P.A., Sakellaridis N.: Effects of the active constituents of Crocus sativus L. in an animal model of anxiety. Phyto-medicine 15: 1135-1139 (2008) 72. Hosseinzadeh H., Ziaee T., Sadeghi A.: The effect of saffron, Crocus sativus stigma extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 15: 491-495 (2008) 73. Kashani L., Raisi F., Saroukhani S., et al.: Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum. Psychopharmacol. 28: 54-60 (2013) 74. Modabbernia A., Sohrabi H., Nasehi A.A., et al.: Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psycho-pharmacology (Berl) 223: 381-388 (2012) 75. Heidary M., Vahhabi S., Reza Nejadi J., et al.: Effect of saffron on semen parameters of infertile men. Urol. J. 5: 255-259 (2008) 76. Shamsa A., Hosseinzadeh H., Molaei M., et. al.: Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine 16: 690-693 (2009) 77. Agha-Hosseini M., Kashani L., Aleyaseen A., et al.: Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG 115: 515-519 (2008) 78. Fukui H., Toyoshima K., Komaki R.: Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine 18: 726-730 (2011) 79. Zeinali F., Anvari M., Dashti R.M.H., Hosseini S.M.: The effects of different concentrations of saffron (Crocus sativus) decoction on preterm delivery in mice. Planta Med. 75-PI29 (2009) 80. Yang X.G., Zhang Q., Yu J.N., Lian J.P., Lei A.J.: Effect of Crocus sativus extract on the concentration of glutamic acid in the vitreous body in rabbits with chronic ocular hypertension. Int. J. Ophthalmol. 6: 1025-1026 (2006) 81. Martínez-Tomé M., Jiménez A.M., Ruggieri S., Frega N., Strabbioli R., Murcia M.A.: Antioxidant properties of Mediterranean spices compared with common food additives. J. Food Prot. 64: 1412-1419 (2001) 82. Assimopoulou A.N., Sinakos Z., Papageorgiou V.P.: Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother. Res. 19: 997-1000 (2005) 83. Kanakis C.D., Tarantilis P.A., Tajmir-Riahi H.A., Polissiou M.G.: Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties. J. Agric. Food Chem. 55: 970-977 (2007) 84. Premkumar K., Abraham S.K., Santhiya S.T., Ramesh A.: Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother. Res. 17: 614-617 (2003) 85. Naghizadeh B., Boroushaki M.T., Vahdati M.N., Mansouri M.T.: Protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rats. Iran Biomed. J. 12: 93-100 (2008) 86. Tseng T.H., Chu C.Y., Huang J.M., Shiow S.J., Wang C.J.: Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 97: 61-67 (1995) 87. Xu G.L., Qian Z.Y., Yu S.Q., et al.: Evidence of crocin against endothelial injury induced by hydrogen peroxide in vitro. J. Asian Nat. Prod. Res. 8: 79-85 (2006) 88. Hosseinzadeh H., Shamsaie F., Mehri S.: Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents, crocin and safranal. Phcog Mag. 5: 419-424 (2009) 89. Asdaq S.M., Inamdar M.N.: Potential of Crocus sativus (saffron) and its Constituent, Crocin, as Hypolipidemic and Antioxidant in Rats. Appl. Biochem. Biotechnol.162: 358-372 (2010) 90. Ochiai T., Ohno S., Soeda S., Tanaka H., et al.: Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci. Lett. 362: 61-64 (2004) 91. Papandreou M.A., Tsachaki M., Efthimiopoulos S., Cordopatis P., Lamari F.N., Margarity M.: Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behav. Brain Res. 219: 197-204 (2011) 92. Sadeghnia H.R., Kamkar M., Assadpour E., Boroushaki M.T., Ghorbani A.: Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus. Iran J. Basic Med. Sci. 16: 73-82 (2013) 93. Verma S.K., Bordia A.: Antioxidant property of Saffron in man. Indian J. Med. Sci. 52: 205-207 (1998) |
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