Τόμος 33 (2015) – Τεύχος 3 – Άρθρο 9 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 33 (2015) – Issue 3 – Article 9 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title
Η συμβολή του περιβάλλοντος στην παθογένεια της ακμής

The Contribution of the Environment on the Pathogenesis of Acne

Συγγραφέας – Author

Μαρία Χ. Μαζιώτη

Ιατρός, MD, PhD, Διδάκτωρ Ιατρικής Σχολής Πανεπιστημίου Αθηνών, Αθήνα, Ελλάς

Maria Mazioti

MD, PhD, Medical School, National and Kapodistrian University of Athens, Athens, Hellas

Παραπομπή – Citation
Μαζιώτη,Μ. : Η συμβολή του περιβάλλοντος στην παθογένεια της ακμής, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 33: 281-291 (2015)
Mazioti,M. : The Contribution of the Environment on the Pathogenesis of Acne, Epitheorese Klin. Farmakol. Farmakokinet. 33: 281-291 (2015)
Ημερομηνία Δημοσιευσης – Publication Date
3 Σεπτεμβρίου 2015 – 2015-09-03
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords
Ακμή, περιβάλλον, διατροφή, ρύπανση
Acne, environment, diet, pollution
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary
Η ακμή αποτελεί ένα κοινωνικό και οικονομικό πρόβλημα υγείας. Νεότερα επιδημιολογικά δεδομένα υποστηρίζουν πως η ακμή εμφανίζεται σε ένα σημαντικό ποσοστό ενήλικων  ατόμων και πως η επίπτωσή της είναι ιδιαίτερα υψηλή στις βιομηχανοποιημένες κοινωνίες, λόγω της επίδρασης διαφόρων περιβαλλοντικών παραμέτρων. Το παρόν άρθρο αποτελεί βιβλιογραφική ανασκόπηση και καταγραφή των δεδομένων που εστιάζονται στην επίδραση της διατροφής, της ατμοσφαιρικής μόλυνσης, της ρύπανσης εσωτερικών χώρων, της υπεριώδους ακτινοβολίας, του κλίματος, του συναισθηματικού στρες και της χρήσης καλλυντικών προϊόντων και φαρμάκων στην εμφάνιση της ακμής. Δεδομένου ότι οι παθογενετικοί μηχανισμοί της νόσου δεν έχουν πλήρως διευκρινιστεί, είναι πιθανόν η ταυτόχρονη έκθεση του ατόμου στους ανωτέρω περιβαλλοντικούς παράγοντες, σε συνδυασμό με την επίδραση και άλλων παραμέτρων, να συμβάλουν στην εμφάνιση, την επιδείνωση και στη διαιώνιση της ακμής.

Acne constitutes a major health, social and economic problem. Current epidemiological evidence suggests that acne affects a significant proportion of the adult population and its prevalence is considerably higher in industrialized societies due to the influence of environmental factors. The present article is a systematic review of the available data about the contribution of diet, air and indoor pollution, ultraviolet radiation, climate, emotional stress, cosmetics and drugs in acne. Since the pathways underlying the pathogenesis of acne are still being elucidated, the simultaneous exposure to these environmental agents may be key determinants which in combination with other etiological factors induce the initiation, aggravation and perpetuation of acne.

Αναφορές – References1
1. Zouboulis C.C., Eady A., Philpott M., et al.: What is the pathogenesis of acne? Exp. Dermatol. 14: 143-152 (2005)

2. Oberemok S.S., Shalita A.R.: Acne vulgaris, I: pathogenesis and diagnosis. Cutis 70: 101-105 (2002)

3. Cordain L., Lindeberg S., Hurtado M., Hill K., Eaton S.B., Brand-Miller J.: Acne vulgaris: a disease of Western civilization. Arch. Dermatol. 138: 1584-1590 (2002)

4. Fitzpatrick R.J., Wolff K., Suurmond D. (Eds): Κλινική Δερματολογία. Τόμος Ι, σελ. 1-7, Ιατρικές εκδόσεις Π.Χ. Πασχαλίδης. Αθήνα, 2002

5. Cunliffe W.J., Cotterill J.A. (EDs): The acnes: Clinical features, pathogenesis and treatment. Book: Major problems in Dermatology. Pag. 13-14, Philadelphia Pa,W.B. Saunders and Co, 1975

6. Δεσινιώτη Κ., Κατσάμπας Α.: Ο ρόλος της δίαιτας στην ακμή: Νεώτερα δεδομένα. Ελληνική Επιθεώρηση Δερματολογίας Αφροδισιολογίας 18:187-193 (2007)

7. Bechelli L.M., Haddad N., Pimenta W.P., et al. Epidemiological survey of skin diseases in schoolchildren living in the Purus Valley (Acre State, Amazonia, Brazil). Dermatologica 163: 78-93 (1981)

8. Wolf R,, Matz H,, Orion E.: Acne and diet. Clin. Dermatol. 22: 387-393 (2004)

9. Smith T.M., Cong Z., Gilliland K.L., Clawson G.A., Thiboutot D.M.: Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J. Invest. Dermatol. 126: 1226-1232 (2006)

10. Χρυσικόπουλος Α.: Ο μικρόκοσμος της αναπαραγωγικής διαδικασίας. Αυξητικοί παράγοντες και κυταροκίνες. Έκδοση Ελληνικής Εταιρείας Γυναικολογικής Ενδοκρινολογίας 12: 25-33 (2000)

11. Rager K.M., Omar H.A.: Androgen excess disorders in women: the severe insulin-resistant hyperandrogenic syndrome. HAIR-AN. Sci. World J. 6: 116-121 (2006)

12. Smith K.R., Thiboutot D.M.: Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe? J. Lipid Res. 49: 271-281 (2008)

13. Brismar K., Fernqvist-Forbes E., Wahren J., Hall K.: Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J. Clin. Endocrinol. Metab. 79: 872-878 (1994)

14. Melnik B.C., Schmitz G.: Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp. Dermatol. 18: 833-841 (2009)

15. Liu B., Lee H.Y., Weinzimer S.A., et al.: Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. J. Biol. Chem. 275: 33607-33613 (2000)

16. Smith R.N., Mann N.J., Braue A., Makelainen H., Varigos G.A.: A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am. J. Clin. Nutr. 86(1): 107-115 (2007)

17. Taylor A.E.: Insulin-lowering medications in polycystic ovary syndrome. Obstet. Gynecol. Clin. North Am. 27: 583-595 (2000)

18. Harborne L., Fleming R., Lyall H., Norman J., Sattar N.: Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome. Lancet 361: 1894-1901 (2003)

19. Pasquali R., Filicori M.: Insulin sensitizing agents and polycystic ovary syndrome. Eur. J. Endocrinol. 138: 253-254 (1998)

20. Denburg M.R., Silfen M.E., Manibo A.M., et al.: Insulin sensitivity and the insulin-like growth factor system in prepubertal boys with premature adrenarche. J. Clin. Endocrinol. Metab. 87: 5604-5609 (2002)

21. Adebamowo C.A., Spiegelman D., Danby F.W., Frazier A.L., Willett W.C., Holmes M.D.: High school dietary dairy intake and teenage acne. J. Am. Acad. Dermatol. 52: 207-214 (2005)

22. Darling J.A., Laing A.H., Harkness R.A.: A survey of the steroids in cows’ milk. J. Endocrinol. 62: 291-297 (1974)

23. Melnik B.C.: Milk – The promoter of chronic Western diseases. Medical hypotheses 72: 631-639 (2009)

24. Foster-Powell K., Holt S.H., Brand-Miller J.C.: International table of glycemic index and glycemic load values: 2002. Am. J. Clin. Nutr. 76(1): 5-56 (2002)

25. Klinge F Wacker L. Ueber den lipoidstoffwechsel und di gewebsveraenderungen bei mausen und kaninchen unter dem einfluss von fett, cholesterin, und scharlachrotfutterung. Krankheitsforschung 1: 257-285 (1925)

26. Somekawa E.: On the production of seborrhea in the rat by feeding with whale oil. Sci. Papers Inst. Phys. Chem. Res. 42: 72-79 (1947)

27. Suzuki S.: Zur physiologie und pathologie der talgsekretion, besonders by lues. Jpn J. Derm. Unol. 40: 203-13 (1936)

28. Pochi P.E., Downing D.T., Strauss J.S.: Sebaceous gland response in man to prolonged total caloric deprivation. J. Invest. Dermatol. 55: 303-309 (1970)

29. Downing D.T., Strauss J.S., Pochi P.E.: Changes in skin surface lipid composition induced by severe caloric restriction in man. Am. J. Clin. Nutr. 25: 365-367 (1972)

30. MacDonald I.: Effects of a skimmed milk and chocolate diet on serum and skin lipids. J. Sci. Food Agr. 19: 270-272 (1968)

31. Ebling F., Cunliffe W. (Eds): Disorders of the sebaceous glands. Champion R., Butron J., Ebling F., editors Rook/Wilkinson/Ebling textbook of dermatology Oxford, UK: Blackwell Scientific, 1699-1744, 1992

32. Downing D S.M., Wertz P., et al. (Eds): Lipids of the epidermis and the sebaceous glands. Fitzpatrick T.,.Eisen A., Wolff K., et al, editors: Dermatology in general medicine New York: McGraw-Hill, 210-221, 1993

33. Pappas A., Anthonavage M., Gordon J.S.: Metabolic fate and selective utilization of major fatty acids in human sebaceous gland. J. Invest. Dermatol. 118: 164-171 (2002)

34. Cordain L.: Implications for the role of diet in acne. Semin. Cutan. Med. Surg. 24: 84-91 (2005)

35. Spencer E.H., Ferdowsian H.R., Barnard N.D.: Diet and acne: a review of the evidence. Intern. J. Dermatol. 48: 339-347 (2009)

36. Hitch J.M., Greenburg B.G.: Adolescent acne and dietary iodine. Arch. Dermatol. 84: 898-911 (1961)

37. Rubin M.G., Kim K., Logan A.C.: Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids Health Dis. 7: 36 (2008)

38. Stocker R., Keaney J.F.,Jr.: Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84: 1381-1478 (2004)

39. Bowe W.P., Joshi S.S., Shalita A.R.: Diet and acne. J. Am. Acad. Dermatol. 63: 124-141 (2010)

40. Michaelsson G., Edqvist L.E.: Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Dermatovenere-ologica 64: 9-14 (1984)

41. Tsukada M., Schroder M., Roos T.C., et al.: 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J. Invest. Dermatol. 115: 321-327 (2000)

42. Tom W.L., Barrio V.R.: New insights into adolescent acne. Curr. Opin. Pediatr. 20: 436-440 (2008)

43. Bowe W.P., Shalita A.R.: Effective over-the-counter acne treatments. Semin. Cutan. Med. Surg. 27: 170-176 (2008)

44. Amer M., Bahgat M.R., Tosson Z., Abdel Mowla M.Y., Amer K.: Serum zinc in acne vulgaris. Inter. J. Dermatol. 21: 481-484 (1982)

45. Michaelsson G., Vahlquist A., Juhlin L.: Serum zinc and retinol-binding protein in acne. Br. J, Dermatol. 96(5): 283-286 (1977)

46. Dreno B., Moyse D., Alirezai M., et al.: Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology 203:135-140 (2001)

47. Kaufman W.H.: The diet and acne. Arch. Dermatol. 119: 276 (1983)

48. Halvorsen J.A., Dalgard F., Thoresen M., Bjertness E., Lien L.: Is the association between acne and mental distress influenced by diet? Results from a cross-sectional population study among 3775 late adolescents in Oslo, Norway. BMC Public Health 9: 340 (2009)

49. Freyre E.A., Rebaza R.M., Sami D.A., Lozada C.P.: The prevalence of facial acne in Peruvian adolescents and its relation to their ethnicity. J. Adolesc. Health 22: 480-484 (1998)

50. Μαυρογιάννη X., Ιατρίδη Β.: Ακμή και διατροφή: Μύθοι και αλήθειες. Ελληνική Επιθεώρηση Διαιτολογίας-Διατροφής 1: 87-99 (2010)

51. Bett D.G., Morland J., Yudkin J.: Sugar consumption in acne vulgaris and seborrhoeic dermatitis. Br. Med. J. 3: 153-155 (1967)

52. Fulton J.E.,Jr., Plewig G., Kligman A.M.: Effect of chocolate on acne vulgaris. JAMA 210: 2071-2074 (1969)

53. Anderson P.C.: Foods as the cause of acne. Am. Fam. Physician 3(3): 102-3 (1971)

54. Grant J.D., Anderson P.C.: Chocolate as a cause of acne: A dissenting view. Mo Med. 62: 459-460 (1965)

55. Schecter A., Birnbaum L., Ryan J.J., Constable J.D.: Dioxins: an overview. Environ. Res. 101: 419-428 (2006)

56. Environmental Protection Agency (EPA) Eahhro, 3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related com-pounds: National Academy of Sciences (NAS) review draft. (2005)

57. Suskind R.R.: Chloracne, the hallmark of dioxin intoxication. Scand. J. Work Environ. Health 11: 165-171 (1985)

58. Herxheimer K.: Uber Chloraknel (Chloracne). Muench. Med. Wochenschr. 1: 46 (1899)

59. Mocarelli P., Needham L.L., Marocchi A., et al.: Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy. J. Toxicol. Environ. Health 32: 357-366 (1991)

60. Coenraads P.J., Olie K., Tang N.J.: Blood lipid concentrations of dioxins and dibenzofurans causing chloracne. Br. J. Dermatol. 141: 694-697 (1999)

61. Burton J.E., Michalek J.E., Rahe A.J.: Serum dioxin, chloracne, and acne in veterans of Operation Ranch Hand. Arch. Environ. Health 53: 199-204 (1998)

62. World Health Organisation: Indoor air pollutants iaea Iran, working group report, Nordlinger, Copenhagen, 1982

63. Kjrgaard S., Molhave L., Pedersen O.: Human reactions to a mixture of indoor air volatileorganic compounds. Atmospheric Environ. 25: 1417-1426 (1991)

64. Carmines E.L.: Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 40:77-91 (2002)

65. Misery L.: Nicotine effects on skin: are they positive or negative? Exp. Dermatol. 13: 665-670 (2004)

66. Grando S.A., Horton R.M., Pereira E.F., et al.: A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J. Invest. Dermatol. 105: 774-781 (1995)

67. Grando S.A., Zelickson B.D., Kist D.A., et al.: Keratinocyte muscarinic acetylcholine receptors: immunolocalization and partial characterization. J. Invest. Dermatol. 104: 95-100 (1995)

68. Burczynski M.E., Lin H.K., Penning T.M.: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 59: 607-614 (1999)

69. Capitanio B., Sinagra J.L., Ottaviani M., Bordignon V., Amantea A., Picardo M.: Smoker’s acne: a new clinical entity? Br. J. Dermatol. 157: 1070-1071 (2007)

70. Ottaviani M., Alestas T., Flori E., Mastrofrancesco A., Zouboulis C.C., Picardo M.: Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. J. Invest. Derma-tol. 126: 2430-7 (2006)

71. Tsuji G., Takahara M., Uchi H., et al.: An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. J. Dermatol. Sci. 62: 42-49 (2011)

72. Firooz A., Sarhangnejad R., Davoudi S.M., Nassiri-Kashani M: Acne and smoking: is there a relationship? BMC Dermatol. 5: 2 (2005)

73. Klaz I., Kokhba I., IShohat T., Zarka S., Brenner S.: Severe acne vulgaris and tobacco smoking in young men. J. Invest. Dermatol. 126: 1749-1752 (2006)

74. Sarasin A.: The molecular pathways of ultraviolet-induced carcinogenesis. Mutat. Res. 428: 5-10 (1999)

75. Kelly G.E., Meikle W.D., Moore D.E.: Enhancement of UV-induced skin carcinogenesis by azathioprine: role of photochemical sensitisation. Photochem. Photobiol. 49: 59-65 (1989)

76. Picardo M., Zompetta C., De Luca et al.,: Squalene peroxides may contribute to ultraviolet light-induced immunological effects. Photodermatol. Photoimmunol. Photomed. 8: 105-10 (1991)

77. Kohno Y., Sakamo O., Nakamura T., Miyazawa T.: Determination of human skin surface lipid peroxides by chemiluminescence-HPLC. J. Japan Oil Chem. Soc. 40: 715-718 (1993)

78. Saint-Leger D., Bague A., Cohen E., Chivot M.: A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation. Br. J. Dermatol. 114: 535-542 (1986)

79. Ottaviani M., Camera E., Picardo M.: Lipid mediators in acne. Mediators Inflamm.: 858176 (2010)

80. Motoyoshi K.: Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides. Br. J. Dermatol. 109: 191-8 (1983)

81. Picardo M., Ottaviani M., Camera E., Mastrofrancesco A.: Sebaceous gland lipids. Dermatoendocrinology 1: 68-71 (2009)

82. Mills O.H., Kligman A.M.: Ultraviolet phototherapy and photochemotherapy of acne vulgaris. Arch. Dermatol. 114: 221-223 (1978)

83. Papageorgiou P., Katsampas A., Chu A.: Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br. J. Dermatol. 142: 973-978 (2000)

84. Ammad S., Gonzalez M., Mills C.M.: The effect of blue light phototherapy on mild to moderate acne. Br. J. Dermatol. 147(Suppl 62): 95 (2002)

85. Kawada A.A.Y., Kameyama H., Sangen Y., Tezuka T.: Acne phototherapy with a high-intensity, enhanced, narrow-band, blue light source: an open study and in vitro investigation. J. Dermat. Sci 30: 129-135 (2002)

86. Magin P., Pond D., Smith W., Watson A.: A systematic review of the evidence for ‘myths and misconceptions’ in acne management: diet, face-washing and sunlight. Family Practice 22: 62-70 (2005)

87. Horne G.O.: Climatic environmental factors in the etiology of skin diseases. J. Invest. Dermatol. 1: 107-112 (1950)

88. Al-Ameer A.M., Al-Akloby O.M.: Demographic features and seasonal variations in patients with acne vulgaris in Saudi Arabia: a hospital-based study. Int. J. Dermatol. 41: 870-871 (2002)

89. Gfesser M., Worret W.I.: Seasonal variations in the severity of acne vulgaris. Int. J. Dermatol. 35: 116-117 (1996)

90. White G.M.: Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J. Am. Acad. Dermatol. 39: S34-37 (1998)

91. Marks R.: Acne-social impact and health education. J. Royal Soc. Med. 78: 21-24 (1985)

92. James C.W. (Ed.) Topics in Topicals. Ed R. Marks MTP Press, Lancaster 11-22, 1985

93. Kligman A.M., Mills O.H.,Jr.: Acne cosmetica. Arch. Dermatol. 106: 843-850 (1972)

94. Knaggs H.E., Wood E.J., Rizer R.L., Mills O.H.: Postadolescent acne. Int. J. Cosm. Sci. 26: 129-138 (2004)

95. Williams C., Layton A.M.: Persistent acne in women: Implications for the patient and for therapy. Am. J. Clin. Dermatol. 7: 281-290 (2006)

96. Saunders M.A.: Letter: Fluoride toothpastes: a cause of acne-like eruptions. Arch. Dermatol. 111: 793 (1975)

97. Valeyrie-Allanore L., Sassolas B., Roujeau J.C.: Drug-induced skin, nail and hair disorders. Drug Saf. 30: 1011-1030 (2007)

98. Aktan S., Ozmen E., Sanli B.: Anxiety, depression, and nature of acne vulgaris in adolescents. Int. J. Dermatol. 39: 354-357 (2000)

99. Rasmussen J.E., Smith S.B.: Patient concepts and misconceptions about acne. Arch. Dermatol. 119: 570-572 (1983)

100. Green J., Sinclair R.D.: Perceptions of acne vulgaris in final year medical student written examination answers. Australia J. Dermatol. 42: 98-101 (2001)

101. Yosipovitch G., Tang M., Dawn A.G., et al.: Study of psychological stress, sebum production and acne vulgaris in adolescents. Acta Derm. Venereol. (Stockh) 87: 135-139 (2007)

102. Habib K.E., Gold P.W., Chrousos G.P.: Neuroendocrinology of stress. Endocrinol. Metab. Clin. North America 30: 695-728 (2001)

103. Slominski A., Wortsman J., Luger T., Paus R., Solo-mon S.: Corticotropin releasing hormone and proopiomela-nocortin involvement in the cutaneous response to stress. Physiol. Rev. 80: 979-1020 (2000)

104. Zouboulis C.C., Bohm M.: Neuroendocrine regulation of sebocytes: a pathogenetic link between stress and acne. Exp. Dermatol. 13: 31-35 (2004)

105. Zouboulis C.C., Seltmann H., Hiroi N, et al.: Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc. Natl. Acad. Sci. USA 99: 7148-7153 (2002)

106. Fitzgerald M.: Capsaicin and sensory neurones – a review. Pain 15:109-130 (1983)

107. Maggi C.A., Meli A.: The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen. Pharmac. 19: 1-43 (1988)

108. Lee W.J., Jung H.D., Lee H.J., Kim B.S., Lee S.J., Kim do W.: Influence of substance-P on cultured sebocytes. Arch. Dermatol. Res. 300: 311-316 (2008)

109. Ganceviciene R., Graziene V., Bohm M., Zouboulis C.C.: Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. Exp. Dermatol. 16: 547-552 (2007)

110. Garg A., Chren M.M., Sands L.P., et al.: Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch. Dermatol. 137: 53-59 (2001)

111. Denda M., Tsuchiya T., Hosoi J., Koyama J.: Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin. Br. J. Dermatol. 138: 780-785 (1998)

 

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