Τίτλος – Title
|
Μηχανισμοί Χημειοπροφύλαξης στον Καρκίνο
|
|
Συγγραφέας – Author
|
Χαριτίνη Νέπκα1, Δημήτρης Κουρέτας2 1 Κυτταρολογικό Εργαστήριο, Σέρρες, Ελλάς 2 Τμήμα Γεωπονίας, Πανεπιστήμιο Θεσσαλίας, Βόλος, Ελλάς Ch. Nepka, D. Kouretas Laboratory of Animal Physiology, School of Agriculture, University of Thessaly, Pedion Areos, Volos, Greece |
|
Παραπομπή – Citation
|
Νέπκα,Χ., Κουρέτας,Δ. : Μηχανισμοί Χημειοπροφύλαξης στον Καρκίνο , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 17 : 121-128 (1999) Nepka,Ch., Kouretas,D. : Mechanisms of Chemoprevention in Cancer, Epitheorese Klin. Farmakol. Farmakokinet. 17: 121-128 (1999) |
|
Ημερομηνία Δημοσιευσης – Publication Date
|
10-09-1999
|
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
|
Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
|
Λέξεις κλειδιά – Keywords
|
Καρκίνος, χημειοπροφύλαξη, μηχανισμοί Cancer, chemoprevention, mechanisms
|
|
Λοιποί Όροι – Other Terms
|
Άρθρο Article |
|
Περίληψη – Summary
|
Στο άρθρο αυτό ανασκοπούνται οι σύγχρονες απόψεις που αφορούν στους μηχανισμούς δράσης των χημειοπροφυλακτικών για τον καρκίνο ουσιών. Ο όρος χημειοπροφύλαξη χρησιμοποιείται για να περιγράψει την πρόληψη, αναστολή ή αντιστροφή της καρκινογενετικής διαδικασίας με τη χορήγηση ενός ή περισσότερων χημικών ουσιών με τη μορφή φαρμάκων ή με τα φυσικά συστατικά των τροφών. Οι χημειοπροφυλακτικές ουσίες, ανάλογα με τη χρονική περίοδο που εμφανίζουν τη δράση τους σε πειραματικά μοντέλα καρκινογένεσης στα πειραματόζωα μπορεί να ταξινομηθούν σε 3 κατηγορίες: στους αναστολείς του σχηματισμού καρκινογόνου, σε παράγοντες παρεμπόδισης της δράσης του καρκινογόνου κατά την πρώτη φάση της καρκινογένεσης και σε παράγοντες καταστολής της νεοπλασματικής ανάπτυξης με δράση κατά την προαγωγική ή εξελικτική φάση της καρκινογένεσης. Αρκετοί ωστόσο χημειοπροφυλακτικοί παράγοντες φαίνεται να δρουν μέσω περισσότερων από ένα μηχανισμών, γεγονός που δυσκολεύει την κατάταξή τους σύμφωνα με τον περισσότερο δραστικό μηχανισμό. Η συζήτηση επάνω στους βασικούς μηχανισμούς δράσης των χημειοπροφυλακτικών ουσιών συνοδεύεται από συγκεκριμένα παραδείγματα. Ο πλήρης κατάλογος των μέχρι σήμερα γνωστών χημειοπροφυλακτικών ουσιών εκφεύγει του σκοπού του άρθρου αυτού. The mechanisms through which cancer chemoprevention agents inhibit carcinogenesis are reviewed. Cancer chemoprevention can be defined as prevention, inhibition or reversal of carcinogenesis by administration of one or more chemical compounds, either as substances given as a medication formula or prophylactic therapy, or as naturally occurring constituents of the diet. According to the time period that chemoprevention agents exert their activity in animal models, they can be classified into three classes: Inhibitors of carcinogen formation, blocking agents with action in the initiation phase of carcinogenesis (inhibitors of expression of phase I enzymes, inducers of phase II enzymes, free radical scavengers, etc) and tumor suppressing agents with inhibitory action in the promotion/progression phase of carcinogenesis (inducers of cell death, regulators of steroid hormone action, regulators of signal transduction pathways, etc). Many chemopreventive agents act through more than one mechanism, making it difficult to classify them according to the most effective mode of action. Examples of various agents that act through these mechanisms are presented. |
|
Αναφορές – References
|
1. Morse M.A., Stoner G.C.: Cancer chemoprevention: principles and prospects. Carcinogenesis 14: 1737-1746 (1993)
2. Kelloff G.J., Boone C.W., Steele V.E., et al. : Progress in cancer chemoprevention: perspectives on agent selection and short term clinical intervention trials. Cancer Res. 54: 2015-2024 (1994) 3. Greenwald ., Kelloff G., Burch Whitman C., Kramer B.S.: Chemoprevention CA. Cancer J. Clin. 45: 31-49 (1995) 4. ACS. Cancer Facts and Figures. GA: American Cancer Society, 1-3, Atlanta, 1995 5. Wattenberg L.W.: Chemoprevention of cancer. Cancer Res. 45: 1-8 (1985) 6. Mirvish S.S.: Ascorbic acid inhibition of N-nitroso compound formation in chemical, food and biological systems. In: Inhibition of Tumor Induction and Development (Zedeck M.S., Lipkin M., eds). Pp. 101-126, Plenum, New York, 1981 7. Hartman P.E., Shankel D.M.: Antimutagens and anti-carcinogens: a survey of putative interceptor molecules. Environ. Mol. Mutagen. 15: 145-182 (1990) 8. Kuenzig W., Chau J., Norkus E., et al.: Caffeic acid and ferulic acid as blockers of nitrosamine formation. Carcinogenesis 5: 309-314 (1984) 9. Shenoy N.R., Choughuley A.S.U.: Inhibitory effect of diet related sulfydryl compounds on the formation of carcinogenic nitrosamines. Cancer Lett. 65: 227-232 (1992) 10. Miller E.C., Miller J.A.: Some historical perspectives on the metabolism of xenobiotic chemicals to reactive electrophils. In: Bioactivation of Foreign Compounds (Anders M.W., ed.). Pp. 1-28, Academic Press, New York, 1985 11. Conney A.H.: Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: GHA Clowes Memorial Lecture. Cancer Res. 42: 4875-4917 (1982) 12. Morse M.A., Eklind K.I., Hecht S.S., et al.: Structure activity relationships for inhibition of 4-methylnitrosamino-1-3(pyridyl)-1-dutanone (NNK) lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 51: 1846-1850 (1991) 13. Stoner G.D., Siglin J.C., Morse M.A., et al., Francis D.J.: Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenyl hexyl isothiocyanate. Carcinogenesis 16: 2473-2476 (1995) 14. Wattenberg L.W., Loub W.D.: Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res. 38: 1410-1413 (1978) 15. Tanaka T., Mori Y., Morishita Y., et al.: Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine induced hepatocarcinogenesis in male ACI/N rats. Carcinogenesis 10: 175-181 (1990) 16. Pence B.C., Buddingh F., Yang S.P.: Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. J. Natl. Cancer Inst. 77: 269-276 (1986) 17. Bailey G.S., Hendricks J.D., Shelton D.W., et al.: Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol. J. Natl. Cancer Inst. 78: 931-934 (1987) 18. Zhang Y., Talalay P., Cho C.-G., Posner G.H.: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89: 2399-2403 (1992) 19. Zhang Y., Kensler T.W., Cho C.-G., et al.: Anticarcinogenic activities of sulforaphane and structurally related synthetic norbonyl isothiocyanates. Proc. Natl. Acad. Sci. USA 91: 3147-3150 (1994) 20. Roebuck B.D., Liu Y.-L., Rogers A.E., et al.: Protection against aflatoxin B1 induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz): predictive role of molecular dosimetry. Cancer Res. 51: 5501-5506 (1991) 21. Sayer J.M., Yagi H., Wood A.W., et al.: Extremely facile reaction between the ultimate carcinogen benzo[a]pyrene-7,8-diol-9,10epoxide and ellagic acid. J. Am. Chem. Soc. 104: 5562-5564 (1982) 22. Packer J.E., Mahood J.S., Mora-Arellano V.O., et al.: Free radicals and singlet oxygen scavengers: reaction of a peroxy radical with beta-carotene, diphenyl furan and 1,4-diazobicyclo (2,2,2)-octane. Biochem. Biophys. Res. Commun. 98: 901-906 (1981) 23. Kensler T.W., Trush M.A., Guyton K.Z.: Free radicals as targets for cancer chemoprevention: prospects and problems. In: Cellular and Molecular Targets for Chemoprevention (Steele V.H., Stoner G.D., Boone C.W., Kelloff G.J., eds). Pp. 173-191, CRC Press, Boca Raton, FL, 1992 24. Imanishi H., Sakaki Y.F., Matsumoto K., et al.: Suppression of 6-TG- resistant mutations in V79 cells and recessive spot formations in mice by vanillin. Mutat. Res. 243: 151-158 (1990) 25. Farzaneh F., Panayotou G.N., Bowler L.D., et al.: ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome. Nucleic Acid Res. 16: 1319-1326 (1988) 26. Cesarone C.F., Scovassi A.I., Scarabelli L., et al.: Depletion of adenosine diphosphate-ribosyl transferase activity in rat liver during exposure to N-2-acetylaminofluorene: effect of thiols. Cancer Res. 48: 3581-3585 (1988) 27. Meyn S.M., Rossman T., Troll W.A.: A protease inhibitor blocks SOS functions in Escherichia Coli: Antipain prevents lambda repressor inactivation, ultraviolet mutagenesis and filamentous growth. Proc. Natl. Acad. Sci. USA 74: 1152-1156 (1977) 28. De Flora S., Ramel C.: Classification of mechanisms of inhibitors of mutagenesis and carcinogenesis. Basic Life Sci. 52: 461-462 (1990) 29. Kelloff G.J., Boone C.W., Steele V.E., et al.: Mechanistic considerations in chemopreventive drug development. J. Cell. Biochem. (Suppl.) 20: 1024 (1994) 30. Pegg A.E.: Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 48: 759-774 (1988) 31. Slaga T.J.: Overview of tumor promotion in animals. Environ. Health. Perspect. 50: 3-14 (1983) 32. Thompson H.J., Ronan A.M.: Inhibition of 1-methyl-1-nitrosourea induced mammary tumorigenesis by a-difluoromethylornithine and retinyl acetate. Proc. Am. Assoc. Cancer Res. 24: 86 (1983) 33. Whitfield J.F.: Calcium: driver of cell cycles, trigger of differentiation, and killer of cells. In: Cellular and Molecular Targets for Chemoprevention (Steele V.E., Stoner G.D., Boone C.W., Kelloff G.J., eds). Pp. 257-311: CRC Press, Boca Raton FL, 1992 34. Huang F.L., Roop D.R., De Luca L.M.: Vitamin A deficiency and keratin biosynthesis in cultured hamster trachea. In Vitro Cell Dev. Biol. 22: 223 (1986) 35. Sani B.P., Singh R.K., Reddy L.G., Gaub M.-P.: Isolation, partial purification and characterization of nuclear retinoid acid receptors from chick skin. Arch. Biochem. Biophys. 283: 107-113 (1990) 36. Kelloff G.J., Boone C.W., Steele V.E., et al.: Inhibition of chemical carcinogenesis. In: Chemical Induction of Cancer: Modulation and Combination Effects (Arcos J., Argus M., Woo Y., eds). Birkhauser Boston, 1997 37. Roberts A.B., Sporn M.B.: Transforming growth factor β. Adv. Cancer Res. 51: 107-145 (1988) 38. Jordan V.C.: The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 70: 977-982 (1992) 39. Elson C.E., Maltzman T.H., Boston J.L., et al.: Anti-carcinogenic activity of D-limonene during the initiation and promotion/progression stages of DMBA induced rat mammalian carcinogenesis. Carcinogenesis 9: 331-332 (1988) 40. Lowenstein W.R.: Junctional intercellular communication and the control of growth. Biochem. Biophys. Acta 560: 1-65 (1979) 41. Zhang L.-.X, Cooney R.V., Bertram J.S.: Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1 /2 cells. Carcinogenesis 12: 2109-2114 (1991) 42. Hill D.L., Grubbs C.J.: Retinoids and cancer prevention. Annu. Rev. Nutr. 12: 161-181 (1992) 43. Oren M.: The involvement of oncogenes and tumor suppressor genes in the control of apoptosis. Cancer Metastasis Rev. 11: 141-148 (1992) 44. Bursch W., Oberhammer F., Schulte-Hermann R.: Cell death by apoptosis and is protective role against disease. Trends Pharmacol. Sci. 13: 245-251 (1992) 45. Labayle D., Fischer D., Vielh P., et al.: Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastrenterology 101: 635-639 (1991) 46. Wainfain E., Poirier A.: Methyl groups in carcinogenesis: effects of DNA methylation and gene expression. Cancer Res. 52: 2071-2077 (1992) 47. Wainfain E., Dizik M.: Suppression by methionine and choline of onco-fetal patterns of liver t-RNA methyltransferase activities in carcinogen treated rats. Carcinogenesis 8: 615-617 (1987) 48. Troll W.,. Kennedy A.R.: Protease inhibitors as cancer chemopreventive agents. Cancer Res. 49: 499-502 (1988) 49. Reddy B.S., Maruyama H., Kelloff G.: Dose related inhibition of colon carcinogenesis by dietary piroxicam, a non steroidal antiinflammatory drug, during different stages of rat colon tumor development. Cancer Res. 47: 5340-5346 (1987) 50. Huang M.-T., Lysz T., Ferraro T., et al.: Inhibitory effects of curcumin on in vitro lipooxygenase and cyclo-oxygenase activities in mouse epidermis. Cancer Res. 51: 813-819 (1991) |
Online ISSN 1011-6575
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση-Οδηγίες προς τους Συγγραφείς
What is Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition-Instrunctions to Authors
Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition
Συντακτικη Επιτροπή-Editorial Board
ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
|
||
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek
|
|
Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (70 €) –
Digital Type: pdf (70 €) pharmakonpress[at]pharmakonpress[.]gr
|
|
Έντυπη Μορφή (70 € + έξοδα αποστολής)
Printed Type (70 € + shipping) pharmakonpress[at]pharmakonpress[.]gr
|