Τόμος 17 (1999) – Τεύχος 2 – Άρθρο 3Σ – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 17 (1999) – Issue 2 – Article 3Σ – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Μηχανισμοί Χημειοπροφύλαξης στον Καρκίνο

Mechanisms of Chemoprevention in Cancer

Συγγραφέας – Author

Χαριτίνη Νέπκα1, Δημήτρης Κουρέτας2

1 Κυτταρολογικό Εργαστήριο, Σέρρες, Ελλάς 2 Τμήμα Γεωπονίας, Πανεπιστήμιο Θεσσαλίας, Βόλος, Ελλάς

Ch. Nepka, D. Kouretas

Laboratory of Animal Physiology, School of Agri­culture, Uni­versity of Thessaly, Pedion Areos, Volos, Greece

Παραπομπή – Citation

Νέπκα,Χ., Κουρέτας,Δ. : Μηχανισμοί Χημειοπροφύλαξης στον Καρκίνο , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 17 : 121-128 (1999)

Nepka,Ch., Kouretas,D. : Mechanisms of Chemoprevention in Cancer, Epitheorese Klin. Farmakol. Farmakokinet. 17: 121-128 (1999)

Ημερομηνία Δημοσιευσης – Publication Date
10-09-1999
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €)
Digital Type: pdf (15 )
pharmakonpress[at]pharmakonpress[.]gr
Λέξεις κλειδιά – Keywords

Καρκίνος, χημειοπροφύλαξη, μηχανισμοί

Cancer, chemoprevention, mechanisms
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Στο άρθρο αυτό ανασκοπούνται οι σύγχρονες απόψεις που αφορούν στους μηχανισμούς δράσης των χημειοπροφυλακτικών για τον καρκίνο ουσιών. Ο όρος χημειοπροφύλαξη χρησιμοποιείται για να περιγράψει την πρόληψη, αναστολή ή αντιστροφή της καρκινογενετικής διαδικασίας με τη χορήγηση ενός ή περισσότερων χημικών ουσιών με τη μορφή φαρμάκων ή με τα φυσικά συστατικά των τροφών. Οι χημειοπροφυλακτικές ουσίες, ανάλογα με τη χρονική περίοδο που εμφανίζουν τη δράση τους σε πειραματικά μοντέλα καρκινογένεσης στα πειραματόζωα μπορεί να ταξινομηθούν σε 3 κατηγορίες: στους αναστολείς του σχηματισμού καρκινογόνου, σε παράγοντες παρεμπόδισης της δράσης του καρκινογόνου κατά την πρώτη φάση της καρκινογένεσης και σε παράγοντες καταστολής της νεοπλασματικής ανάπτυξης με δράση κατά την προαγωγική ή εξελικτική φάση της καρκινογένεσης. Αρκετοί ωστόσο χημειοπροφυλακτικοί παράγοντες φαίνεται να δρουν μέσω περισσότερων από ένα μηχανισμών, γεγονός που δυσκολεύει την κατάταξή τους σύμφωνα με τον περισσότερο δραστικό μηχανισμό. Η συζήτηση επάνω στους βασικούς μηχανισμούς δράσης των χημειοπροφυλακτικών ουσιών συνοδεύεται από συγκεκριμένα παραδείγματα. Ο πλήρης κατάλογος των μέχρι σήμερα γνωστών χημειοπροφυλακτικών ουσιών εκφεύγει του σκοπού του άρθρου αυτού.

The mechanisms through which cancer chemoprevention agents inhibit carcino­genesis are reviewed. Cancer chemoprevention can be defined as prevention, inhibition or reversal of carcinogenesis by administration of one or more chemical compounds, either as sub­stances given as a medication formula or prophy­lactic therapy, or as naturally occurring constitu­ents of the diet. According to the time period that chemoprevention agents exert their activity in animal models, they can be classified into three classes: Inhibitors of carcinogen formation, block­ing agents with action in the initiation phase of carcinogenesis (inhibitors of expression of phase I enzymes, inducers of phase II enzymes, free radical scavengers, etc) and tumor suppressing agents with inhibitory action in the promo­tion/progression phase of carcinogenesis (inducers of cell death, regulators of steroid hormone action, regulators of signal transduction pathways, etc). Many chemopreventive agents act through more than one mechanism, making it difficult to classify them according to the most effective mode of action. Examples of various agents that act through these mechanisms are presented.

Αναφορές – References
1. Morse M.A., Stoner G.C.: Cancer chemoprevention: principles and prospects. Carcinogenesis 14: 1737-1746 (1993)

2. Kelloff G.J., Boone C.W., Steele V.E., et al. : Progress in cancer chemopreven­tion: perspectives on agent selection and short term clinical intervention trials. Cancer Res. 54: 2015-2024 (1994)

3. Greenwald ., Kelloff G., Burch Whitman C., Kramer B.S.: Chemoprevention CA. Cancer J. Clin. 45: 31-49 (1995)

4. ACS. Cancer Facts and Figures. GA: American Cancer Society, 1-3, Atlanta, 1995

5. Wattenberg L.W.: Chemoprevention of cancer. Cancer Res. 45: 1-8 (1985)

6. Mirvish S.S.: Ascorbic acid inhibition of N-nitroso compound formation in chemical, food and biological systems. In: Inhibition of Tumor Induction and Develop­ment (Zedeck M.S., Lipkin M., eds). Pp. 101-126, Plenum, New York, 1981

7. Hartman P.E., Shankel D.M.: Antimutagens and anti-carcinogens: a survey of putative interceptor molecules. Environ. Mol. Mutagen. 15: 145-182 (1990)

8. Kuenzig W., Chau J., Norkus E., et al.: Caffeic acid and ferulic acid as blockers of nitrosamine formation. Carcino­genesis 5: 309-314 (1984)

9. Shenoy N.R., Choughuley A.S.U.: Inhibitory effect of diet related sulfydryl compounds on the formation of carcino­genic nitrosamines. Cancer Lett. 65: 227-232 (1992)

10. Miller E.C., Miller J.A.: Some historical perspectives on the metabolism of xenobiotic chemicals to reactive electrophils. In: Bioactivation of Foreign Compounds (Anders M.W., ed.). Pp. 1-28, Academic Press, New York, 1985

11. Conney A.H.: Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: GHA Clowes Memorial Lecture. Cancer Res. 42: 4875-4917 (1982)

12. Morse M.A., Eklind K.I., Hecht S.S., et al.: Structure activity relationships for inhibition of 4-methylnitrosamino-1-3(pyridyl)-1-dutanone (NNK) lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 51: 1846-1850 (1991)

13. Stoner G.D., Siglin J.C., Morse M.A., et al., Francis D.J.: Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenyl hexyl isothiocyanate. Carcinogenesis 16: 2473-2476 (1995)

14. Wattenberg L.W., Loub W.D.: Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res. 38: 1410-1413 (1978)

15. Tanaka T., Mori Y., Morishita Y., et al.: Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine induced hepatocarcino­genesis in male ACI/N rats. Carcino­genesis 10: 175-181 (1990)

16. Pence B.C., Buddingh F., Yang S.P.: Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. J. Natl. Cancer Inst. 77: 269-276 (1986)

17. Bailey G.S., Hendricks J.D., Shelton D.W., et al.: Enhancement of carcinogenesis by the natural anticarcino­gen indole-3-carbinol. J. Natl. Cancer Inst. 78: 931-934 (1987)

18. Zhang Y., Talalay P., Cho C.-G., Posner G.H.: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89: 2399-2403 (1992)

19. Zhang Y., Kensler T.W., Cho C.-G., et al.: Anticar­cinogenic activities of sulforaphane and structurally related synthetic norbonyl isothiocyanates. Proc. Natl. Acad. Sci. USA 91: 3147-3150 (1994)

20. Roebuck B.D., Liu Y.-L., Rogers A.E., et al.: Protection against aflatoxin B1 induced hepatocarcino­genesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz): predictive role of molecular dosimetry. Cancer Res. 51: 5501-5506 (1991)

21. Sayer J.M., Yagi H., Wood A.W., et al.: Extremely facile reaction between the ultimate carcinogen ben­zo[a]pyrene-7,8-diol-9,10epoxide and ellagic acid. J. Am. Chem. Soc. 104: 5562-5564 (1982)

22. Packer J.E., Mahood J.S., Mora-Arellano V.O., et al.: Free radicals and singlet oxygen scavengers: reaction of a peroxy radical with beta-carotene, diphenyl furan and 1,4-di­azobicyclo (2,2,2)-octane. Biochem. Biophys. Res. Commun. 98: 901-906 (1981)

23. Kensler T.W., Trush M.A., Guyton K.Z.: Free radicals as targets for cancer chemoprevention: prospects and problems. In: Cellular and Molecular Targets for Chemo­prevention (Steele V.H., Stoner G.D., Boone C.W., Kelloff G.J., eds). Pp. 173-191, CRC Press, Boca Raton, FL, 1992

24. Imanishi H., Sakaki Y.F., Matsumoto K., et al.: Sup­pression of 6-TG- resistant mutations in V79 cells and recessive spot formations in mice by vanillin. Mutat. Res. 243: 151-158 (1990)

25. Farzaneh F., Panayotou G.N., Bowler L.D., et al.: ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome. Nucleic Acid Res. 16: 1319-1326 (1988)

26. Cesarone C.F., Scovassi A.I., Scarabelli L., et al.: Depletion of adenosine diphosphate-ribosyl transferase activity in rat liver during exposure to N-2-acetylaminofluo­rene: effect of thiols. Cancer Res. 48: 3581-3585 (1988)

27. Meyn S.M., Rossman T., Troll W.A.: A protease inhibitor blocks SOS functions in Escherichia Coli: Antipain prevents lambda repressor inactivation, ultraviolet mutagenesis and filamentous growth. Proc. Natl. Acad. Sci. USA 74: 1152-1156 (1977)

28. De Flora S., Ramel C.: Classification of mechanisms of inhibitors of mutagenesis and carcinogenesis. Basic Life Sci. 52: 461-462 (1990)

29. Kelloff G.J., Boone C.W., Steele V.E., et al.: Mecha­nistic considera­tions in chemopreventive drug develop­ment. J. Cell. Biochem. (Suppl.) 20: 1024 (1994)

30. Pegg A.E.: Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 48: 759-774 (1988)

31. Slaga T.J.: Overview of tumor promotion in animals. Environ. Health. Perspect. 50: 3-14 (1983)

32. Thompson H.J., Ronan A.M.: Inhibition of 1-methyl-1-nitrosourea induced mammary tumorigenesis by a-difluoromethylornithine and retinyl acetate. Proc. Am. Assoc. Cancer Res. 24: 86 (1983)

33. Whitfield J.F.: Calcium: driver of cell cycles, trigger of differentiation, and killer of cells. In: Cellular and Molecular Targets for Chemoprevention (Steele V.E., Stoner G.D., Boone C.W., Kelloff G.J., eds). Pp. 257-311: CRC Press, Boca Raton FL, 1992

34. Huang F.L., Roop D.R., De Luca L.M.: Vitamin A deficiency and keratin biosynthesis in cultured hamster trachea. In Vitro Cell Dev. Biol. 22: 223 (1986)

35. Sani B.P., Singh R.K., Reddy L.G., Gaub M.-P.: Isolation, partial purification and characterization of nuclear retinoid acid receptors from chick skin. Arch. Biochem. Biophys. 283: 107-113 (1990)

36. Kelloff G.J., Boone C.W., Steele V.E., et al.: Inhibition of chemical carcinogenesis. In: Chemical Induction of Cancer: Modulation and Combination Effects (Arcos J., Argus M., Woo Y., eds). Birkhauser Boston, 1997

37. Roberts A.B., Sporn M.B.: Transforming growth factor β. Adv. Cancer Res. 51: 107-145 (1988)

38. Jordan V.C.: The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 70: 977-982 (1992)

39. Elson C.E., Maltzman T.H., Boston J.L., et al.: Anti-carcinogenic activity of D-limonene during the initiation and promotion/progression stages of DMBA induced rat mammalian carcinogenesis. Carcinogenesis 9: 331-332 (1988)

40. Lowenstein W.R.: Junctional intercellular communica­tion and the control of growth. Biochem. Biophys. Acta 560: 1-65 (1979)

41. Zhang L.-.X, Cooney R.V., Bertram J.S.: Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1 /2 cells. Carcinogenesis 12: 2109-2114 (1991)

42. Hill D.L., Grubbs C.J.: Retinoids and cancer preven­tion. Annu. Rev. Nutr. 12: 161-181 (1992)

43. Oren M.: The involvement of oncogenes and tumor suppressor genes in the control of apoptosis. Cancer Metastasis Rev. 11: 141-148 (1992)

44. Bursch W., Oberhammer F., Schulte-Hermann R.: Cell death by apoptosis and is protective role against disease. Trends Pharmacol. Sci. 13: 245-251 (1992)

45. Labayle D., Fischer D., Vielh P., et al.: Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastrenterology 101: 635-639 (1991)

46. Wainfain E., Poirier A.: Methyl groups in carcinogene­sis: effects of DNA methylation and gene expression. Cancer Res. 52: 2071-2077 (1992)

47. Wainfain E., Dizik M.: Suppression by methionine and choline of onco-fetal patterns of liver t-RNA methyltrans­ferase activities in carcinogen treated rats. Carcinogenesis 8: 615-617 (1987)

48. Troll W.,. Kennedy A.R.: Protease inhibitors as cancer chemopreventive agents. Cancer Res. 49: 499-502 (1988)

49. Reddy B.S., Maruyama H., Kelloff G.: Dose related inhibition of colon carcinogenesis by dietary piroxicam, a non steroidal antiinflammatory drug, during different stages of rat colon tumor development. Cancer Res. 47: 5340-5346 (1987)

50. Huang M.-T., Lysz T., Ferraro T., et al.: Inhibitory effects of curcumin on in vitro lipooxygenase and cyclo-oxygenase activities in mouse epidermis. Cancer Res. 51: 813-819 (1991)

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
Chemical Abstracts

Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
Γλώσσα Πλήρους Κειμένου –
Full Text Language
Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (70 €) –
Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr
Έντυπη Μορφή (70 € + έξοδα αποστολής)
Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr

 

Προσθέστε στους σελιδοδείκτες το μόνιμο σύνδεσμο.

Τα σχόλια είναι απενεργοποιημένα.