Τόμος 12 (1994) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 12 (1994) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

 

Τίτλος – Title

Σύγχρονη Θέση των Κορτικοστερινοειδών στη Θεραπεία των Λοιμώξεων: Μέρος ΙΙ

Corticosteroid Therapy and Infection

Συγγραφέας – Author

Γεώργιος Ν. Καραχάλιος

Γ’ Παθολογικό Τμήμα του Νοσοκομείου του Ελληνικού Ερυθρού Σταυρού, Αθήνα

George Karachalios

Red Cross Hospital

Παραπομπή – Citation

Καραχάλιος,Γ.Ν. : Σύγχρονη Θέση των Κορτικοστερινοειδών στη Θεραπεία των Λοιμώξεων: Μέρος ΙΙ , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 12 : 17-40 (1994)

Karachalios,G. : Corticosteroid Therapy and Infection, Epitheorese Klin. Farmakol. Farmakokinet. 12 : 17-40 (1994)

Ημερομηνία Δημοσιευσης – Publication Date
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords

Κορτικοστερινοειδή, λοιμώξεις, άμυνα ξενιστή, συχνότητα λοιμώξεων, θεραπεία λοιμώξεων

Corticosteroids, infections, host defence, incidence of infections, therapy
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

The relationship between corticoster­oid therapy and infection is something of a medi­cal paradox. Used in the context of inflammatory and malignant diseases, corticosteroids may enhance activation of a latent infection or com­promise host defence against newly encountered pathogens. Yet, these drugs are employed for their anti-inflammatory properties in a variety of infections. Corticosteroids have numerous effects on inflammatory and immune processes. In gen­eral, corticosteroids have greater effects on leukocyte traffic than on function, and they have more effects on cellular than hummoral proc­esses. The most important physiological and clinical effect of corticosteroids administration in human is their ability to inhibit the concentration of neutrophils and monocyte-macrophages at the inflammation site. Corticosteroids produce marked lymphocytopenia secondary to a redistribution of lymphocytes out of the circulation to other lym­phoid compartments, affecting T-lymphocytes more than other population. Corticosteroids inhibit the eicosanoids, cytocines and various other factors. The beneficial effects of corticosteroids reported n many patients with infectious diseases. In the present article we reviewed the literature on the effects of corticosteroids on host defence, the incidence of infections in patients treated with prolonged corticosteroid therapy and finally the use of corticosteroids in the treatment of infec­tious diseases.

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