Open Access Research
Aqueous coriander (Coriandrum sativum L.) seed extract improves serum lipid profile in a coconut oil–induced hyperlipidemic mouse model
Malak Emrane Dakeal1,2*
, Aisha Elhatimi3, Mohanad Faris Raheem4, Yaman Walid Kassab4,5, Abdulfatah Gbaj6, Abdelrazzag El-Majdoub6, Ashraf Ward6
1Department of Medical Technology, Alawata College of Applied Sciences and Technology, Libya
2Libyan Academy for Postgraduate Studies, Tripoli, Libya
3Higher Institute of Science and Technology Souk El Khemis, Imsehel, Libya
4Collage of Pharmacy, National University of Science and Technology, Muscat, Oman
5College of pharmacy, Al-Bayan University, Baghdad, Iraq
6University of Tripoli, Libya
*Corresponding author:
Malak Emrane Dakeal, Department of Medical Technology, Alawata College of Applied Sciences and Technology, Libya; Tel.: +218-914756719; E-mail: malakdakeal@gmail.com
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Published: 2026 ; https://doi.org/10.61873/
Abstract
Background: Hyperlipidemia is a major risk factor for cardiovascular disease and has increased interest in plant‑based interventions to improve lipid metabolism. Coriandrum sativum contains bioactive compounds that may influence serum lipid levels. Aim: This study investigates the hypolipidemic effects of aqueous coriander seed extract in a mouse model of coconut oil–induced hyperlipidemia, focusing on serum lipid profiles (TC, TG, HDL, LDL). Methodology: An aqueous extract of Coriandrum sativum seeds was prepared at 100 g/L. Male albino mice (25–30 g) received daily oral doses of 0.5 mL or 1 mL (≈ 2–4 mg/kg) by oral gavage for ten days. Serum lipid parameters including total cholesterol (TC), triglycerides (TG), high‑density lipoprotein (HDL), and low‑density lipoprotein (LDL) were measured using an Integra 400 Plus autoanalyzer with commercial assay kits (BioSystems, Barcelona, Spain). Results: The Control group showed a mean TC of 134.3 ± 7.9 mg/dL. The Coconut Oil group exhibited significantly elevated TC, TG, and LDL compared with controls (p<0.001). The Safety group (extract only) and the Protected groups (extract before coconut oil) demonstrated lower TC and LDL values compared with the Coconut Oil group (p<0.001). HDL values were higher in the Protected groups compared with controls (p<0.05). The Treated groups (extract after coconut oil) showed reductions in TC and TG compared with the Coconut Oil group (p<0.001), with moderate increases in HDL (p<0.05). No significant differences were observed between 0.5 mL and 1 mL doses (p>0.05). Conclusion:Coriander seed extract may have hypolipidemic effects in mice, suggesting a potential complementary role in the management of hyperlipidemia. Further studies, including mechanistic investigations and human clinical trials, are needed to clarify its therapeutic utility.
Keywords: coriander, hyperlipidemia, cholesterol, triglycerides, lipid metabolism
Please cite as:
Dakeal M. E., Elhatimi A., Raheem M. F., Kassab Y. W., Gbaj A., El-Majdoub A., Ward A.: Aqueous coriander (Coriandrum sativum L.) seed extract improves serum lipid profile in a coconut oil–induced hyperlipidemic mouse model. Epitheorese Klin. Farmakol. Farmakokinet. xx(xx): xx-xx (2026). DOI: 10.61873/XXXXXXX
pISSN 1011-6575 • eISSN 2945-1914