Open Access Research
Therapeutic potential of Coriandrum sativum seed extract in hyperlipidemia induced hepatic damage: a histomorphological study in mice
Malak Emrane Dakeal1,2*, Aisha Elhatimi3, Yaman Walid Kassab4,5
, Hayder A. H. Jalil5, Abdulfatah Gbaj6, Ashraf Ward6, Abdelrazzag El-Majdoub6
1Department of Medical Technology, Alawata College of Applied Sciences and Technology, Libya
2Libyan Academy for Postgraduate Studies, Tripoli, Libya
3Department of Medical Laboratory Technology, Higher Institute of Science and Technology Souk El Khemis, Imsehel, Libya
4College of Pharmacy, National University of Science and Technology, Muscat, Oman
5College of Pharmacy, Al-Bayan University, Baghdad, Iraq
6University of Tripoli, Libya
*Corresponding author:
Malak Emrane Dakeal, Department of Medical Technology, Alawata College of Applied Sciences and Technology, Libya; Tel.: +218-914756719; e-mail: malakdakeal@gmail.com
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Published: 2026 ; https://doi.org/10.61873/
Abstract
Background: Hyperlipidemia is associated with hepatic injury through lipid accumulation, inflammation, and cellular degeneration. Plant-derived agents are increasingly studied for their hepatoprotective potential due to their bioactive constituents. Aim: This study evaluated the hepatoprotective and therapeutic effects of aqueous Coriandrum sativum seed extract on hyperlipidemia-induced liver damage in mice. Methodology: Male albino mice were divided into control, hyperlipidemia, safety, protection, and treatment groups. Hyperlipidemia was induced by coconut oil, and the extract was administered orally at 0.5 mL (≈200 mg/kg) or 1.0 mL (≈400 mg/kg). Liver tissues were processed and stained with hematoxylin and eosin (H&E) for blinded histopathological evaluation. Results: Hyperlipidemia caused hepatocellular atrophy, portal inflammation, vascular congestion, and necrosis. Administration of C. sativum extract was associated with observable preservation of hepatic architecture and reduction in inflammatory changes. In prophylactic groups, histological features appeared closer to normal liver tissue. Conclusion: This study provides descriptive histopathological evidence that aqueous Coriandrum sativum seed extract was associated with histological features suggestive of attenuated liver injury induced by hyperlipidemia in a mouse mode model. The extract was associated with preservation of hepatic architecture, reduction of inflammatory changes, and attenuation of hepatocellular damage. These findings support C. sativum as a potential natural intervention to address hyperlipidemia associated histomorphological liver pathology. Further research utilizing standardized scoring systems and detailed mechanistic analyses is warranted to further characterize its potential biological relevance.
Keywords: Coriandrum sativum, hyperlipidemia, liver, histopathology, hepatoprotection
Please cite as: Dakeal M. E., Elhatimi A., Kassab Y. W., Jalil H. A. H., Gbaj A., Ward A., El-Majdoub A.: Therapeutic potential of Coriandrum sativum seed extract in hyperlipidemia induced hepatic damage: a histomorphological study in mice. Epitheorese Klin. Farmakol. Farmakokinet. xx(xx): xx-xx (2026). DOI: 10.61873/XXXXXXX
pISSN 1011-6575 • eISSN 2945-1914