Volume 42 (2024) – Supplementary Issue 1 – Article 8 – Epitheorese Klinikes Farmakologias kai Farmakokinetikes

Open Access Research

Nigella oriental seeds as a model for examining the impact of silver nanoparticles and cabergoline on female rats with hyperprolactinemia: a comparative study

Sulaiman M. Hasan^1,*
¹Department of Basic Science, College of Dentistry, Mustansiriyah University, Baghdad, Iraq

*Corresponding author
Sulaiman M. Hasan, Department of Basic Science, College of Dentistry, Mustansiriyah University, Baghdad, Iraq; e-mail: sulaiman.m.hasan@uomustansiriyah.edu.iq

Published: 27 December 2024; https://doi.org/10.61873/HKCQ9871

Abstract
Plant extracts from Nigella sativa seeds were employed to synthesize silver nanoparticles (AgNPs) from silver nitrate solution. The AgNPs were characterized by spectroscopy, UV spectrophotometry, scanning electron microscopy (SEM), and F-TIR. Thirty female Albino Wistar rats were divided mainly into (3) groups (Group 1, Group 2: Group 2a and Group 2b) where (10) rats have been distributed for each. The animal experiment was undergone through three stages; in the first stage, group 2 was given chlorpromazine orally (30 mg/BW) by gavage needle for a period of 28 days. After three days from the treatment, serum prolactin levels were estimated. During the subsequent phase, G2a received intraperitoneal (IP) injections of AgNPs (25 mg/BW) whereas G2b received IP injections of cabergoline (30 mg/BW). In the third stage, all animals were put out two months after the experiment began, and an Elisa Kit was used to measure the prolactin levels in the serum. This study investigated the effects of cabergoline and AgNPs on prolactin levels in female rats and utilized AgNPs to treat hyperprolactinemia. The study’s extracted AgNPs has shown a strong inhibitory effect on hyperprolactinemia, which may bolster the role of AgNPs in the field of nanomedicine.