Open Access Research
Utilization of co-crystallization technology to enhance the solubility and the dissolution profiles of famotidine
Lina S. Hussein1,*
1Department of Pharmacognosy, College of Pharmacy, University of Thi-Qar, Nasiriyah, Iraq
*Corresponding author
Lina S. Hussein, Department of Pharmacognosy, College of Pharmacy, University of Thi-Qar, Nasiriyah, Iraq; Tel.: +964-7811567094; e-mail: linasalim@utq.edu.iq
Published: 27 December 2024; https://doi.org/10.61873/XAIW5293
Abstract
Background: Co-crystallisation is a useful technique that can be used to improve important physicochemical properties of drugs that have solubility troubles, without any chemical modification. Aim: This study investigates the co-crystallization of the poorly soluble drug famotidine (FMT) with either nicotinamide (NIC) or urea as co-formers. Methodology: The method employed for preparation was solvent evaporation at a predetermined stoichiometric ratio. The prepared formulations were evaluated for their solubility, while a selected co-crystal (FMT1) was also assessed through the undertaking of in vitro dissolution, differential scanning calorimetry, and Fourier transform infrared spectrometry. Results: All the prepared formulations demonstrated an improvement in drug solubility compared to the pure drug. However, FMT1, which contains a 1:1 ratio of FMT to NIC, yielded the best results. Conclusion: The findings of this study can suggest that the solubility and dissolution profile of FMT might be successfully enhanced by this technique.
Keywords: co-crystals, famotidine, nicotinamide, urea, solvent evaporation technique
Please cite as:
Hussein L. S.: Utilization of co-crystallization technology to enhance the solubility and the dissolution profiles of famotidine. Epitheorese Klin. Farmakol. Farmakokinet. 42(Sup1): 53-59 (2024). DOI: 10.61873/XAIW5293
pISSN 1011-6575 • eISSN 2945-1914