Τόμος 22 (2008) – Τεύχος 2 – Review of Clinical Pharmacology and Pharmacokinetics-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Review of Clinical Pharmacology and Pharmacokinetics-International Edition

5th Panhellenic Congress of Pharmacology
0 Letter from Guest Editor
Charis Liapi
1 Changes in pharmacological and functional properties of human 5-HT receptors by genetic, splice and subunit variation
Manfred Gothert
2 The role of nuclear receptor in regulation of CYPs
Paavo Honkakoski
3 Neuroprotection: the difficult journey from the bench to the bedside
Cristina Sampaio
4 Biological factors: new perspectives in the treatment of auto immune diseases
P. Athanasiou
5 Multi-drug targeting as a new basis in pharmacology
Ch. Flordellis and P. Papathanassopoulos
6 New treatment approaches in multiple myeloma therapy
E. Kastritis
7 Pathophysiology of osteoplastic metastasis in prostate cancer: therapeutic implications
M. Koutsileris
8 Sex differences in drug response
Z. Papadopoulou-Daifoti
9 Neurobiological mechanisms underlying drug addiction: is there a common pathway?
Dora Duka
10 Regenerative pharmacology
A. Gravanis
11 Introduction to herbals
I. Chinou
12 Herbal and dietary supplement – drug interactions: evidence for clinical signifcance
P. Galanopoulou-Couvari
13 Herbal medicinal products in Europe
Werner Knoss
14 The legal situation regarding the use of vitamins, minerals and certain other ingredients in foods
Basil Mathioudakis
15 Medical foods and dietary supplements: minimal requirements for safe clinical use
T.C. Theoharides
16 Docendo discimus: teaching pharmacology in the modern Europe
Filippo Drago
17 Medical curricula between sharpening universities’ indivdual profiles and the need for speed: effects on pharmacology teaching in Austria
Thomas Griesbacher
18 How can we best prepare medical students to be safe and effective prescribers?
Simon Maxwell
19 Education in pharmacology: knowledge or attitude?
J.S. Papadopulos
20 Pharmacology: from basic principles to translational medicine to clinical practice
T.C. Theoharides
21 Antiatheromatic and hypolipidemic activity of Chios mastic gum in anesthetized rabbits
I. Andreadou, S. Paraschos, E. K. Iliodromitis, A. Zoga, P. Magiatis, S. Mitakou, L. Kaklamanis, A.L. Skaltsounis and D.Th. Kremastinos
22 CB1R-dependent activation of fyn tyrosine kinase and protein kinase C Delta, PKCδ, in lipid rafts
O. Asimaki, N. Sakellaridis and D. Mangoura
23 In vivo evaluation of CUP1A2 and CYP2A6 activities in a Greek population during menopause
E. Begas, E. Kouvaras, V. Tsiokou and E.K. Asprodini
24 Lazaroids: a new category of neuroprotective agents
A. Bibis, G. Dimogerontas, K. Kouzelis, A. Zarros and C. Liapi
25 Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of anxiety
A. Boultadakis, G. Georgiadou, P.A. Tarantilis and N. Pitsikas
26 Synthetic spiro-neurosteroid analogs exerting structure-specific neuroprotective effects
I. Charalampopoulos, V. Minas, N. Avlonitis, T. Calogeropoulou and A. Gravanis
27 Corticotropin Releasing Factor (CRF) and liver apoptosis
E. Chatzaki, C. Paschos, M. Lambropoulou, S. Anagnostoulis, Ch. Charsou, E. Chouridou, E. Michailidou, F. Papachristou, Th.C. Constantinidis and C. Simopoulos
28 Behavioral effects and dopaminergic indices following the administration in two rat phenotypes
O. Chouliara, A. Polissidis, M. Dosi, A. Galanopoulos, E.Tzavara, M. Marselos, Z. Papadopoulou-Daifoti, C. Spyraki and K. Antoniou
29 Occupational exposure of health care workers to chemotherapeutic agents: a study in Greek hospitals
Th.C. Constantinidis, E. Vagka, P. Dallidou, P. Basta, V. Drakopoulos and E. Chatzaki
30 Hepatic drug metabolizing efficacy modifications after exposure to stress
E.P. Daskalopoulos, G. Rentesi, M.A. Lang, M. Marselos and M. Konstandi
31 Sex differences in pharmacokinetics of doxorubicin
E. Dimitriadi, M. Nikolaidou, P. Pappas and M. Marselos
32 Chemotherapy of osteosarcoma: beyond conventional approaches to future concepts
Ch. Dokos, Κ. Kalousis, A. Kouyoumtzis and M. Mironidou-Tzouveleki
33 Hyaluronic acid induces wound closure by primary human skin fibroblasts in a wound healing model
D. Economou, E. Papakonstantinou, I. Klagas, Ath. Sakadamis and A. Sioga
34 Caspase-3 activity in pregnant rat spleen and lymph nodes after treatment with cycloheximide and the development of malignant breast tumor in experimental animals: case report
H. Frangou, E. Nikoloussis, N. Massouridou, T. Vavilis and E.-N. Emmanouil
35 Glutamatergic alterations following cannabinoid administration
A. Galanopoulos, A. Polissidis, O. Chouliara, Z. Papadopoulou-Daifoti and K. Antoniou
36 Simple physicochemical properties as effective filters for risk estimation of drug transport across the human placental barrier
C. Giaginis, A. Zira, S. Theocharis and A. Tsantili-Kakoulidou
37 Antagonistic effect of TGF-β1 on the IL-1β-induced expression of MMP-1 in human fibroblasts of different tissue origin
M. Giannakouli, A.J. Aletras and E. Giannopoulou
38 The C-termini of the μ– and δ– opioid receptors differentially bind to Signal Transducers and Activators of Transcription, STAT5A and STAT5B
E.-M. Georganta, G. Mazarakou, A. Agalou and Z. Georgoussi
39 Physicians and the use of antibiotics in Cyprus
Ch. Hadjimichael, S. Savva, A. Andreou and S. Theocharous
40 Eph receptors and ephrin ligands: back to the origin in the therapy of cancer
C. Hadjicosta and M. Mironidou-Tzouveleki
41 Assessment of motoneuron death during development following central and peripheral deafferentation
A. Hatzisotiriou, D. Kapoukranidou and M. Albani
42 Genotoxic and cytostatic effect of atypical antipsychotic drugs in normal human lymphocytes cultures
Z. Iakovidou-Kritsi, K. Akritopoulou, M.T. Ekonomopoulou, T. Lialiaris, D. Mourelatos and E. Mioglou-Kalouptsi
43 Study of the effect of statin antilipidemic therapy on the thyroid
I. Ilias, M. Alexiou, K. Michalakis, G. Mitios, E. Venaki and S. Nikopoulou
44 The role of polymorphisms in 5-HT2c receptor gene in type 2 diabetes mellitus and obesity in the Caucasian population
M. Iordanidou, A. Tavridou, M.V. Vasseiliadis, K.I. Arvanitidis, J. Petridis, D. Christakidis and V.G Manolopoulos
45 The effect of rupatadine on histamine-induced oedema formation and TNF-α gene expression in the rat paw
K. Kalokasidis, D. Molyva, V. Mirtsou, H. Dedi, B. Kokkas and A. Goulas
46 Cholinesterase inhibitors and memantine in vascular dementia: a systematic review of randomized controlled trials 
C. Kani, K. Papanikolaou, A. Pehlivanidis and Z. Papadopoulou-Daifoti
47 Effects from chronic iron administration on functional organs: correlation with free radicals
D. Kapoucranidou, R. Kotakidou, M. Pontika and D. Hadjipavlou-Litina
48 Salmonella enterica serovar typhi Ty21a expressing HPV Type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever
Ch. Karachalios
49 False positive tumour markers CA 15-3, CEA, CA 125 and CA 19-9 in patients with homozygous β-thalassaemia, sickle cell / β-thalassaemia and thalassaemia intermedia
I. Karamouzis, F. Kesidon, E. Hasapopoulou, C. Manolopoulos, B. Papageorgiou, M. Giannoulis, E. Sampanopoulou, D. Michailidou, Th. Dardavessis, M. Karamouzis and I. Pidonia
50 Sustained activation of CREB is required for neuronal differentiation of α2-AR transfected PC12 cells
G. Karkoulias, K. Kypreos, P. Papathanasopoulos, Ch. Flordellis
51 Expression of cytochrome P450s and transcription factors pxr and car in canine tissues
D.S. Katsiabas, S.K. Mavridis and I.S. Pappas
52 A pharmacoeconomic comparison study of an lc/ms method used for the bioequivalence study of donepezil compared with a similar HPLC method for the same substance
K. Katsikaris, I. Skopelitis, A. Papaionannou, A. Gotsi and N. Karagiannidis
53 Effects of long-term antipsychotic treatment of oxidative defense system parameters
K. Kosma, A. Sianni, K. Liatsos, C. Leotsakou, A. Kalogeropoulou and V. Roumpos
54 Cholesteryl Ester Transfer Protein (CETP) changes under the influence of saturated fat diet and anabolic treatment in rats
A. Kotsiou, E. Chatzigianni, A. Pitsicali and C. Tesseromatis
55 The stimulatory effects of aprotinin on human endothelial and prostate cancer cells are mediated by pleiotrophin
M. Koutsioumpa, M. Hatziapostolou, C. Mikelis and E. Papadimitriou
56 Lower esophageal sphincter relaxing agents: an in vitro comparative study in the rabbit
M. Koutsoviti-Papadopoulou, Th.A. Psarra and  G.C. Batzias
57 In vitro responses of the guinea pig gastrointestinal tract to homologous motilin
M. Koutsoviti-Papadopoulou, L. Xu, I. Depoortere, L. Thielemans, Th. Thijs and Th.L. Peeters
58 Acute in vivo exposure to fentanyl reduces GABA immunoreactivity in the CA1 area of the rat hippocampus
E. Kouvaras, T. Kilindris, A. Vasilaki andE.K. Asprodini
59 RGS4 and RGS2 differentially modulate opioid receptor signaling
L.J. Leontiadis, M.-P. Papakonstantinou, M. Sarris and Z. Georgoussi
60 Anti-CTLA-4 therapy in bladder cancer patients alters immune responses by increasing IFNγ production and decreasing the CD4+FOXP3+ regulatory T cells in the tumor microenvironment
Ch.I. Liakou, A. Kamat, D. Ng Tang, H. Chen, J. Sun, Ch. Logothetis and P. Sharma
61 Lanthanum effects on the adult rat brain antioxidant status and adenosinetriphosphatase activities: modulation by L-cysteine
Ch. Liapi, A. Zarros, S. Theocharis, H. Al-Humadi, F. Anifantaki, E. Gkrouzman, Z. Mellios, N. Skandali and S. Tsakiris
62 Adrenal beta-arrestin 1 promotes physiological aldosterone production
A. Lymperopoulos and W.J. Koch
63 Pharmaceutical approach in mild cognitive impairment: is it advisable? recent data and prospects
Ch. Maglaras, M. Parava, P. Papadopoulos, D. Tsiptsios and P. Beredimas
64 Brain wave patterns and steroids administration
I. Maimari, Ch. Dokos and M. Mironidou–Tzouveleki
65 Τhe antagonizing effects of N-acetyl-cysteine on prolactin induced proliferation of human breast cancer cells
F.M. Malamas, C.G. Thomas, T. Stefos, A Tsatsoulis and A.M. Evangelou
66 Developmental heterogeneity in splicing of the postnatal rat retinal N-methyl-D-aspartate glutamate receptor 1
G. Manta, S. Taraviras, E. Kouvelas and A. Mitsacos
67 Hypolipidaemic and antioxidant properties of novel squalene synthase inhibitors
A.  Matralis and Α. Κourounakis
68 Expression of drug-metabolizing proteins in human brain tumors: preliminary results
M.C. Mavrogiorgou, P. Stavrinou, P. Pappas, G. Miliaras, K. Polyzoidis and M. Marselos
69 Evaluation of the effects of different mood stabilizers in a rat model of euphoria
M. Mavrikaki, G.G. Nomikos and G. Panagis
70 Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes
Th. Mavrakanas, E. Tsirella and M. Mironidou-Tzouveleki
71 Administration of antiplatelet agents in cardiovascular disorders: results from a clinical study
Μ. Mironidou-Tzouveleki, Ch. Dokos, M. Andronoglou, P. Papadimouli and K. Kalousis
72 Serum butyrycholinesterase activity as a marker of aging process in drug metabolism: study in Greek aging population
M. Mironidou-Tzouveleki, Ch. Dokos and Κ. Kalousis
73 Statins and bone formation: proposed methods of implementing statins innovation in osteoporosis
M. Mironidou-Tzouveleki and Ch. Dokos
74 The effect of Orlistat on blood glucose and body weight in an onset diabetic rat model
M. Mironidou-Tzouveleki, A. Anogeianaki, Ch. Dokos, D. Koutsonikolas, J. Liagouris and G. Anogianakis
75 The first identified mutation associated to Alternating Hemiplegia of Childhood (AHC) in a Greek family: clinical and genetical approach
K. Nazos, M.-T. Bassi, N. Bresolin and K. Pantos
76 Effects of a selective cyclooxygenase inhibitor on behavioural and neurochemical parameters
M. Nikolaidou, P. Pappas, K. Antoniou and M. Marselos
77 Preliminary evaluation of preoperative and short-term (1 year) postoperative serum fat-soluble vitamin levels in super-obese patients undergoing a Roux-en-Y Gastric Bypass with Biliopancreatic Diversion (RYGBP/BPD) malabsortive operation
Z. Panagi, P. Bountouris, E. Papadimitriou, M. Skouroliakou and F. Kalfarentzos
78 Preparation, characterization and in vitro evaluation of liposome-incorporated curcumin on colorectal cancer cell lines
M. Pantelidou, K. Dimas, A. Georgopoulos, S. Hatziantoniou and C. Demetzos
79 Hepatic regeneration after 60-70% and 30-34% partial hepatectomy in the rat
G.K. Papadimas, K.N. Tzirogiannis, M.D. Demonakou, S.D. Skaltsas, A.D. Grypioti, K.T. Kourentzi, K.N. Alexandropoulou, K. Sourlis, M.G. Mykoniatis and G.I. Panoutsopoulos
80 New kids on the block: statins in the fight against Alzheimer’s disease
P.K. Panagopoulos, S. Tsartsalis, Ch. Dokos and M. Mironidou-Tzouveleki
81 Quality of perioperative chemoprophylaxis in general surgery: preliminary results of ASPPOC in South Europe
P. Papaioannidou, A. Kambaroudis, V. Vlahovic-Palcevski, A. Sabo, L. Pejakov, B. Beovic,  R. Velickovic-Radovanovic, E. Karamanlis, A. Raskovic, C. Papanikolaou, M. Jakovljevic, H. Carageorgiou, I. Diamantis, G.M. Benoni, L. Cuzzolin, J. Petrovic, S. Jankovic, G. Hatzitheoharis, G. Velo, N. Harlaftis and Th. Gerasimidis
82 Quality of perioperative chemoprophylaxis in neurosurgery: preliminary results of ASPPOC in South Europe
P. Papaioannidou, K. Nanassis, A. Sabo, V. Vlahovic-Palcevski, L. Pejakov, O. Horvat3, M. Jakovljevic, P. Selviaridis, G.-M. Benoni, L. Cuzzolin, Z. Tomic, S. Jankovic and G. Velo
83 Quality of perioperative chemoprophylaxis in orthopedics surgery: preliminary results of ASPPOC in Greece and Italy
P. Papaioannidou, P. Akritopoulos, G.-M. Benoni, L. Cuzzolin and G. Velo
84 Quality of perioperative chemoprophylaxis in obstetrics and gynecology: preliminary results of ASPPOC in Greece and Italy
P. Papaioannidou, D. Vavilis, G.-M. Benoni, L. Cuzzolin, G. Velo, B. Tarlatzis and J. Bontis
85 Theoretical and practical issues of cognitive development in problem based learning
P. Papaioannidou
86 Succinylcholine in Rapid Sequence Induction (RSI): how safe is its use when there is evidence of intracranial changes?
M. Parava, Ch. Maglaras, D. Tsiptsios, M. Doulgerakis and P. Beredimas
87 Effects of pesticides on exposed populations from four European countries
S.M. Piperakis, K. Kontogianni, G. Karanastasi, C. Siffel, A. Cebulska-Wasilewska, R. Markos, Z. Iakovidou-Kritsi and M.M. Piperakis
88 The selective 5-HT6 receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
N. Pitsikas, S. Zisopoulou, I. Pappas and N. Sakellaridis
89 Neurochemical alterations following acute immune stimulation: a male versus female study 
P.M. Pitychoutis, K. Nakamura, P.A. Tsonis and Z. Papadopoulou-Daifoti
90 Gliadel wafers in the treatment of malignant glioma: our experience
S. Plakas, I. Spanos, G. Dimogerontas, E. Rokas, M. Papadopoulos, A. Rovlias and E. Konstandinidis
91 The expression of the Corticotropin Releasing Factor (CRF) system of neuropeptides and receptors in mouse microglia cells
E. Polakis, M. Lambropoulou, C. Charsou, C. Cheimonidou, K. Chalkiadaki and E. Chatzaki
92 Dopaminergic modifications following WIN 55,212-2 administration in the conditioned place preference paradigm
A. Polissidis, O. Chouliara, A. Galanopoulos, E.Tzavara, M. Marselos, Z. Papadopoulou-Daifoti and K. Antoniou
93 Evidence-based evaluation of emergency care treatment algorithms: 15 dominant myths
Ch. Pourzitaki, Th. Tzellos, Ch. Sardeli, G. Papazisis, E. Amaniti and D. Kouvelas
94 Combined treatment of aspartyl protease inhibitor and Nmda antagonist in Pc12 cells after glutamate excitotoxicity
C. Pourzitaki, G. Kanellos, I. Klagas and A. Kritis
95 Pregabalin combined with epidural analgesia in chronic cancer pain patients
C. Pourzitaki, H. Logotheti, C. Sardeli, G. Papazisis, P. Arampatzis and D. Kouvelas
96 Pharmacologic characteristics of the rabbit lower esophageal sphincter
Th.A. Psarra, Th.Thijs, A. Diez-Fraile, I. Depoortere, G.C. Batzias, Th.L. Peeters and M. Koutsoviti-Papadopoulou
97 Frequencies of eNOS gene polymorphisms -786T>C and 894G>T in the Greek population
G. Ragia, A. Tavridou, K. Arvanitidis, E. Nikolaidis, G. Bougioukas and V.G. Manolopoulos
98 Long-term consequences of early maternal deprivation in behavioral and neurobiological responses of adult rat
G. Rentesi, K. Antoniou, M. Marselos, M.Syrrou and M. Konstandi
99 Cell toxicity and fluorescence spectroscopy studies of carboxyl, amine and hydroxyl terminated dendrimers
A. Rucinska, K. Gardikis, , M. Ionov, M. Jokiel, T. Felekis, B.R. Steele, C.G. Screttas, C. Demetzos, M. Micha-Screttas, M. Bryszewska and T. Gabryelak
100 Deciding on the best treatment strategy for recurrent febrile seizures: an evidence-based medicine approach
Ch. Sardeli, Th. Tzellos, E. Amaniti, G. Papazisis, K. Karakoulas, Ch. Pourzitaki and D. Kouvelas
101 Efficacy of amlodipine in older hypertensive patients (>55 years) not controlled with inhibitors of the renin-angiotensin system or beta blockers
P. Semertzidis, S. Douma, K. Petidis, A. Triantafyllou, E. Galiagousi, P. Papaefthimiou, N. Papadopoulos, N. Kartali, A. Pyrpasopoulou, M. Doumas and C. Zamboulis
102 Effects of statins on key biochemical indexes of patients with acute ischemic cerebrovascular stroke
A. Sianni, A. Ganotopoulou, K. Kosma, K. Liatsos, N. Karagianni, E. Laskos and D. Vasilopoulos
103 The role of oxidative and nitrosative stress mechanisms in symptomatic carotid disease 
F. Sigala, A. Papalambros, K. Filis, S. Markantonis, M. Demopoulou, P. Sigalas, A. Kotsinas, A. Niforou, B. Gorgoulis and I. Andreadou
104 Effect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-Aspartate and [3H]-GABA from rat retina and hippocampus
V. Sourlas, V. Athanasiou and A. Vasilaki
105 Serum pseudocholinesterase levels after chronic exposure to fenthion and correlation with morbidity: cancer, liver diseases, respiratory and neurological diseases
H. Souki, G. Vrioni, M. Katramadou, D. G. Hela and H. Carageorgiou
106 Effect of Leguminosae family plant extracts and polyphenolic fractions on topoisomerase I-induced nicking of DNA
C. Spanou, N. Aligiannis, A.L. Skaltsounis and D. Kouretas
107 Effects of sibutramine treatment on food intake, serum lipoproteins and TNF-α levels in rats fed standard laboratory or three isocaloric diets
Th. Stroubini, A. Perelas, Ch. Liapi, D. Perrea, I. Dontas, M. Trapali and P. Galanopoulou
108 The implementation of British hypertension society guidelines results in improved blood pressure control in young hypertensives
A. Triantafyllou, S. Douma, K. Petidis, P. Semertzidis, E. Galiagousi, P. Papaefthimiou, N. Papadopoulos, N. Kartali, A. Pyrpasopoulou, M. Doumas and C. Zamboulis
109 The introduction of the use of stimulants for attention deficit and hyperactivity in children (and adolescents)
B. Tsakmaki and G. Papadopoulos
110 Statistical data collected during urine collection for doping control at the Athens 2004 Olympic Games and recommendations to improve the urine collection process
Ath. Tsiokanos, Ath. Jamurtas, P. Schamasch, P. Papalexis and Chr. Tsitsimpikou
111 Nitrous oxide for conscious sedation in pediatric dentistry
E. Tsirella and M. Mironidou-Tzouveleki
112 Side effects of agents used in local anaesthesia
E. Tsirella and M. Mironidou-Tzouveleki
113 Pregabalin as a new treatment strategy for neuropathic pain in spinal cord injury: an evidence based evaluation
Th. Tzellos, G. Papazisis, E. Amaniti, Ch. Sardeli, Ch.Pourzitaki, D. Tahmatzidis and D. Kouvelas
114 Differential expression of matrix metalloproteinases 2 and 9 in basal cell carcinoma, photoexposed and photoprotected skin
Th. Tzellos, I. Klagas, E. Papakonstantinou, K. Vahtsevanos, S. Triaridis, Ath. Kyrgidis, Ath. Printza, E. Zvintzou and G. Karakiulakis
115 The effect of allopurinol on protein carbonyls and swimming performance in rats
A.S. Veskoukis, M.G. Nikolaidis, A. Kyparos, D. Kokkinos, E. Varamenti and D. Kouretas
116 Cephalosporin induced haemolytic anaemia in surgical patients: systematic review
E. Yiannakopoulou
117 Property distribution in the chemical space of PPAR-γ agonists: evaluation of drug-like characteristics
C. Giaginis, A. Zira, S. Theocharis and A.Tsantili-Kakoulidou
118 Impact of obesity on cytokine secretion patterns following an oral glucose tolerance test in individuals with normal glucose tolerance
A.I. Liakou, K. Arabatzi, C.I. Liakou and M.J. Theodorakis

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